EU H2020 Project "TWIST (TOF PET With Strip SiPMs)": description, partecipants, costs and EC-fundings

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TWIST project word cloud

Explore the words cloud of the TWIST project. It provides you a very rough idea of what is the project "TWIST" about.

stage ct ssipm modules tical sensitive position tracer units injection basis successful imaging business biological precise scanners x5 occurring fundamental cellular building emitters area kev subjects scanned creation scans sub diagnostic 511 radiotracer sensitivity least enhanced background multiple diseases interaction emission manufacture forms detection close generating laboratory tests commercial functioning body images positron photomultiplier resolution reactions strip medical plan chemical silicon reduce time gamma operates point breakthrough determined clearer dosage powerful diagnosing longer lower erc image detector tomography molecular pet investigation create advantage move biomarkers twist crystals possibilities alter mounted active technique subject radio tool substantially

Project "TWIST" data sheet

The following table provides information about the project.

Coordinator	EUROPEAN ORGANIZATION FOR NUCLEAR RESEARCH Organization address address: ESPLANADE DES PARTICULES 1 PARCELLE 11482 DE MEYRIN BATIMENT CADASTRAL 1046 city: GENEVA 23 postcode: 1211 website: www.cern.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Switzerland [CH]
Total cost	150˙000 €
EC max contribution	150˙000 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2017-PoC
Funding Scheme	ERC-POC
Starting year	2018
Duration (year-month-day)	from 2018-01-01 to 2019-06-30

#	participants	country	role	EC contrib. [€]
1	EUROPEAN ORGANIZATION FOR NUCLEAR RESEARCH	CH (GENEVA 23)	coordinator	150˙000.00

EUROPEAN ORGANIZATION FOR NUCLEAR RESEARCH

CH (GENEVA 23)

coordinator

150˙000.00

Project objective

TWIST will build detector modules for PET scanners that offer high sensitivity together with precise position and time resolution. TWIST will deliver high-resolution PET images with low background using a lower dosage of radio-tracer. The breakthrough is obtained due to the successful development of the new Strip Silicon PhotoMultiplier (SSiPM) within the ERC TICAL project. PET (Positron Emission Tomography) scanners create images of the distribution of positron emitters in the body of subjects under investigation. PET scans have a fundamental advantage over other forms of medical imaging, such as CT scans; since they are sensitive to the functioning of biological processes. Biomarkers are involved in chemical reactions active in molecular pathways of interest for diagnosing diseases; the image will alter according to molecular changes occurring within the area of interest. Since the imaging technique operates at the sub-cellular and molecular level of the body, it is known as molecular imaging. Although PET imaging is a very powerful diagnostic tool, an injection of a radiotracer is required. The precise time resolution of the TWIST modules with substantially reduce the background generating clearer images. The image resolution will be further enhanced due to the determination of the 511 keV gamma interaction point (including the depth of interaction). Since the depth of interaction is well determined, longer crystals can be used and the detection modules can be mounted close to the subject being scanned. This results in higher resolution images with a significant reduction (at least x5) use of radio tracer. For all developments, it is important to move from tests in the laboratory to building a system of multiple units, because this is the stage that these new developments become useful and open up commercial possibilities. The creation of a business plan to manufacture modules on a commercial basis is integrated within this proposal.

Publications

List of publications.
year	authors and title	journal	last update
2019	K. Doroud, Z. Liu, M.C.S. Williams A new geometry of scintillating crystals with strip SiPMs: a PET detector with precise position and time determination published pages: P01016-P01016, ISSN: 1748-0221, DOI: 10.1088/1748-0221/14/01/p01016	Journal of Instrumentation 14/01	2020-02-13

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