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TWIST

TOF PET With Strip SiPMs

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 TWIST project word cloud

Explore the words cloud of the TWIST project. It provides you a very rough idea of what is the project "TWIST" about.

silicon    molecular    close    commercial    plan    detection    x5    kev    occurring    tomography    reactions    mounted    point    emitters    determined    multiple    functioning    position    scanners    stage    pet    sensitive    chemical    creation    substantially    strip    area    breakthrough    sub    gamma    body    move    least    fundamental    ct    longer    reduce    radiotracer    scanned    positron    radio    tests    interaction    basis    investigation    medical    precise    tracer    manufacture    subject    imaging    511    resolution    diagnostic    image    biomarkers    photomultiplier    enhanced    successful    business    alter    scans    clearer    erc    subjects    images    active    diagnosing    operates    technique    crystals    diseases    powerful    sensitivity    tical    lower    modules    dosage    biological    time    tool    create    possibilities    injection    laboratory    ssipm    detector    generating    building    units    cellular    emission    advantage    forms    background    twist   

Project "TWIST" data sheet

The following table provides information about the project.

Coordinator
EUROPEAN ORGANIZATION FOR NUCLEAR RESEARCH 

Organization address
address: ESPLANADE DES PARTICULES 1 PARCELLE 11482 DE MEYRIN BATIMENT CADASTRAL 1046
city: GENEVA 23
postcode: 1211
website: www.cern.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 150˙000 €
 EC max contribution 150˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-PoC
 Funding Scheme ERC-POC
 Starting year 2018
 Duration (year-month-day) from 2018-01-01   to  2019-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    EUROPEAN ORGANIZATION FOR NUCLEAR RESEARCH CH (GENEVA 23) coordinator 150˙000.00

Map

 Project objective

TWIST will build detector modules for PET scanners that offer high sensitivity together with precise position and time resolution. TWIST will deliver high-resolution PET images with low background using a lower dosage of radio-tracer. The breakthrough is obtained due to the successful development of the new Strip Silicon PhotoMultiplier (SSiPM) within the ERC TICAL project. PET (Positron Emission Tomography) scanners create images of the distribution of positron emitters in the body of subjects under investigation. PET scans have a fundamental advantage over other forms of medical imaging, such as CT scans; since they are sensitive to the functioning of biological processes. Biomarkers are involved in chemical reactions active in molecular pathways of interest for diagnosing diseases; the image will alter according to molecular changes occurring within the area of interest. Since the imaging technique operates at the sub-cellular and molecular level of the body, it is known as molecular imaging. Although PET imaging is a very powerful diagnostic tool, an injection of a radiotracer is required. The precise time resolution of the TWIST modules with substantially reduce the background generating clearer images. The image resolution will be further enhanced due to the determination of the 511 keV gamma interaction point (including the depth of interaction). Since the depth of interaction is well determined, longer crystals can be used and the detection modules can be mounted close to the subject being scanned. This results in higher resolution images with a significant reduction (at least x5) use of radio tracer. For all developments, it is important to move from tests in the laboratory to building a system of multiple units, because this is the stage that these new developments become useful and open up commercial possibilities. The creation of a business plan to manufacture modules on a commercial basis is integrated within this proposal.

 Publications

year authors and title journal last update
List of publications.
2019 K. Doroud, Z. Liu, M.C.S. Williams
A new geometry of scintillating crystals with strip SiPMs: a PET detector with precise position and time determination
published pages: P01016-P01016, ISSN: 1748-0221, DOI: 10.1088/1748-0221/14/01/p01016
Journal of Instrumentation 14/01 2020-02-13

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The information about "TWIST" are provided by the European Opendata Portal: CORDIS opendata.

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