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TWIST

TOF PET With Strip SiPMs

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 TWIST project word cloud

Explore the words cloud of the TWIST project. It provides you a very rough idea of what is the project "TWIST" about.

functioning    move    subjects    chemical    advantage    tracer    generating    building    fundamental    determined    occurring    ssipm    successful    radiotracer    crystals    reduce    operates    interaction    scans    body    possibilities    medical    mounted    tests    area    tical    511    erc    imaging    biomarkers    reactions    biological    x5    subject    background    modules    cellular    scanned    images    create    least    injection    close    laboratory    gamma    ct    photomultiplier    sensitive    molecular    sub    diagnostic    position    twist    multiple    resolution    diagnosing    technique    pet    substantially    tomography    breakthrough    strip    stage    alter    kev    emission    commercial    active    diseases    precise    investigation    enhanced    basis    dosage    clearer    units    creation    point    sensitivity    silicon    image    time    detection    detector    emitters    powerful    forms    positron    lower    tool    radio    longer    manufacture    business    scanners    plan   

Project "TWIST" data sheet

The following table provides information about the project.

Coordinator
EUROPEAN ORGANIZATION FOR NUCLEAR RESEARCH 

Organization address
address: ESPLANADE DES PARTICULES 1 PARCELLE 11482 DE MEYRIN BATIMENT CADASTRAL 1046
city: GENEVA 23
postcode: 1211
website: www.cern.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 150˙000 €
 EC max contribution 150˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-PoC
 Funding Scheme ERC-POC
 Starting year 2018
 Duration (year-month-day) from 2018-01-01   to  2019-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    EUROPEAN ORGANIZATION FOR NUCLEAR RESEARCH CH (GENEVA 23) coordinator 150˙000.00

Map

 Project objective

TWIST will build detector modules for PET scanners that offer high sensitivity together with precise position and time resolution. TWIST will deliver high-resolution PET images with low background using a lower dosage of radio-tracer. The breakthrough is obtained due to the successful development of the new Strip Silicon PhotoMultiplier (SSiPM) within the ERC TICAL project. PET (Positron Emission Tomography) scanners create images of the distribution of positron emitters in the body of subjects under investigation. PET scans have a fundamental advantage over other forms of medical imaging, such as CT scans; since they are sensitive to the functioning of biological processes. Biomarkers are involved in chemical reactions active in molecular pathways of interest for diagnosing diseases; the image will alter according to molecular changes occurring within the area of interest. Since the imaging technique operates at the sub-cellular and molecular level of the body, it is known as molecular imaging. Although PET imaging is a very powerful diagnostic tool, an injection of a radiotracer is required. The precise time resolution of the TWIST modules with substantially reduce the background generating clearer images. The image resolution will be further enhanced due to the determination of the 511 keV gamma interaction point (including the depth of interaction). Since the depth of interaction is well determined, longer crystals can be used and the detection modules can be mounted close to the subject being scanned. This results in higher resolution images with a significant reduction (at least x5) use of radio tracer. For all developments, it is important to move from tests in the laboratory to building a system of multiple units, because this is the stage that these new developments become useful and open up commercial possibilities. The creation of a business plan to manufacture modules on a commercial basis is integrated within this proposal.

 Publications

year authors and title journal last update
List of publications.
2019 K. Doroud, Z. Liu, M.C.S. Williams
A new geometry of scintillating crystals with strip SiPMs: a PET detector with precise position and time determination
published pages: P01016-P01016, ISSN: 1748-0221, DOI: 10.1088/1748-0221/14/01/p01016
Journal of Instrumentation 14/01 2020-02-13

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