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TWIST

TOF PET With Strip SiPMs

Total Cost €

0

EC-Contrib. €

0

Partnership

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 TWIST project word cloud

Explore the words cloud of the TWIST project. It provides you a very rough idea of what is the project "TWIST" about.

plan    generating    time    detection    tomography    longer    body    substantially    crystals    imaging    twist    fundamental    create    positron    kev    diagnosing    radiotracer    images    move    ssipm    tracer    clearer    emission    diagnostic    enhanced    precise    image    scanned    sub    emitters    breakthrough    resolution    injection    scanners    sensitivity    functioning    least    possibilities    alter    gamma    pet    detector    scans    interaction    stage    creation    cellular    technique    dosage    biological    laboratory    sensitive    erc    background    tests    biomarkers    silicon    511    forms    medical    chemical    modules    x5    point    photomultiplier    powerful    reduce    advantage    subject    units    radio    multiple    commercial    basis    active    area    determined    mounted    investigation    operates    subjects    business    position    tool    close    lower    successful    molecular    strip    reactions    manufacture    building    ct    occurring    tical    diseases   

Project "TWIST" data sheet

The following table provides information about the project.

Coordinator
EUROPEAN ORGANIZATION FOR NUCLEAR RESEARCH 

Organization address
address: ESPLANADE DES PARTICULES 1 PARCELLE 11482 DE MEYRIN BATIMENT CADASTRAL 1046
city: GENEVA 23
postcode: 1211
website: www.cern.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 150˙000 €
 EC max contribution 150˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-PoC
 Funding Scheme ERC-POC
 Starting year 2018
 Duration (year-month-day) from 2018-01-01   to  2019-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    EUROPEAN ORGANIZATION FOR NUCLEAR RESEARCH CH (GENEVA 23) coordinator 150˙000.00

Map

 Project objective

TWIST will build detector modules for PET scanners that offer high sensitivity together with precise position and time resolution. TWIST will deliver high-resolution PET images with low background using a lower dosage of radio-tracer. The breakthrough is obtained due to the successful development of the new Strip Silicon PhotoMultiplier (SSiPM) within the ERC TICAL project. PET (Positron Emission Tomography) scanners create images of the distribution of positron emitters in the body of subjects under investigation. PET scans have a fundamental advantage over other forms of medical imaging, such as CT scans; since they are sensitive to the functioning of biological processes. Biomarkers are involved in chemical reactions active in molecular pathways of interest for diagnosing diseases; the image will alter according to molecular changes occurring within the area of interest. Since the imaging technique operates at the sub-cellular and molecular level of the body, it is known as molecular imaging. Although PET imaging is a very powerful diagnostic tool, an injection of a radiotracer is required. The precise time resolution of the TWIST modules with substantially reduce the background generating clearer images. The image resolution will be further enhanced due to the determination of the 511 keV gamma interaction point (including the depth of interaction). Since the depth of interaction is well determined, longer crystals can be used and the detection modules can be mounted close to the subject being scanned. This results in higher resolution images with a significant reduction (at least x5) use of radio tracer. For all developments, it is important to move from tests in the laboratory to building a system of multiple units, because this is the stage that these new developments become useful and open up commercial possibilities. The creation of a business plan to manufacture modules on a commercial basis is integrated within this proposal.

 Publications

year authors and title journal last update
List of publications.
2019 K. Doroud, Z. Liu, M.C.S. Williams
A new geometry of scintillating crystals with strip SiPMs: a PET detector with precise position and time determination
published pages: P01016-P01016, ISSN: 1748-0221, DOI: 10.1088/1748-0221/14/01/p01016
Journal of Instrumentation 14/01 2020-02-13

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