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Nanomaterials in Oncology: Exploiting the Intrinsic Cancer-Specific Toxicity of Nanoparticles.

Total Cost €


EC-Contrib. €






 NANONC project word cloud

Explore the words cloud of the NANONC project. It provides you a very rough idea of what is the project "NANONC" about.

certain    optical    specificity    strategy    sizes    morbidity    selectively    homing    clinical    clinics    loaded    cells    mechanisms    first    premature    chemically    efficacy    primarily    formulations    treat    destroy    vehicles    undergoing    physical    frequent    efficient    trials    induce    gene    intrinsic    nms    date    difficult    strategies    explore    prone    types    limiting    therapeutic    multidrug    society    biological    selective    ag    coatings    doped    cancer    obtain    toxicity    nanomaterials    rate    full    imaging    hereby    zno    dose    suffer    monitored    impeding    re    tumor    resistant    cuo    cell    shown    fe    mediators    degradation    cytoplasmic    hyperthermia    expressing    limited    loading    carriers    home    overcome    rising    destroyed    tumors    nm    cancers    site    cytoplasm    tool    primary    metastases    release    enhanced    selectivity    suicide    treatment    metal    once    drug    kinetics    lack    anticancer    anti   

Project "NANONC" data sheet

The following table provides information about the project.


Organization address
address: OUDE MARKT 13
city: LEUVEN
postcode: 3000

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 1˙947˙519 €
 EC max contribution 1˙947˙519 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-01-01   to  2022-12-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KATHOLIEKE UNIVERSITEIT LEUVEN BE (LEUVEN) coordinator 1˙947˙519.00


 Project objective

In our current society, therapeutic strategies against cancer suffer from dose-limiting toxicity, lack of specificity and high morbidity. To overcome this, the use of nanomaterials (NMs) is rising, where several NM formulations are undergoing clinical trials or are used in clinics where the NMs are used as drug delivery vehicles or as mediators in physical anticancer methods (e.g. hyperthermia), where to date, the success rate is limited due to low tumor targeting efficacy, lack of specificity and frequent re-use of classical toxicity mechanisms.

To overcome these issues, this research program aims to exploit the intrinsic toxicity of certain types of metal-based, degradation-prone NMs (Fe-doped ZnO, Fe-doped CuO and Ag of different sizes and coatings) towards only cancer cells as a novel and generic anti-cancer tool with 1) improved efficacy against difficult to treat cancers such as multidrug-resistant cancer cells, 2) enhanced specificity and selectivity of the treatment by the intrinsic cancer cell-specific toxicity of NMs towards cancer cells. To overcome the issues related to selective delivery of the NMs, tumor-homing cells will be used that have been shown to efficiently home to primary tumors and their metastases. In practice, the NMs used show distinct degradation kinetics that primarily induce cancer-selective toxicity. To obtain efficient tumor targeting, suicide gene-expressing tumor-homing cells will be loaded with the NMs in their cytoplasm, hereby impeding premature NM degradation. The tumor homing efficacy of these cells will be monitored via optical imaging and once at the target site these cells will be chemically destroyed using the suicide gene strategy. This will release the NMs into the tumor site, where they can selectively destroy the cancer cells. This research program will be the first to explore the full potential of cancer-specific toxicity of NMs and the use of cytoplasmic loading of cells as biological carriers for efficient delivery.

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The information about "NANONC" are provided by the European Opendata Portal: CORDIS opendata.

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