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NANONC SIGNED

Nanomaterials in Oncology: Exploiting the Intrinsic Cancer-Specific Toxicity of Nanoparticles.

Total Cost €

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EC-Contrib. €

0

Partnership

0

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 NANONC project word cloud

Explore the words cloud of the NANONC project. It provides you a very rough idea of what is the project "NANONC" about.

ag    metal    selectively    certain    selective    tumors    destroy    tool    cell    tumor    cytoplasm    imaging    suicide    strategy    nanomaterials    cytoplasmic    doped    intrinsic    home    efficacy    kinetics    multidrug    shown    primarily    strategies    obtain    rising    difficult    loading    hereby    enhanced    degradation    selectivity    full    anti    formulations    morbidity    cancer    efficient    clinical    gene    metastases    cells    release    society    therapeutic    treat    resistant    biological    suffer    vehicles    cuo    mechanisms    optical    once    cancers    physical    hyperthermia    premature    mediators    undergoing    lack    re    drug    overcome    carriers    specificity    limiting    treatment    nm    coatings    site    homing    loaded    chemically    sizes    dose    limited    rate    explore    monitored    nms    induce    zno    expressing    date    impeding    fe    primary    destroyed    frequent    types    first    trials    toxicity    anticancer    clinics    prone   

Project "NANONC" data sheet

The following table provides information about the project.

Coordinator
KATHOLIEKE UNIVERSITEIT LEUVEN 

Organization address
address: OUDE MARKT 13
city: LEUVEN
postcode: 3000
website: www.kuleuven.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 1˙947˙519 €
 EC max contribution 1˙947˙519 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-01-01   to  2022-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KATHOLIEKE UNIVERSITEIT LEUVEN BE (LEUVEN) coordinator 1˙947˙519.00

Map

 Project objective

In our current society, therapeutic strategies against cancer suffer from dose-limiting toxicity, lack of specificity and high morbidity. To overcome this, the use of nanomaterials (NMs) is rising, where several NM formulations are undergoing clinical trials or are used in clinics where the NMs are used as drug delivery vehicles or as mediators in physical anticancer methods (e.g. hyperthermia), where to date, the success rate is limited due to low tumor targeting efficacy, lack of specificity and frequent re-use of classical toxicity mechanisms.

To overcome these issues, this research program aims to exploit the intrinsic toxicity of certain types of metal-based, degradation-prone NMs (Fe-doped ZnO, Fe-doped CuO and Ag of different sizes and coatings) towards only cancer cells as a novel and generic anti-cancer tool with 1) improved efficacy against difficult to treat cancers such as multidrug-resistant cancer cells, 2) enhanced specificity and selectivity of the treatment by the intrinsic cancer cell-specific toxicity of NMs towards cancer cells. To overcome the issues related to selective delivery of the NMs, tumor-homing cells will be used that have been shown to efficiently home to primary tumors and their metastases. In practice, the NMs used show distinct degradation kinetics that primarily induce cancer-selective toxicity. To obtain efficient tumor targeting, suicide gene-expressing tumor-homing cells will be loaded with the NMs in their cytoplasm, hereby impeding premature NM degradation. The tumor homing efficacy of these cells will be monitored via optical imaging and once at the target site these cells will be chemically destroyed using the suicide gene strategy. This will release the NMs into the tumor site, where they can selectively destroy the cancer cells. This research program will be the first to explore the full potential of cancer-specific toxicity of NMs and the use of cytoplasmic loading of cells as biological carriers for efficient delivery.

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The information about "NANONC" are provided by the European Opendata Portal: CORDIS opendata.

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