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EnBioN SIGNED

Engineering the Biointerface of Nanowires to Direct Stem Cell Differentiation

Total Cost €

EC-Contrib. €

Partnership

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EnBioN project word cloud

Explore the words cloud of the EnBioN project. It provides you a very rough idea of what is the project "EnBioN" about.

evident platform biological stem efficient combining environment mechanisms tissue guide lengthscale timeliness enbion rational nanowire directing localize mechanosensory nanostructures multiple vector manipulation undeveloped tools therapy ing highlighted medicine localized epigenetic free debated elusive ratio engineer integrating arrays organelles broad engineering vertical stimulation despite regeneration technologies dynamic differentiation regenerative permeability arising cell induce stimuli nanowires unexplored microenvironment fate cells resolution niche cellular ensue guidelines highlights signalling critical unknown principles interface intracellular biointerface relies direct governing nanomaterials reprogramming interaction gene transfection degree regulatory strategies membrane sensing largely integrate thanks

Project "EnBioN" data sheet

The following table provides information about the project.

Coordinator	KING'S COLLEGE LONDON Organization address address: STRAND city: LONDON postcode: WC2R 2LS website: www.kcl.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Total cost	1˙495˙430 €
EC max contribution	1˙495˙430 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2017-STG
Funding Scheme	ERC-STG
Starting year	2018
Duration (year-month-day)	from 2018-02-01 to 2023-01-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	KING'S COLLEGE LONDON KING'S COLLEGE LONDON Organization address address: STRAND city: LONDON postcode: WC2R 2LS website: www.kcl.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	coordinator	1˙495˙430.00

Map

Project objective

ENBION will engineer a platform to direct the differentiation of stem cells by developing principles for the rational design of the biointerface of nanowires. It is increasingly evident that efficient tissue regeneration can only ensue from combining the regenerative potential of stem cells with regulatory stimuli from gene therapy and niche engineering. Yet, despite significant advances towards integrating these technologies, the necessary degree of control over cell fate remains elusive. Vertical arrays of high aspect ratio nanostructures (nanowires) are rapidly emerging as promising tools to direct cell fate. Thanks to their unique biointerface, nanowires enable gene delivery, intracellular sensing, and direct stimulation of signalling pathways, achieving dynamic manipulation of cells and their environment. This broad manipulation potential highlights the importance and timeliness of engineering nanowires for regenerative medicine. However, developing a nanowire platform to direct stem cell fate requires design principles based on the largely unknown biological processes governing their interaction with cells. Enabling localized, vector-free gene therapy through efficient transfection relies on understanding the still debated mechanisms by which nanowires induce membrane permeability. Directing cell reprogramming requires understanding the largely unexplored mechanosensory processes and the resulting epigenetic effects arising from the direct interaction of nanowires with multiple organelles within the cell. Engineering the cell microenvironment requires yet undeveloped strategies to localize signalling and transfection with a resolution comparable to the lengthscale of cells. ENBION will develop this critical knowledge and integrate it into guidelines for dynamic manipulation of cells. Beyond the nanowire platform, the principles highlighted by this unique interface can guide the development of nanomaterials with improved control over cellular processes.

Publications

List of publications.
year	authors and title	journal	last update
2019	Valentina Onesto, William B. Barrell, Mary Okesola, Francesco Amato, Francesco Gentile, Karen J. Liu, Ciro Chiappini A quantitative approach for determining the role of geometrical constraints when shaping mesenchymal condensations published pages: , ISSN: 1387-2176, DOI: 10.1007/s10544-019-0390-0	Biomedical Microdevices 21/2	2019-10-01
2019	Sebastiaan Zijl, Aliaksei S. Vasilevich, Priyalakshmi Viswanathan, Ayelen Luna Helling, Nick R.M. Beijer, Gernot Walko, Ciro Chiappini, Jan de Boer, Fiona M. Watt Micro-scaled topographies direct differentiation of human epidermal stem cells published pages: 133-145, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2018.12.003	Acta Biomaterialia 84	2019-10-01
2019	Sahana Gopal, Ciro Chiappini, James P. K. Armstrong, Qu Chen, Andrea Serio, Chia-Chen Hsu, Christoph Meinert, Travis J. Klein, Dietmar W. Hutmacher, Stephen Rothery, Molly M. Stevens Immunogold FIB-SEM: Combining Volumetric Ultrastructure Visualization with 3D Biomolecular Analysis to Dissect Cell-Environment Interactions published pages: 1900488, ISSN: 0935-9648, DOI: 10.1002/adma.201900488	Advanced Materials 31/32	2019-10-01
2019	Catherine S. Hansel, Spencer W. Crowder, Samuel Cooper, Sahana Gopal, Maria JoÃ£o Pardelha da Cruz, Leonardo de Oliveira Martins, Debora Keller, Stephen Rothery, Michele Becce, Anthony E. G. Cass, Chris Bakal, Ciro Chiappini, Molly M. Stevens Nanoneedle-Mediated Stimulation of Cell Mechanotransduction Machinery published pages: 2913-2926, ISSN: 1936-0851, DOI: 10.1021/acsnano.8b06998	ACS Nano 13/3	2019-10-01
2019	Sahana Gopal, Ciro Chiappini, Jelle Penders, Vincent Leonardo, Hyejeong Seong, Stephen Rothery, Yuri Korchev, Andrew Shevchuk, Molly M. Stevens Porous Silicon Nanoneedles Modulate Endocytosis to Deliver Biological Payloads published pages: 1806788, ISSN: 0935-9648, DOI: 10.1002/adma.201806788	Advanced Materials 31/12	2019-10-01

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The information about "ENBION" are provided by the European Opendata Portal: CORDIS opendata.

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