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EnBioN SIGNED

Engineering the Biointerface of Nanowires to Direct Stem Cell Differentiation

Total Cost €

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EC-Contrib. €

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Partnership

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 EnBioN project word cloud

Explore the words cloud of the EnBioN project. It provides you a very rough idea of what is the project "EnBioN" about.

vector    transfection    debated    despite    gene    directing    organelles    enbion    interface    biological    undeveloped    nanowire    permeability    reprogramming    technologies    differentiation    tissue    timeliness    principles    relies    medicine    integrating    therapy    free    broad    interaction    unknown    strategies    efficient    critical    stem    manipulation    largely    unexplored    ratio    sensing    evident    platform    cell    lengthscale    guide    arrays    degree    nanostructures    engineering    stimuli    guidelines    governing    engineer    elusive    cellular    regeneration    integrate    multiple    tools    vertical    ing    localized    regenerative    mechanosensory    resolution    highlighted    arising    stimulation    dynamic    epigenetic    thanks    fate    direct    localize    environment    biointerface    regulatory    intracellular    rational    signalling    nanomaterials    niche    induce    cells    combining    nanowires    highlights    microenvironment    mechanisms    membrane    ensue   

Project "EnBioN" data sheet

The following table provides information about the project.

Coordinator
KING'S COLLEGE LONDON 

Organization address
address: STRAND
city: LONDON
postcode: WC2R 2LS
website: www.kcl.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 1˙495˙430 €
 EC max contribution 1˙495˙430 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-02-01   to  2023-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KING'S COLLEGE LONDON UK (LONDON) coordinator 1˙495˙430.00

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 Project objective

ENBION will engineer a platform to direct the differentiation of stem cells by developing principles for the rational design of the biointerface of nanowires. It is increasingly evident that efficient tissue regeneration can only ensue from combining the regenerative potential of stem cells with regulatory stimuli from gene therapy and niche engineering. Yet, despite significant advances towards integrating these technologies, the necessary degree of control over cell fate remains elusive. Vertical arrays of high aspect ratio nanostructures (nanowires) are rapidly emerging as promising tools to direct cell fate. Thanks to their unique biointerface, nanowires enable gene delivery, intracellular sensing, and direct stimulation of signalling pathways, achieving dynamic manipulation of cells and their environment. This broad manipulation potential highlights the importance and timeliness of engineering nanowires for regenerative medicine. However, developing a nanowire platform to direct stem cell fate requires design principles based on the largely unknown biological processes governing their interaction with cells. Enabling localized, vector-free gene therapy through efficient transfection relies on understanding the still debated mechanisms by which nanowires induce membrane permeability. Directing cell reprogramming requires understanding the largely unexplored mechanosensory processes and the resulting epigenetic effects arising from the direct interaction of nanowires with multiple organelles within the cell. Engineering the cell microenvironment requires yet undeveloped strategies to localize signalling and transfection with a resolution comparable to the lengthscale of cells. ENBION will develop this critical knowledge and integrate it into guidelines for dynamic manipulation of cells. Beyond the nanowire platform, the principles highlighted by this unique interface can guide the development of nanomaterials with improved control over cellular processes.

 Publications

year authors and title journal last update
List of publications.
2019 Valentina Onesto, William B. Barrell, Mary Okesola, Francesco Amato, Francesco Gentile, Karen J. Liu, Ciro Chiappini
A quantitative approach for determining the role of geometrical constraints when shaping mesenchymal condensations
published pages: , ISSN: 1387-2176, DOI: 10.1007/s10544-019-0390-0
Biomedical Microdevices 21/2 2019-10-01
2019 Sebastiaan Zijl, Aliaksei S. Vasilevich, Priyalakshmi Viswanathan, Ayelen Luna Helling, Nick R.M. Beijer, Gernot Walko, Ciro Chiappini, Jan de Boer, Fiona M. Watt
Micro-scaled topographies direct differentiation of human epidermal stem cells
published pages: 133-145, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2018.12.003
Acta Biomaterialia 84 2019-10-01
2019 Sahana Gopal, Ciro Chiappini, James P. K. Armstrong, Qu Chen, Andrea Serio, Chia-Chen Hsu, Christoph Meinert, Travis J. Klein, Dietmar W. Hutmacher, Stephen Rothery, Molly M. Stevens
Immunogold FIB-SEM: Combining Volumetric Ultrastructure Visualization with 3D Biomolecular Analysis to Dissect Cell-Environment Interactions
published pages: 1900488, ISSN: 0935-9648, DOI: 10.1002/adma.201900488
Advanced Materials 31/32 2019-10-01
2019 Catherine S. Hansel, Spencer W. Crowder, Samuel Cooper, Sahana Gopal, Maria João Pardelha da Cruz, Leonardo de Oliveira Martins, Debora Keller, Stephen Rothery, Michele Becce, Anthony E. G. Cass, Chris Bakal, Ciro Chiappini, Molly M. Stevens
Nanoneedle-Mediated Stimulation of Cell Mechanotransduction Machinery
published pages: 2913-2926, ISSN: 1936-0851, DOI: 10.1021/acsnano.8b06998
ACS Nano 13/3 2019-10-01
2019 Sahana Gopal, Ciro Chiappini, Jelle Penders, Vincent Leonardo, Hyejeong Seong, Stephen Rothery, Yuri Korchev, Andrew Shevchuk, Molly M. Stevens
Porous Silicon Nanoneedles Modulate Endocytosis to Deliver Biological Payloads
published pages: 1806788, ISSN: 0935-9648, DOI: 10.1002/adma.201806788
Advanced Materials 31/12 2019-10-01

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