EnBioN SIGNED
Engineering the Biointerface of Nanowires to Direct Stem Cell Differentiation
Total Cost €
0EC-Contrib. €
0Partnership
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0EnBioN project word cloud
Explore the words cloud of the EnBioN project. It provides you a very rough idea of what is the project "EnBioN" about.
Project "EnBioN" data sheet
The following table provides information about the project.
| Coordinator |
KING'S COLLEGE LONDON
Organization address contact info |
| Coordinator Country | United Kingdom [UK] |
| Total cost | 1˙495˙430 € |
| EC max contribution | 1˙495˙430 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2017-STG |
| Funding Scheme | ERC-STG |
| Starting year | 2018 |
| Duration (year-month-day) | from 2018-02-01 to 2023-01-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | KING'S COLLEGE LONDON | UK (LONDON) | coordinator | 1˙495˙430.00 |
Map
Project objective
ENBION will engineer a platform to direct the differentiation of stem cells by developing principles for the rational design of the biointerface of nanowires. It is increasingly evident that efficient tissue regeneration can only ensue from combining the regenerative potential of stem cells with regulatory stimuli from gene therapy and niche engineering. Yet, despite significant advances towards integrating these technologies, the necessary degree of control over cell fate remains elusive. Vertical arrays of high aspect ratio nanostructures (nanowires) are rapidly emerging as promising tools to direct cell fate. Thanks to their unique biointerface, nanowires enable gene delivery, intracellular sensing, and direct stimulation of signalling pathways, achieving dynamic manipulation of cells and their environment. This broad manipulation potential highlights the importance and timeliness of engineering nanowires for regenerative medicine. However, developing a nanowire platform to direct stem cell fate requires design principles based on the largely unknown biological processes governing their interaction with cells. Enabling localized, vector-free gene therapy through efficient transfection relies on understanding the still debated mechanisms by which nanowires induce membrane permeability. Directing cell reprogramming requires understanding the largely unexplored mechanosensory processes and the resulting epigenetic effects arising from the direct interaction of nanowires with multiple organelles within the cell. Engineering the cell microenvironment requires yet undeveloped strategies to localize signalling and transfection with a resolution comparable to the lengthscale of cells. ENBION will develop this critical knowledge and integrate it into guidelines for dynamic manipulation of cells. Beyond the nanowire platform, the principles highlighted by this unique interface can guide the development of nanomaterials with improved control over cellular processes.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2019 |
Valentina Onesto, William B. Barrell, Mary Okesola, Francesco Amato, Francesco Gentile, Karen J. Liu, Ciro Chiappini A quantitative approach for determining the role of geometrical constraints when shaping mesenchymal condensations published pages: , ISSN: 1387-2176, DOI: 10.1007/s10544-019-0390-0 |
Biomedical Microdevices 21/2 | 2019-10-01 |
| 2019 |
Sebastiaan Zijl, Aliaksei S. Vasilevich, Priyalakshmi Viswanathan, Ayelen Luna Helling, Nick R.M. Beijer, Gernot Walko, Ciro Chiappini, Jan de Boer, Fiona M. Watt Micro-scaled topographies direct differentiation of human epidermal stem cells published pages: 133-145, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2018.12.003 |
Acta Biomaterialia 84 | 2019-10-01 |
| 2019 |
Sahana Gopal, Ciro Chiappini, James P. K. Armstrong, Qu Chen, Andrea Serio, Chia-Chen Hsu, Christoph Meinert, Travis J. Klein, Dietmar W. Hutmacher, Stephen Rothery, Molly M. Stevens Immunogold FIB-SEM: Combining Volumetric Ultrastructure Visualization with 3D Biomolecular Analysis to Dissect Cell-Environment Interactions published pages: 1900488, ISSN: 0935-9648, DOI: 10.1002/adma.201900488 |
Advanced Materials 31/32 | 2019-10-01 |
| 2019 |
Catherine S. Hansel, Spencer W. Crowder, Samuel Cooper, Sahana Gopal, Maria João Pardelha da Cruz, Leonardo de Oliveira Martins, Debora Keller, Stephen Rothery, Michele Becce, Anthony E. G. Cass, Chris Bakal, Ciro Chiappini, Molly M. Stevens Nanoneedle-Mediated Stimulation of Cell Mechanotransduction Machinery published pages: 2913-2926, ISSN: 1936-0851, DOI: 10.1021/acsnano.8b06998 |
ACS Nano 13/3 | 2019-10-01 |
| 2019 |
Sahana Gopal, Ciro Chiappini, Jelle Penders, Vincent Leonardo, Hyejeong Seong, Stephen Rothery, Yuri Korchev, Andrew Shevchuk, Molly M. Stevens Porous Silicon Nanoneedles Modulate Endocytosis to Deliver Biological Payloads published pages: 1806788, ISSN: 0935-9648, DOI: 10.1002/adma.201806788 |
Advanced Materials 31/12 | 2019-10-01 |
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