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INSIST SIGNED

IN-Silico trials for treatment of acute Ischemic STroke

Total Cost €

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EC-Contrib. €

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Partnership

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Project "INSIST" data sheet

The following table provides information about the project.

Coordinator
ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM 

Organization address
address: MEIBERGDREEF 15
city: AMSTERDAM
postcode: 1105AZ
website: www.amc.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Project website https://www.insist-h2020.eu/
 Total cost 5˙550˙675 €
 EC max contribution 5˙250˙675 € (95%)
 Programme 1. H2020-EU.3.1.5. (Methods and data)
 Code Call H2020-SC1-2017-CNECT-2
 Funding Scheme RIA
 Starting year 2017
 Duration (year-month-day) from 2017-11-01   to  2021-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM NL (AMSTERDAM) coordinator 908˙085.00
2    UNIVERSITE DE GENEVE CH (GENEVE) participant 771˙975.00
3    ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM NL (ROTTERDAM) participant 717˙500.00
4    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD UK (OXFORD) participant 568˙125.00
5    UNIVERSITEIT VAN AMSTERDAM NL (AMSTERDAM) participant 545˙750.00
6    KATHOLIEKE UNIVERSITEIT LEUVEN BE (LEUVEN) participant 462˙500.00
7    NATIONAL UNIVERSITY OF IRELAND GALWAY IE (Galway) participant 425˙365.00
8    NEURAVI LIMITED IE (GALWAY) participant 416˙275.00
9    POLITECNICO DI MILANO IT (MILANO) participant 349˙600.00
10    INSTITUT DE RECHERCHES INTERNATIONALES SERVIER FR (SURESNES) participant 85˙500.00
11    M.V. LOMONOSOV MOSCOW STATE UNIVERSITY RU (MOSCOW) participant 0.00

Map

 Project objective

Stroke is the number one cause of disability in the Western world and the 3rd most common cause of death. Despite new treatment options with intra-arterial thrombectomy, still 2 out of 3 patients still have a poor outcome. The main goal of INSIST is to advance treatments of ischemic stroke and its introduction in clinical practice by realizing in silico clinical stroke trials in which stroke and treatment are modeled. We will generate virtual populations of stroke patients, generate and validate in silico models for intra-arterial thrombectomy, thrombosis and thrombolysis, and microvascular perfusion and neurological deterioration after stroke, and integrate the in silico models to realize an in silico clinical stroke trial. We are uniquely positioned by the availability of a large pool of clinical, imaging, histopathological, and outcome data from multiple recently finalized stroke trials, a large registry (totaling 4500 patients), and new trials that will start later this year (totaling 2500 patients). We will build a population model that takes this input to generate virtual populations of stroke patients addressing the wide variety of patient characteristics. We will build on existing and emerging in silico models to validate reusable models for stroke and stroke treatment with a strong interaction with experimenting modeling in laboratories. The in silico models and virtual populations will be combined to simulate clinical trials and validated by simulating and comparing finalized and currently running trials. The in silico models will be used to simulate clinical trials to evaluate effectiveness and safety of novel devices and medication, both for the device as well as the pharmacological industry. For the device industry, we will evaluate the optimal configuration of thrombectomy stents for reduction of thrombus fragmentation. From the perspective of the pharmacy industry, we will simulate the effect of increased TAFIa on the effectiveness of alteplase.

 Deliverables

List of deliverables.
Periodic reporting Documents, reports 2019-09-02 12:14:23
Quality Assurance Plan Documents, reports 2019-09-02 12:14:23
First report on dissemination, communication and sustainability Websites, patent fillings, videos etc. 2019-09-02 12:14:23
First report on models for thrombosis and thrombolysis and combined model describing the models and performed experiments Documents, reports 2019-09-02 12:14:23
Finite element meshes of patient specific clot and vessel geometries Documents, reports 2019-09-02 12:14:23
First version of a virtual population of stroke patients (Module I) Other 2019-09-02 12:14:23
Implementation of model of microvascular damage Documents, reports 2019-09-02 12:14:23
Initial report on dissemination, exploitation and sustainability plan Documents, reports 2019-09-02 12:14:23
Project Handbook Documents, reports 2019-09-02 12:14:23
An in silico clinical stroke trial computing environment Documents, reports 2019-09-02 12:14:23
Data Management Plan template Documents, reports 2019-09-02 12:14:23
Consortium Agreement Documents, reports 2019-09-02 12:14:23

Take a look to the deliverables list in detail:  detailed list of INSIST deliverables.

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The information about "INSIST" are provided by the European Opendata Portal: CORDIS opendata.

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