Opendata, web and dolomites
JetCell
Microfluidic bubble JET flow CELL sorter for cell therapy
Total Cost €
0EC-Contrib. €
0Partnership
0Views
0JetCell project word cloud
Explore the words cloud of the JetCell project. It provides you a very rough idea of what is the project "JetCell" about.
biosafety
flow
meanwhile
immune
precisely
affordability
models
blood
demand
micro
infused
immunomagnetic
engineered
bubbles
aerosol
isolated
activated
demonstrated
efficacy
promise
scalpel
affordable
primary
first
consequently
tissues
setup
jetcell
heater
manufacturing
erc
strategy
too
chip
array
pulse
market
free
techniques
initial
thermal
cell
body
patient
risky
human
back
sec
prototype
cells
silicon
fabricated
either
business
tumor
safe
certain
feasibility
serve
purified
throughput
direct
technique
shown
flexibility
lack
course
metal
markers
vapor
marker
modified
sorting
enrichment
speed
bubble
clinical
jet
cancer
expensive
lines
isolation
fluorescence
therapy
guaranteed
malignant
sorter
eliminate
attack
Project "JetCell" data sheet
The following table provides information about the project.
| Coordinator |
INTERUNIVERSITAIR MICRO-ELECTRONICA CENTRUM
Organization address contact info |
| Coordinator Country | Belgium [BE] |
| Total cost | 149˙379 € |
| EC max contribution | 149˙379 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2016-PoC |
| Funding Scheme | ERC-POC |
| Starting year | 2018 |
| Duration (year-month-day) | from 2018-01-01 to 2019-06-30 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | INTERUNIVERSITAIR MICRO-ELECTRONICA CENTRUM | BE (LEUVEN) | coordinator | 149˙379.00 |
Map
Project objective
'T cell based cancer therapy has been recognized as one of the most promising future cancer therapy methods. In a typical T cell therapy course, relevant T cells are isolated from the patient’s blood, modified against certain cancer markers, and infused back into the patient’s body where the engineered T cells direct the immune system to attack and finally eliminate the malignant tumor cells and tissues. Recent clinical research demonstrated that purified T cell subsets could greatly improve the therapy efficacy. However, currently available T cell enrichment techniques including fluorescence activated cell sorting and immunomagnetic isolation are either too expensive and risky, or they lack the multi-marker support. Therefore, there is a need for safe, affordable and multi-marker based T cell enrichment methods for cell therapy applications. In ERC-SCALPEL project, we developed a thermal vapor bubble jet flow technique for high speed fluorescence cell sorting. The bubble jet flow sorter was based on a precisely fabricated metal heater in a silicon chip. A short current pulse applied to this metal heater induced an array of micro vapor bubbles and consequently a jet flow for high speed aerosol-free cell sorting at 4,000 cells/sec. The bubble jet sorter has shown promise to serve the cell therapy demand: high throughput, high flexibility, guaranteed biosafety and affordability. The JetCell project aims at carrying out a feasibility study of bubble jet sorting technology for the enrichment of T cells as the first step of a typical cell manufacturing process for cancer cell therapy. With a prototype setup, the bubble jet sorter will be assessed in typical pre-clinical cell manufacturing models, from human cell lines to primary blood cells. Meanwhile, the cell therapy manufacturing market will be further analyzed and an initial business development strategy will be investigated.
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The information about "JETCELL" are provided by the European Opendata Portal: CORDIS opendata.
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