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GOTBONE TERMINATED

Novel mechanisms of site-specific regulation of bone strength for the prevention of osteoporotic fractures: a translational project

Total Cost €

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EC-Contrib. €

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Partnership

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 Outcomes and results

 GOTBONE project word cloud

Explore the words cloud of the GOTBONE project. It provides you a very rough idea of what is the project "GOTBONE" about.

translate    sustain    performed    density    population    prospective    impaired    complementary    cortical    40    microarchitecture    rheumatology    women    background    lifetime    volumetric    reducing    least    n    site    osteoporotic    2014    hip    assistant    economic    models    clinical    protein    vertebral    basis    wnt    fractures    notum    lab    serum    excellence    translational    added    genetic    mineral    cultures    collaborations    genetically    special    biomarkers    burden    trabecular    cell    biology    regulates    nature    regulator    preclinical    cohort    osteoarthritis    lipase    spectrum    determinants    drugs    mortality    fragility    modified    medicine    predicts    skills    thickness    representing    morphogenetic    dependent    prevention    regulation    bone    fellowship    therapies    murine    career    remaining    professor    bmd    huge    antagonist    risk    academic    human    15    epidemiological    fracture    health    locus    supervisor    interaction    wnt16    regulating    men    mechanisms    grem2    3010    osteoporosis   

Project "GOTBONE" data sheet

The following table provides information about the project.

Coordinator		 GOETEBORGS UNIVERSITET 

Organization address
address: VASAPARKEN
city: GOETEBORG
postcode: 405 30
website: www.gu.se

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Sweden [SE]
 Project website https://gup.ub.gu.se/publication/269257
 Total cost 185˙857 €
 EC max contribution 185˙857 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-12-01   to  2019-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    GOETEBORGS UNIVERSITET SE (GOETEBORG) coordinator 185˙857.00

Map

 Project objective

Osteoporosis is a major health concern characterized by reduced bone mineral density (BMD) and impaired microarchitecture leading to increased risk of fractures and mortality, especially at the hip. At least 40% of women and 15% of men will sustain one or more fragility fractures in their remaining lifetime, representing a huge economic burden in Europe. Currently available osteoporosis drugs are effective in reducing vertebral fracture risk (dependent on trabecular bone) while less effective for non-vertebral and hip fracture risk (dependent on cortical bone). This proposal aims to identify novel mechanisms regulating site-specific fracture risk, on the basis of recent human genetic findings on the determinants of cortical bone thickness (WNT16 locus) and trabecular volumetric BMD (GREM2 locus). This translational research program will study the role of the WNT lipase NOTUM in the regulation of cortical bone thickness via its interaction with WNT16, a key regulator of cortical bone identified by the proposed supervisor (Nature Medicine 2014). We will next study how the Bone Morphogenetic Protein antagonist GREM2 regulates trabecular BMD. These studies will be performed using genetically modified murine models and human cell-cultures systems. Finally, in a prospective population-based cohort study (n=3010), we will test if serum level of NOTUM predicts the risk of fractures. Our long term goal is to translate these findings into novel biomarkers and more effective therapies for the prevention of osteoporotic fractures. The applicant is an Assistant Professor of Rheumatology with a special clinical focus on osteoporosis and a complementary preclinical research background in osteoarthritis but not osteoporosis. This fellowship in a lab of excellence in the field of translational osteoporosis research will enhance his skills in both bone biology and epidemiological studies and will provide a huge added-value to his academic career with a spectrum of new collaborations.

 Publications

year authors and title journal last update
List of publications.
2018 Thomas Funck-Brentano, Karin H Nilsson, Robert Brommage, Petra Henning, Ulf H Lerner, Antti Koskela, Juha Tuukkanen, Martine Cohen-Solal, Sofia Movérare-Skrtic, Claes Ohlsson
Porcupine inhibitors impair trabecular and cortical bone mass and strength in mice
published pages: 13-23, ISSN: 0022-0795, DOI: 10.1530/JOE-18-0153 		Journal of Endocrinology 238/1 2019-06-11

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