Opendata, web and dolomites

CHUbVi SIGNED

Ubiquitin Chains in Viral Infections

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 CHUbVi project word cloud

Explore the words cloud of the CHUbVi project. It provides you a very rough idea of what is the project "CHUbVi" about.

chains    host    validate    evade    infection    poorly    possibility    mammalian    reduces    antiviral    implicate    tools    agents    animal    exact    despite    cells    blocking    ubiquitin    influenza    immune    ebola    synthesis    basis    line    viruses    zika    utilize    labeled    greatest    broad    spectrum    tested    hosts    preventing    fundamental    offers    generation    molecular    mediators    activate    mechanism    proteins    health    prevalence    clear    infections    nature    diverse    wealth    regulation    society    cellular    compounds    threats    human    investigation    small    particles    dengue    viral    assays    consisting    types    demonstrating    infect    biologist    virologist    infectious    gain    precise    multidisciplinary    biological    life    biochemical    virus    mechanisms    team    interactions    threatening    iav    packaged    therapies    hdac6    formed    anti    unanchored    discovery    danger    mers    insights    structural    downstream    aggresome    molecule    entry    models    chemical   

Project "CHUbVi" data sheet

The following table provides information about the project.

Coordinator
FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION 

Organization address
address: MAULBEERSTRASSE 66
city: BASEL
postcode: 4058
website: www.fmi.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 7˙649˙848 €
 EC max contribution 7˙649˙848 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-SyG
 Funding Scheme ERC-SyG
 Starting year 2020
 Duration (year-month-day) from 2020-03-01   to  2026-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION CH (BASEL) coordinator 2˙698˙125.00
2    UNIVERSITY OF BRISTOL UK (BRISTOL) participant 2˙785˙048.00
3    EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH CH (ZUERICH) participant 2˙166˙675.00

Map

 Project objective

Viruses such as Influenza A (IAV) and others remain one of the greatest threats to human health and society. Despite their danger and widespread prevalence, the molecular mechanisms of how they infect mammalian hosts and evade the immune system remains poorly understood. Recent studies from our team implicate two common proteins – HDAC6 and unanchored ubiquitin chains – in host cells as key mediators of viral entry via the aggresome processing pathway. This discovery offers a new line of investigation for understanding and preventing viral infections.

By identifying the pathways and interactions involved in this infection process, we will provide new molecular targets for the development of broad-spectrum antiviral compounds. Multidisciplinary studies by a team consisting of a molecular biologist, a virologist, and a chemical biologist will use a diverse set of tools to validate these pathways and gain fundamental knowledge about their regulation. To achieve this, detailed studies on the exact nature of the ubiquitin chains needed to activate HDAC6 will allow the development of biochemical and cellular assays of Influenza A infection and enable the determination of the precise mechanism and the downstream cellular pathways necessary for viral infection. The chemical synthesis of labeled ubiquitin chains will support detailed structural studies and a clear understanding of how they are formed and packaged into infectious viral particles. The strong possibility that numerous other virus types also utilize this pathway will be tested with life-threatening agents of current concern including Zika, Dengue, Ebola, and MERS viruses.

By demonstrating – with both biological approaches and small molecule compounds – that blocking these cellular processes in cells and animal models reduces viral infection, this project will provide a wealth a novel insights and the basis for the development of a new generation of anti-viral therapies.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "CHUBVI" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "CHUBVI" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

LO-KMOF (2019)

Vapour-deposited metal-organic frameworks as high-performance gap-filling dielectrics for nanoelectronics

Read More  

TRUST (2018)

Truth and Semantics

Read More  

PLAT_ACE (2019)

A new platform technology for the on-demand access to large acenes

Read More