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CHUbVi SIGNED

Ubiquitin Chains in Viral Infections

Total Cost €

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EC-Contrib. €

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Partnership

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 CHUbVi project word cloud

Explore the words cloud of the CHUbVi project. It provides you a very rough idea of what is the project "CHUbVi" about.

aggresome    therapies    hdac6    investigation    immune    gain    compounds    chemical    viruses    reduces    formed    anti    mediators    clear    biological    discovery    assays    zika    poorly    validate    evade    animal    structural    virologist    possibility    implicate    molecule    downstream    insights    infectious    virus    greatest    dengue    proteins    threatening    activate    wealth    infect    diverse    biologist    regulation    mammalian    small    mechanisms    host    infection    society    models    infections    broad    utilize    antiviral    threats    viral    chains    offers    cellular    mers    prevalence    health    ubiquitin    life    mechanism    unanchored    blocking    spectrum    basis    particles    team    nature    types    interactions    cells    multidisciplinary    danger    agents    demonstrating    molecular    synthesis    exact    generation    entry    preventing    ebola    human    influenza    fundamental    biochemical    hosts    tested    consisting    despite    iav    precise    labeled    tools    line    packaged   

Project "CHUbVi" data sheet

The following table provides information about the project.

Coordinator
FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION 

Organization address
address: MAULBEERSTRASSE 66
city: BASEL
postcode: 4058
website: www.fmi.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 7˙649˙848 €
 EC max contribution 7˙649˙848 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-SyG
 Funding Scheme ERC-SyG
 Starting year 2020
 Duration (year-month-day) from 2020-03-01   to  2026-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION CH (BASEL) coordinator 2˙698˙125.00
2    UNIVERSITY OF BRISTOL UK (BRISTOL) participant 2˙785˙048.00
3    EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH CH (ZUERICH) participant 2˙166˙675.00

Map

 Project objective

Viruses such as Influenza A (IAV) and others remain one of the greatest threats to human health and society. Despite their danger and widespread prevalence, the molecular mechanisms of how they infect mammalian hosts and evade the immune system remains poorly understood. Recent studies from our team implicate two common proteins – HDAC6 and unanchored ubiquitin chains – in host cells as key mediators of viral entry via the aggresome processing pathway. This discovery offers a new line of investigation for understanding and preventing viral infections.

By identifying the pathways and interactions involved in this infection process, we will provide new molecular targets for the development of broad-spectrum antiviral compounds. Multidisciplinary studies by a team consisting of a molecular biologist, a virologist, and a chemical biologist will use a diverse set of tools to validate these pathways and gain fundamental knowledge about their regulation. To achieve this, detailed studies on the exact nature of the ubiquitin chains needed to activate HDAC6 will allow the development of biochemical and cellular assays of Influenza A infection and enable the determination of the precise mechanism and the downstream cellular pathways necessary for viral infection. The chemical synthesis of labeled ubiquitin chains will support detailed structural studies and a clear understanding of how they are formed and packaged into infectious viral particles. The strong possibility that numerous other virus types also utilize this pathway will be tested with life-threatening agents of current concern including Zika, Dengue, Ebola, and MERS viruses.

By demonstrating – with both biological approaches and small molecule compounds – that blocking these cellular processes in cells and animal models reduces viral infection, this project will provide a wealth a novel insights and the basis for the development of a new generation of anti-viral therapies.

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The information about "CHUBVI" are provided by the European Opendata Portal: CORDIS opendata.

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