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BioMatrix SIGNED

Structural Biology of Exopolysaccharide Secretion in Bacterial Biofilms

Total Cost €

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EC-Contrib. €

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Partnership

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 BioMatrix project word cloud

Explore the words cloud of the BioMatrix project. It provides you a very rough idea of what is the project "BioMatrix" about.

infectives    crystallography    science    model    structure    therapeutics    team    dna    organisms    biofilm    negative    pseudomonas    gmp    biology    laid    microbiology    architecture    exporters    exchange    spans    escherichia    intercellular    view    expertise    biogenesis    ph    mechanical    biophysical    cellulo    initiation    individual    building    matrix    compelling    assays    species    functional    global    producing    resistance    blueprints    electron    biofilms    combine    gram    determinants    bacterial    ray    exopolysaccharide    protein    intracellular    membrane    demonstrated    post    medium    biochemical    horizontal    developmental    secretion    doctoral    inside    macrocolonies    coli    aeruginosa    reveal    vibrio    components    collaborative    anti    signalling    megacomplexes    persistence    antibiotic    transcription    messenger    paramount    feasibility    extracellular    microscopy    expolysaccharide    cell    gene    resolution    pathogen    di    last    secures    levels    platforms    structural    binding    pathogens    downstream    disease    indirectly    positive    mechanisms    foundation    molecular    sensing    transfer    envelope    sessile    controling    function    spp   

Project "BioMatrix" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙499˙901 €
 EC max contribution 1˙499˙901 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-08-01   to  2023-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 1˙499˙901.00

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 Project objective

Bacterial biofilm formation is a paramount developmental process in both Gram-positive and Gram-negative species and in many pathogens has been associated with processes of horizontal gene transfer, antibiotic resistance development and pathogen persistence. Bacterial biofilms are collaborative sessile macrocolonies embedded in complex extracellular matrix that secures both mechanical resistance and a medium for intercellular exchange.

Biogenesis platforms for the secretion of biofilm matrix components - many of which controlled directly or indirectly by the intracellular second messenger c-di-GMP - are important determinants for biofilm formation and bacterial disease, and therefore present compelling targets for the development of novel therapeutics. During my Ph.D. and post-doctoral work I studied the structure and function of c-di-GMP-sensing protein factors controling extracellular matrix production by DNA-binding at the transcription initiation level or by inside-out signalling mechanisms at the cell envelope, as well as membrane exporters involved directly in downstream matrix component secretion.

Here, I propose to apply my expertise in microbiology, protein science and structural biology to study the structure and function of exopolysaccharide secretion systems in Gram-negative species. Using Pseudomonas aeruginosa, Vibrio spp. and Escherichia coli as model organisms, my team will aim to reveal the global architecture and individual building components of several expolysaccharide-producing protein megacomplexes. We will combine X-ray crystallography, biophysical and biochemical assays, electron microscopy and in cellulo functional studies to provide a comprehensive view of extracellular matrix production that spans the different resolution levels and presents molecular blueprints for the development of novel anti-infectives. Over the last year I have laid the foundation of these studies and have demonstrated the overall feasibility of the project.

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The information about "BIOMATRIX" are provided by the European Opendata Portal: CORDIS opendata.

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