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BioMatrix SIGNED

Structural Biology of Exopolysaccharide Secretion in Bacterial Biofilms

Total Cost €

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EC-Contrib. €

0

Partnership

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 BioMatrix project word cloud

Explore the words cloud of the BioMatrix project. It provides you a very rough idea of what is the project "BioMatrix" about.

exporters    structure    organisms    functional    gene    ph    biophysical    extracellular    last    exopolysaccharide    gram    demonstrated    signalling    components    binding    antibiotic    post    matrix    biology    sessile    secretion    compelling    persistence    microbiology    positive    gmp    therapeutics    expolysaccharide    protein    vibrio    pathogens    individual    macrocolonies    membrane    developmental    team    aeruginosa    transcription    intercellular    downstream    determinants    reveal    exchange    messenger    di    mechanical    building    controling    structural    laid    ray    producing    intracellular    biofilms    levels    secures    dna    horizontal    cellulo    cell    crystallography    paramount    blueprints    spans    science    disease    megacomplexes    biogenesis    assays    biochemical    mechanisms    feasibility    molecular    coli    infectives    collaborative    electron    envelope    microscopy    foundation    combine    spp    escherichia    negative    function    medium    sensing    species    pathogen    resistance    expertise    anti    platforms    inside    pseudomonas    bacterial    architecture    global    biofilm    model    transfer    indirectly    initiation    resolution    doctoral    view   

Project "BioMatrix" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙499˙901 €
 EC max contribution 1˙499˙901 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-08-01   to  2023-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 1˙499˙901.00

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 Project objective

Bacterial biofilm formation is a paramount developmental process in both Gram-positive and Gram-negative species and in many pathogens has been associated with processes of horizontal gene transfer, antibiotic resistance development and pathogen persistence. Bacterial biofilms are collaborative sessile macrocolonies embedded in complex extracellular matrix that secures both mechanical resistance and a medium for intercellular exchange.

Biogenesis platforms for the secretion of biofilm matrix components - many of which controlled directly or indirectly by the intracellular second messenger c-di-GMP - are important determinants for biofilm formation and bacterial disease, and therefore present compelling targets for the development of novel therapeutics. During my Ph.D. and post-doctoral work I studied the structure and function of c-di-GMP-sensing protein factors controling extracellular matrix production by DNA-binding at the transcription initiation level or by inside-out signalling mechanisms at the cell envelope, as well as membrane exporters involved directly in downstream matrix component secretion.

Here, I propose to apply my expertise in microbiology, protein science and structural biology to study the structure and function of exopolysaccharide secretion systems in Gram-negative species. Using Pseudomonas aeruginosa, Vibrio spp. and Escherichia coli as model organisms, my team will aim to reveal the global architecture and individual building components of several expolysaccharide-producing protein megacomplexes. We will combine X-ray crystallography, biophysical and biochemical assays, electron microscopy and in cellulo functional studies to provide a comprehensive view of extracellular matrix production that spans the different resolution levels and presents molecular blueprints for the development of novel anti-infectives. Over the last year I have laid the foundation of these studies and have demonstrated the overall feasibility of the project.

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The information about "BIOMATRIX" are provided by the European Opendata Portal: CORDIS opendata.

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