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BioMatrix SIGNED

Structural Biology of Exopolysaccharide Secretion in Bacterial Biofilms

Total Cost €

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EC-Contrib. €

0

Partnership

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 BioMatrix project word cloud

Explore the words cloud of the BioMatrix project. It provides you a very rough idea of what is the project "BioMatrix" about.

paramount    initiation    secretion    pathogen    last    transfer    producing    persistence    disease    demonstrated    downstream    escherichia    di    determinants    biochemical    sessile    infectives    ph    combine    biogenesis    cell    resolution    cellulo    science    negative    controling    building    inside    electron    resistance    ray    platforms    molecular    doctoral    compelling    post    organisms    exporters    gene    signalling    architecture    expolysaccharide    reveal    feasibility    bacterial    model    binding    transcription    biofilms    assays    dna    structure    megacomplexes    spans    intercellular    crystallography    blueprints    structural    expertise    global    gmp    foundation    anti    biofilm    laid    biophysical    macrocolonies    spp    functional    components    messenger    collaborative    biology    species    levels    intracellular    protein    pathogens    antibiotic    sensing    function    mechanical    developmental    aeruginosa    envelope    secures    microbiology    extracellular    mechanisms    matrix    team    positive    gram    therapeutics    exchange    membrane    indirectly    vibrio    view    pseudomonas    microscopy    individual    coli    medium    exopolysaccharide    horizontal   

Project "BioMatrix" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙499˙901 €
 EC max contribution 1˙499˙901 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-08-01   to  2023-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 1˙499˙901.00

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 Project objective

Bacterial biofilm formation is a paramount developmental process in both Gram-positive and Gram-negative species and in many pathogens has been associated with processes of horizontal gene transfer, antibiotic resistance development and pathogen persistence. Bacterial biofilms are collaborative sessile macrocolonies embedded in complex extracellular matrix that secures both mechanical resistance and a medium for intercellular exchange.

Biogenesis platforms for the secretion of biofilm matrix components - many of which controlled directly or indirectly by the intracellular second messenger c-di-GMP - are important determinants for biofilm formation and bacterial disease, and therefore present compelling targets for the development of novel therapeutics. During my Ph.D. and post-doctoral work I studied the structure and function of c-di-GMP-sensing protein factors controling extracellular matrix production by DNA-binding at the transcription initiation level or by inside-out signalling mechanisms at the cell envelope, as well as membrane exporters involved directly in downstream matrix component secretion.

Here, I propose to apply my expertise in microbiology, protein science and structural biology to study the structure and function of exopolysaccharide secretion systems in Gram-negative species. Using Pseudomonas aeruginosa, Vibrio spp. and Escherichia coli as model organisms, my team will aim to reveal the global architecture and individual building components of several expolysaccharide-producing protein megacomplexes. We will combine X-ray crystallography, biophysical and biochemical assays, electron microscopy and in cellulo functional studies to provide a comprehensive view of extracellular matrix production that spans the different resolution levels and presents molecular blueprints for the development of novel anti-infectives. Over the last year I have laid the foundation of these studies and have demonstrated the overall feasibility of the project.

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The information about "BIOMATRIX" are provided by the European Opendata Portal: CORDIS opendata.

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