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BioMatrix SIGNED

Structural Biology of Exopolysaccharide Secretion in Bacterial Biofilms

Total Cost €

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EC-Contrib. €

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Partnership

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 BioMatrix project word cloud

Explore the words cloud of the BioMatrix project. It provides you a very rough idea of what is the project "BioMatrix" about.

secretion    messenger    laid    extracellular    signalling    exopolysaccharide    individual    intracellular    microbiology    coli    biochemical    macrocolonies    gmp    global    gram    downstream    science    molecular    sessile    protein    electron    gene    building    resolution    secures    persistence    di    binding    membrane    foundation    producing    controling    transfer    positive    disease    intercellular    aeruginosa    envelope    initiation    architecture    negative    levels    biofilms    blueprints    compelling    exchange    inside    mechanical    horizontal    structure    therapeutics    transcription    doctoral    combine    reveal    structural    spans    crystallography    organisms    expolysaccharide    escherichia    medium    species    paramount    team    resistance    matrix    functional    developmental    post    cellulo    ray    components    biophysical    cell    megacomplexes    expertise    antibiotic    biofilm    pseudomonas    vibrio    pathogen    biogenesis    view    assays    mechanisms    sensing    feasibility    indirectly    demonstrated    determinants    exporters    last    platforms    spp    biology    ph    infectives    bacterial    model    anti    collaborative    function    microscopy    pathogens    dna   

Project "BioMatrix" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙499˙901 €
 EC max contribution 1˙499˙901 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-08-01   to  2023-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 1˙499˙901.00

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 Project objective

Bacterial biofilm formation is a paramount developmental process in both Gram-positive and Gram-negative species and in many pathogens has been associated with processes of horizontal gene transfer, antibiotic resistance development and pathogen persistence. Bacterial biofilms are collaborative sessile macrocolonies embedded in complex extracellular matrix that secures both mechanical resistance and a medium for intercellular exchange.

Biogenesis platforms for the secretion of biofilm matrix components - many of which controlled directly or indirectly by the intracellular second messenger c-di-GMP - are important determinants for biofilm formation and bacterial disease, and therefore present compelling targets for the development of novel therapeutics. During my Ph.D. and post-doctoral work I studied the structure and function of c-di-GMP-sensing protein factors controling extracellular matrix production by DNA-binding at the transcription initiation level or by inside-out signalling mechanisms at the cell envelope, as well as membrane exporters involved directly in downstream matrix component secretion.

Here, I propose to apply my expertise in microbiology, protein science and structural biology to study the structure and function of exopolysaccharide secretion systems in Gram-negative species. Using Pseudomonas aeruginosa, Vibrio spp. and Escherichia coli as model organisms, my team will aim to reveal the global architecture and individual building components of several expolysaccharide-producing protein megacomplexes. We will combine X-ray crystallography, biophysical and biochemical assays, electron microscopy and in cellulo functional studies to provide a comprehensive view of extracellular matrix production that spans the different resolution levels and presents molecular blueprints for the development of novel anti-infectives. Over the last year I have laid the foundation of these studies and have demonstrated the overall feasibility of the project.

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The information about "BIOMATRIX" are provided by the European Opendata Portal: CORDIS opendata.

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