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BioMatrix SIGNED

Structural Biology of Exopolysaccharide Secretion in Bacterial Biofilms

Total Cost €

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EC-Contrib. €

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Partnership

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 BioMatrix project word cloud

Explore the words cloud of the BioMatrix project. It provides you a very rough idea of what is the project "BioMatrix" about.

architecture    megacomplexes    biofilms    species    structure    expolysaccharide    indirectly    functional    cell    cellulo    view    mechanical    secretion    platforms    persistence    antibiotic    controling    blueprints    microscopy    mechanisms    anti    crystallography    pathogen    dna    gene    vibrio    collaborative    spans    ray    producing    exopolysaccharide    function    gmp    resistance    exporters    bacterial    microbiology    electron    pathogens    organisms    resolution    paramount    determinants    initiation    molecular    team    gram    escherichia    demonstrated    di    negative    biology    downstream    last    global    macrocolonies    expertise    intracellular    coli    sensing    ph    binding    biochemical    aeruginosa    model    messenger    building    levels    transcription    biophysical    pseudomonas    protein    spp    developmental    intercellular    exchange    science    combine    assays    matrix    disease    structural    secures    positive    inside    foundation    biofilm    medium    doctoral    membrane    horizontal    reveal    therapeutics    individual    extracellular    infectives    feasibility    envelope    compelling    signalling    post    components    transfer    biogenesis    laid    sessile   

Project "BioMatrix" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙499˙901 €
 EC max contribution 1˙499˙901 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-08-01   to  2023-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 1˙499˙901.00

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 Project objective

Bacterial biofilm formation is a paramount developmental process in both Gram-positive and Gram-negative species and in many pathogens has been associated with processes of horizontal gene transfer, antibiotic resistance development and pathogen persistence. Bacterial biofilms are collaborative sessile macrocolonies embedded in complex extracellular matrix that secures both mechanical resistance and a medium for intercellular exchange.

Biogenesis platforms for the secretion of biofilm matrix components - many of which controlled directly or indirectly by the intracellular second messenger c-di-GMP - are important determinants for biofilm formation and bacterial disease, and therefore present compelling targets for the development of novel therapeutics. During my Ph.D. and post-doctoral work I studied the structure and function of c-di-GMP-sensing protein factors controling extracellular matrix production by DNA-binding at the transcription initiation level or by inside-out signalling mechanisms at the cell envelope, as well as membrane exporters involved directly in downstream matrix component secretion.

Here, I propose to apply my expertise in microbiology, protein science and structural biology to study the structure and function of exopolysaccharide secretion systems in Gram-negative species. Using Pseudomonas aeruginosa, Vibrio spp. and Escherichia coli as model organisms, my team will aim to reveal the global architecture and individual building components of several expolysaccharide-producing protein megacomplexes. We will combine X-ray crystallography, biophysical and biochemical assays, electron microscopy and in cellulo functional studies to provide a comprehensive view of extracellular matrix production that spans the different resolution levels and presents molecular blueprints for the development of novel anti-infectives. Over the last year I have laid the foundation of these studies and have demonstrated the overall feasibility of the project.

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The information about "BIOMATRIX" are provided by the European Opendata Portal: CORDIS opendata.

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