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Life-Cycle SIGNED

Life-like Supramolecular Materials based on Reaction Cycles with Designed Feedback

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EC-Contrib. €

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Project "Life-Cycle" data sheet

The following table provides information about the project.

Coordinator
CENTRE INTERNATIONAL DE RECHERCHE AUX FRONTIERES DE LA CHIMIE FONDATION 

Organization address
address: ALLEE G MONGE 8
city: STRASBOURG
postcode: 67000
website: http://www.icfrc.fr/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙762˙488 €
 EC max contribution 1˙762˙488 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-01-01   to  2022-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE INTERNATIONAL DE RECHERCHE AUX FRONTIERES DE LA CHIMIE FONDATION FR (STRASBOURG) coordinator 1˙762˙488.00

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 Project objective

This “Life-Cycle” ERC proposal aims to develop a new class of artificial supramolecular materials that are kept in sustained non-equilibrium states by continuous dissipation of chemical fuels. Supramolecular polymers in current artificial materials stick together through weak reversible bonds that can be exchange by thermal energy. In contrast, natural supramolecular polymers such as those in the cytoskeletal network use chemical fuels such as adenosine triphosphate (ATP) to achieve an incredible adaptivity, motility, growth, and response to external inputs. Development of chemically fueled artificial supramolecular polymers should therefore lead to more life-like materials that could perform functions so far reserved only for living beings. The proposed materials are based on supramolecular reaction cycles that have both positive and negative feedback in order to achieve emergent properties, such as oscillations and waves. Two different approaches are used: i) supramolecular polymers that are fueled by redox reactions, and ii) enzyme-switchable supramolecular polymers that consume one of the natural fuels, namely ATP. The proposed polymers self-assemble cooperatively, which is used as a positive feedback mechanism. Using other co-assembling species we can engineer negative feedback in our reaction cycles to obtain unique supramolecular dynamics. Since the building blocks react, but also self-assemble they have built-in chemomechanical properties, much like in living materials such as the cytoskeleton. First we study the temporal behavior (part A) of our reaction cycles in well-stirred environments. Next, we move to non-stirred conditions (part B), where spatiotemporal behavior can be studied. And lastly, we develop free-standing non-equilibrium interactive materials based on our reaction cycles (part C). Overall, our approach opens a new way to obtain more life-like artificial materials that can eventually perform complex (biological) functions.

 Publications

year authors and title journal last update
List of publications.
2018 Jorge Leira-Iglesias, Alessandra Tassoni, Takuji Adachi, Michael Stich, Thomas M. Hermans
Oscillations, travelling fronts and patterns in a supramolecular system
published pages: 1021-1027, ISSN: 1748-3387, DOI: 10.1038/s41565-018-0270-4
Nature Nanotechnology 13/11 2019-10-07
2018 Daniel Spitzer, Vincent Marichez, Georges J. M. Formon, Pol Besenius, Thomas M. Hermans
Surface-Assisted Self-Assembly of a Hydrogel by Proton Diffusion
published pages: 11349-11353, ISSN: 1433-7851, DOI: 10.1002/anie.201806668
Angewandte Chemie International Edition 57/35 2019-09-09

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