Opendata, web and dolomites

enzC-Hem SIGNED

Creating Versatile Metallo-Enzyme Environments for Selective C-H Activation Chemistry: Lignocellulose Deconstruction and Beyond

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 enzC-Hem project word cloud

Explore the words cloud of the enzC-Hem project. It provides you a very rough idea of what is the project "enzC-Hem" about.

genetic    precisely    versatile    variants    perfectly    molecular    lignocellulose    chemically    molecules    gt    evolution    hem    severely    systematically    strategies    revealing    profiles    expanded    activation    organic    supporting    small    proteins    laboratory    streamlined    environments    revolutionize    programmed    synthetic    catalysts    chemicals    stage    impressive    twenty    acid    platform    site    recognition    ing    aspirational    catalyst    ligands    limiting    augmented    metal    chemistry    alphabet    engineering    ultra    determined    noble    substrate    industry    molecule    tuned    readily    protein    catalytic    enzc    modern    biofuel    transformations    functionalizations    limited    orientation    chemical    nature    global    bonds    biotechnology    alter    enzyme    precise    ordination    yielding    biocatalysts    install    selectivity    greener    co    code    directed    routes    scaffolds    bioactive    broad    transition    amino    accessible    throughput    optimized    functionalize    complexes    merges    individual   

Project "enzC-Hem" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF MANCHESTER 

Organization address
address: OXFORD ROAD
city: MANCHESTER
postcode: M13 9PL
website: www.manchester.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 1˙492˙424 €
 EC max contribution 1˙492˙424 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-01-01   to  2022-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF MANCHESTER UK (MANCHESTER) coordinator 1˙492˙424.00

Map

 Project objective

The availability of a versatile catalytic platform to precisely target and functionalize individual C-H bonds in complex organic molecules would revolutionize our synthetic strategies, leading to streamlined routes to high value chemicals and supporting the development of a ‘greener’ chemical industry. Although an impressive range of C-H functionalizations can be achieved with small transition metal complexes, site selectivity is often determined by features of the substrate, and not by the catalyst. A general approach to achieve the more aspirational ‘catalyst controlled’ transformations requires molecular recognition elements within the catalyst which: a) allow precise substrate orientation and b) can be tuned to alter selectivity. In principle, these requirements could be perfectly addressed by protein catalysts which can be readily adapted via laboratory evolution. However, enzyme engineering strategies are currently limited to Nature’s twenty amino acid alphabet, severely limiting the range of metal co-ordination environments, and thus catalytic activities, that are accessible within proteins. In enzC-Hem, I will exploit advanced protein engineering technology available in my laboratory to install ‘chemically programmed’ ligands and/or noble metal co-factors into selected enzyme scaffolds. I will show that the resulting C-H activation catalysts can be systematically optimized via directed evolution with an expanded genetic code using modern ultra-high throughput methods (>100 variants per second), yielding biocatalysts with augmented selectivity/activity profiles. Thus my approach merges the broad range of C-H functionalizations accessible with small molecule catalysts with precise control of selectivity provided by proteins. The biocatalysts developed will address major global challenges in biotechnology and synthetic chemistry, from enhancing lignocellulose derived biofuel production to revealing novel bioactive molecules via late-stage functionalizations.

 Publications

year authors and title journal last update
List of publications.
2018 Moritz Pott, Takahiro Hayashi, Takahiro Mori, Peer R. E. Mittl, Anthony P. Green, Donald Hilvert
A Noncanonical Proximal Heme Ligand Affords an Efficient Peroxidase in a Globin Fold
published pages: 1535-1543, ISSN: 0002-7863, DOI: 10.1021/jacs.7b12621
Journal of the American Chemical Society 140/4 2019-08-29
2018 Takahiro Hayashi, Donald Hilvert, Anthony P. Green
Engineered Metalloenzymes with Non‐Canonical Coordination Environments
published pages: 11821-11830, ISSN: 0947-6539, DOI: 10.1002/chem.201800975
Chemistry – A European Journal 24/46 2019-08-29
2019 Ashleigh J. Burke, Sarah L. Lovelock, Amina Frese, Rebecca Crawshaw, Mary Ortmayer, Mark Dunstan, Colin Levy, Anthony P. Green
Design and evolution of an enzyme with a non-canonical organocatalytic mechanism
published pages: 219-223, ISSN: 0028-0836, DOI: 10.1038/s41586-019-1262-8
Nature 570/7760 2019-08-29
2018 Jin Xu, Anthony P. Green, Nicholas J. Turner
Chemo-Enzymatic Synthesis of Pyrazines and Pyrroles
published pages: 16760-16763, ISSN: 1433-7851, DOI: 10.1002/anie.201810555
Angewandte Chemie International Edition 57/51 2019-08-29

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "ENZC-HEM" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "ENZC-HEM" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

ENTRAPMENT (2019)

Septins: from bacterial entrapment to cellular immunity

Read More  

EVOCELFATE (2019)

Evolution of cell fate specification modes in spiral cleavage

Read More  

CellularLogistics (2019)

Cellular Logistics: Form, Formation and Function of the Neuronal Microtubule Cytoskeleton

Read More