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NeuroMag SIGNED

The Neurological Basis of the Magnetic Sense

Total Cost €

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EC-Contrib. €

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Partnership

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 NeuroMag project word cloud

Explore the words cloud of the NeuroMag project. It provides you a very rough idea of what is the project "NeuroMag" about.

behavioural    coupled    neurons    detection    dynamic    activation    animals    putative    assay    picture    infrastructure    electroreceptors    locate    cellular    experiments    depends    physical    hemispheres    magnetosensitive    model    situation    inner    encoded    nature    processed    magnetite    brain    methodology    ear    restricted    stimuli    sensors    questions    hair    unequivocal    oceans    utilising    kept    least    ensembles    millions    sensory    migratory    electromagnetic    biophysical    components    intensity    inclination    pigeon    primary    induction    neurological    guided    circuits    vivo    existence    clearing    explore    journeys    transcriptomic    anticipate    detect    complement    magnetically    secret    encode    mapping    earth    microscopy    photon    light    magnetosensors    polarity    molecularly    sheet    molecular    remedy    sense    magnetic    underpinnings    cells    demonstrating    pigeons    faculties    remarkable    hidden    each    anatomically    opaque    neuronal    millennia    employ    crystals    reveal   

Project "NeuroMag" data sheet

The following table provides information about the project.

Coordinator
FORSCHUNGSINSTITUT FUR MOLEKULARE PATHOLOGIE GESELLSCHAFT MBH 

Organization address
address: CAMPUS-VIENNA-BIOCENTER 1
city: WIEN
postcode: 1030
website: www.imp.ac.at

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Austria [AT]
 Total cost 1˙990˙376 €
 EC max contribution 1˙990˙376 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-COG
 Funding Scheme ERC-COG
 Starting year 2019
 Duration (year-month-day) from 2019-10-01   to  2024-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FORSCHUNGSINSTITUT FUR MOLEKULARE PATHOLOGIE GESELLSCHAFT MBH AT (WIEN) coordinator 1˙990˙376.00

Map

 Project objective

Each year millions of animals undertake remarkable migratory journeys, across oceans and through hemispheres, guided by the Earth’s magnetic field. While there is unequivocal behavioural evidence demonstrating the existence of the magnetic sense, it is the least understood of all sensory faculties. The biophysical, molecular, cellular, and neurological underpinnings of the sense remain opaque. In this application we aim to remedy this situation, exploiting an established assay, our unique infrastructure, and state-of-the-art methodology, using pigeons as a model system. The proposal will address three questions:

1) Where are the primary magnetosensors? 2) Where is magnetic information processed in the brain? 3) How is magnetic information encoded in the brain?

In Aim 1 we will explore whether inner ear hair cells are the primary sensors, and if the detection of magnetic stimuli depends on the presence of magnetic crystals or electromagnetic induction. We will employ a range of physical methods to locate magnetite, and a molecular approach to identify putative electroreceptors. In Aim 2 we will use light sheet microscopy coupled with clearing methods to undertake whole brain mapping of magnetically-induced neuronal activation in the pigeon. We will complement these studies with transcriptomic methods to molecularly and anatomically define magnetosensitive circuits within the pigeon brain. We will build on this work in Aim 3 utilising in vivo 2-photon microscopy to investigate how cells within the pigeon brain encode magnetic information. We will determine whether neurons encode for specific components of the magnetic field (i.e. inclination, intensity, and polarity) and explore whether there are spatially restricted ensembles, providing a dynamic picture of magnetically induced neuronal activity. We anticipate that these experiments will reveal a secret that nature has kept hidden for millennia; How do animals detect magnetic fields?

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The information about "NEUROMAG" are provided by the European Opendata Portal: CORDIS opendata.

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