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NeuroMag SIGNED

The Neurological Basis of the Magnetic Sense

Total Cost €

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EC-Contrib. €

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Partnership

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 NeuroMag project word cloud

Explore the words cloud of the NeuroMag project. It provides you a very rough idea of what is the project "NeuroMag" about.

oceans    explore    anticipate    infrastructure    detection    brain    processed    ear    electromagnetic    polarity    guided    hair    encode    behavioural    situation    magnetite    reveal    light    underpinnings    vivo    journeys    activation    hemispheres    millions    kept    photon    neurological    inclination    complement    experiments    encoded    cellular    molecularly    demonstrating    crystals    components    magnetosensors    dynamic    migratory    unequivocal    pigeons    cells    sense    anatomically    opaque    putative    circuits    remarkable    each    detect    clearing    existence    model    transcriptomic    employ    remedy    physical    molecular    microscopy    primary    faculties    methodology    magnetosensitive    sensors    induction    hidden    millennia    secret    stimuli    ensembles    magnetic    picture    sheet    restricted    questions    magnetically    electroreceptors    mapping    utilising    biophysical    pigeon    earth    intensity    locate    neuronal    depends    sensory    inner    coupled    least    nature    assay    neurons    animals   

Project "NeuroMag" data sheet

The following table provides information about the project.

Coordinator
FORSCHUNGSINSTITUT FUR MOLEKULARE PATHOLOGIE GESELLSCHAFT MBH 

Organization address
address: CAMPUS-VIENNA-BIOCENTER 1
city: WIEN
postcode: 1030
website: www.imp.ac.at

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Austria [AT]
 Total cost 1˙990˙376 €
 EC max contribution 1˙990˙376 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-COG
 Funding Scheme ERC-COG
 Starting year 2019
 Duration (year-month-day) from 2019-10-01   to  2024-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FORSCHUNGSINSTITUT FUR MOLEKULARE PATHOLOGIE GESELLSCHAFT MBH AT (WIEN) coordinator 1˙990˙376.00

Map

 Project objective

Each year millions of animals undertake remarkable migratory journeys, across oceans and through hemispheres, guided by the Earth’s magnetic field. While there is unequivocal behavioural evidence demonstrating the existence of the magnetic sense, it is the least understood of all sensory faculties. The biophysical, molecular, cellular, and neurological underpinnings of the sense remain opaque. In this application we aim to remedy this situation, exploiting an established assay, our unique infrastructure, and state-of-the-art methodology, using pigeons as a model system. The proposal will address three questions:

1) Where are the primary magnetosensors? 2) Where is magnetic information processed in the brain? 3) How is magnetic information encoded in the brain?

In Aim 1 we will explore whether inner ear hair cells are the primary sensors, and if the detection of magnetic stimuli depends on the presence of magnetic crystals or electromagnetic induction. We will employ a range of physical methods to locate magnetite, and a molecular approach to identify putative electroreceptors. In Aim 2 we will use light sheet microscopy coupled with clearing methods to undertake whole brain mapping of magnetically-induced neuronal activation in the pigeon. We will complement these studies with transcriptomic methods to molecularly and anatomically define magnetosensitive circuits within the pigeon brain. We will build on this work in Aim 3 utilising in vivo 2-photon microscopy to investigate how cells within the pigeon brain encode magnetic information. We will determine whether neurons encode for specific components of the magnetic field (i.e. inclination, intensity, and polarity) and explore whether there are spatially restricted ensembles, providing a dynamic picture of magnetically induced neuronal activity. We anticipate that these experiments will reveal a secret that nature has kept hidden for millennia; How do animals detect magnetic fields?

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The information about "NEUROMAG" are provided by the European Opendata Portal: CORDIS opendata.

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