Explore the words cloud of the Drug the bug project. It provides you a very rough idea of what is the project "Drug the bug" about.
The following table provides information about the project.
|Coordinator Country||Sweden [SE]|
|Total cost||149˙700 €|
|EC max contribution||149˙700 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2017-12-01 to 2019-05-31|
Take a look of project's partnership.
|1||GOETEBORGS UNIVERSITET||SE (GOETEBORG)||coordinator||149˙700.00|
The gut microbiota has been associated with metabolic diseases, such as type 2 diabetes. In my ERC consolidator award we demonstrated that the gut microbiota is altered following bariatric surgery and that the altered microbiota may be directly linked to some of the metabolic improvements observed following surgery. Interestingly, improved metabolism was associated with altered metabolite production capacity from the microbiota and we observed that a metabolite, imidazole propionate, was reduced after surgery. In associated projects we have demonstrated that imidazole propionate is associated with type 2 diabetes in humans and induce insulin resistance in primary hepatocytes and when injected into mice. Imidazole propionate is synthesized by the microbial enzyme UrdA from histidine. This POC will explore the potential of identifying inhibitors of UrdA to reduce production of imidazole propionate and thereby improve insulin sensitivity. If successful we envision a new class of diabetes medication based on the concept of drug the bug.
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The information about "DRUG THE BUG" are provided by the European Opendata Portal: CORDIS opendata.