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MERLIN SIGNED

Multi-modal, multi-scale retinal imaging

Total Cost €

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EC-Contrib. €

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Partnership

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 MERLIN project word cloud

Explore the words cloud of the MERLIN project. It provides you a very rough idea of what is the project "MERLIN" about.

follow    difficult    techniques    pathological    dimensions    oct    medical    translate    limitations    diabetes    enhanced    scales    fp7    diabetic    alterations    reveal    age    adaptive    investigation    retinopathy    time    sensitivity    preexisting    diagnosis    eye    ultrafast    laser    resolution    pathologies    chronic    software    specificity    experimentations    ambition    ophthalmoscopy    vascular    degeneration    multiple    blindness    2012    hinders    commercial    trials    cellular    slowly    nearly    feasibility    tomography    therapies    retinal    takes    examine    therapeutic    performance    optimize    optical    optics    microvascular    retina    coherence    device    scanning    laboratory    usable    previously    prototype    macroscopic    clinical    worldwide    conduct    angiography    amd    microscopic    quantitative    visualization    imaging    invisible    demonstrated    validate    people    macular    ultrahigh    diseases    overcome    structures    diagnostic    merlin    stage    modalities    detect    first    dr    famos    2017    doctors    combination    slo    treatments    image    55    months    patients   

Project "MERLIN" data sheet

The following table provides information about the project.

Coordinator
IMAGINE EYES SA 

Organization address
address: RUE CHARLES DE GAULLE 18
city: ORSAY
postcode: 91400
website: www.imagine-eyes.com

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Project website https://www.imagine-eyes.com/merlin/
 Total cost 5˙678˙335 €
 EC max contribution 4˙867˙660 € (86%)
 Programme 1. H2020-EU.2.1.1. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Information and Communication Technologies (ICT))
 Code Call H2020-ICT-2017-1
 Funding Scheme IA
 Starting year 2017
 Duration (year-month-day) from 2017-12-01   to  2020-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    IMAGINE EYES SA FR (ORSAY) coordinator 1˙891˙575.00
2    ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM NL (ROTTERDAM) participant 1˙072˙825.00
3    MEDIZINISCHE UNIVERSITAET WIEN AT (WIEN) participant 588˙025.00
4    FUNDACIO INSTITUT DE CIENCIES FOTONIQUES ES (Castelldefels) participant 522˙500.00
5    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) participant 431˙000.00
6    REGION HOVEDSTADEN DK (HILLEROD) participant 361˙735.00

Map

 Project objective

The ambition of the MERLIN project is to improve in-depth diagnosis and therapeutic follow-up of diseases that impact the eye’s retina. To do so, the MERLIN partners will deliver a novel medical imaging device able to detect pathological alterations in the retina with highly enhanced sensitivity and specificity. The medical applications of this device encompass a wide range of retinal pathologies, including age-related macular degeneration (AMD), as well as chronic vascular conditions, including diabetes. AMD and diabetic retinopathy (DR) are the leading cause of blindness worldwide in people over 55 years of age. Such diseases slowly develop at the microscopic scale in the retina. Using current imaging techniques, it is difficult to detect them at early stage, and it often takes months to assess the effects of treatments. These limitations hinders both the clinical management of patients and the investigation of new therapies. In order to overcome these issues, the device developed in MERLIN will for the first time enable doctors to examine the retina with multiple imaging modalities at both the macroscopic and microscopic scales. Modalities will include ultrafast scanning laser ophthalmoscopy (SLO), optical coherence tomography (OCT) and OCT angiography (OCT-A), while ultrahigh resolution will be provided by adaptive optics technology. This unique combination will reveal previously invisible cellular and microvascular retinal detail in 3 dimensions. The project partners will also develop advanced image processing software for the visualization and quantitative analysis of microscopic structures, and conduct experimentations to optimize and validate performance in AMD and DR patients. As the feasibility of this diagnostic approach has previously been demonstrated in another European R&D project (FP7 FAMOS, 2012-2017), MERLIN will translate the technology from a preexisting laboratory prototype to a nearly commercial device usable in clinical trials.


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 Deliverables

List of deliverables.
Linkedin, facebook and twitter accounts created Websites, patent fillings, videos etc. 2020-04-14 17:05:56

Take a look to the deliverables list in detail:  detailed list of MERLIN deliverables.

 Publications

year authors and title journal last update
List of publications.
2019 Luisa Sánchez Brea, Danilo Andrade De Jesus, Muhammad Faizan Shirazi, Michael Pircher, Theo van Walsum, Stefan Klein
Review on Retrospective Procedures to Correct Retinal Motion Artefacts in OCT Imaging
published pages: 2700, ISSN: 2076-3417, DOI: 10.3390/app9132700
Applied Sciences 9/13 2020-04-14
2018 Matthias Salas, Marco Augustin, Franz Felberer, Andreas Wartak, Marie Laslandes, Laurin Ginner, Michael Niederleithner, Jason Ensher, Michael P. Minneman, Rainer A. Leitgeb, Wolfgang Drexler, Xavier Levecq, Ursula Schmidt-Erfurth, Michael Pircher
Compact akinetic swept source optical coherence tomography angiography at 1060 nm supporting a wide field of view and adaptive optics imaging modes of the posterior eye
published pages: 1871, ISSN: 2156-7085, DOI: 10.1364/BOE.9.001871
Biomedical Optics Express 9/4 2020-04-14

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The information about "MERLIN" are provided by the European Opendata Portal: CORDIS opendata.

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