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MERLIN SIGNED

Multi-modal, multi-scale retinal imaging

Total Cost €

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EC-Contrib. €

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Partnership

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Outcomes and
results

MERLIN project word cloud

Explore the words cloud of the MERLIN project. It provides you a very rough idea of what is the project "MERLIN" about.

therapies conduct slo investigation retina oct first chronic microvascular laser merlin reveal modalities quantitative blindness demonstrated fp7 cellular diagnosis follow alterations coherence tomography commercial people angiography preexisting 55 medical ultrafast stage worldwide nearly 2017 2012 multiple ambition pathological invisible dr specificity limitations clinical translate structures optical doctors performance retinopathy resolution diabetic dimensions visualization diabetes device optics hinders enhanced scales degeneration optimize validate amd eye trials detect scanning ophthalmoscopy adaptive experimentations treatments time difficult software imaging combination usable retinal therapeutic laboratory techniques months macular age diagnostic feasibility microscopic sensitivity overcome pathologies macroscopic prototype famos image previously ultrahigh patients slowly takes diseases vascular examine

Project "MERLIN" data sheet

The following table provides information about the project.

Coordinator	IMAGINE EYES SA Organization address address: RUE CHARLES DE GAULLE 18 city: ORSAY postcode: 91400 website: www.imagine-eyes.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	France [FR]
Project website	https://www.imagine-eyes.com/merlin/
Total cost	5˙678˙335 €
EC max contribution	4˙867˙660 € (86%)
Programme	1. H2020-EU.2.1.1. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Information and Communication Technologies (ICT))
Code Call	H2020-ICT-2017-1
Funding Scheme	IA
Starting year	2017
Duration (year-month-day)	from 2017-12-01 to 2020-11-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	IMAGINE EYES SA IMAGINE EYES SA Organization address address: RUE CHARLES DE GAULLE 18 city: ORSAY postcode: 91400 website: www.imagine-eyes.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (ORSAY)	coordinator	1˙891˙575.00
2	ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM Organization address address: DR MOLEWATERPLEIN 40 city: ROTTERDAM postcode: 3015 GD website: www.erasmusmc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (ROTTERDAM)	participant	1˙072˙825.00
3	MEDIZINISCHE UNIVERSITAET WIEN MEDIZINISCHE UNIVERSITAET WIEN Organization address address: SPITALGASSE 23 city: WIEN postcode: 1090 website: www.meduniwien.ac.at contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (WIEN)	participant	588˙025.00
4	FUNDACIO INSTITUT DE CIENCIES FOTONIQUES FUNDACIO INSTITUT DE CIENCIES FOTONIQUES Organization address address: AVINGUDA CARL FRIEDRICH GAUSS 3 city: Castelldefels postcode: 8860 website: www.icfo.eu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (Castelldefels)	participant	522˙500.00
5	INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Organization address address: RUE DE TOLBIAC 101 city: PARIS postcode: 75654 website: www.inserm.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	431˙000.00
6	REGION HOVEDSTADEN REGION HOVEDSTADEN Organization address address: KONGENS VAENGE 2 city: HILLEROD postcode: 3400 website: www.regionh.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (HILLEROD)	participant	361˙735.00

Map

Project objective

The ambition of the MERLIN project is to improve in-depth diagnosis and therapeutic follow-up of diseases that impact the eye’s retina. To do so, the MERLIN partners will deliver a novel medical imaging device able to detect pathological alterations in the retina with highly enhanced sensitivity and specificity. The medical applications of this device encompass a wide range of retinal pathologies, including age-related macular degeneration (AMD), as well as chronic vascular conditions, including diabetes. AMD and diabetic retinopathy (DR) are the leading cause of blindness worldwide in people over 55 years of age. Such diseases slowly develop at the microscopic scale in the retina. Using current imaging techniques, it is difficult to detect them at early stage, and it often takes months to assess the effects of treatments. These limitations hinders both the clinical management of patients and the investigation of new therapies. In order to overcome these issues, the device developed in MERLIN will for the first time enable doctors to examine the retina with multiple imaging modalities at both the macroscopic and microscopic scales. Modalities will include ultrafast scanning laser ophthalmoscopy (SLO), optical coherence tomography (OCT) and OCT angiography (OCT-A), while ultrahigh resolution will be provided by adaptive optics technology. This unique combination will reveal previously invisible cellular and microvascular retinal detail in 3 dimensions. The project partners will also develop advanced image processing software for the visualization and quantitative analysis of microscopic structures, and conduct experimentations to optimize and validate performance in AMD and DR patients. As the feasibility of this diagnostic approach has previously been demonstrated in another European R&D project (FP7 FAMOS, 2012-2017), MERLIN will translate the technology from a preexisting laboratory prototype to a nearly commercial device usable in clinical trials.

Deliverables

List of deliverables.
Linkedin, facebook and twitter accounts created	Websites, patent fillings, videos etc.	2020-04-14 17:05:56

Take a look to the deliverables list in detail: detailed list of MERLIN deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2019	Luisa SÃ¡nchez Brea, Danilo Andrade De Jesus, Muhammad Faizan Shirazi, Michael Pircher, Theo van Walsum, Stefan Klein Review on Retrospective Procedures to Correct Retinal Motion Artefacts in OCT Imaging published pages: 2700, ISSN: 2076-3417, DOI: 10.3390/app9132700	Applied Sciences 9/13	2020-04-14
2018	Matthias Salas, Marco Augustin, Franz Felberer, Andreas Wartak, Marie Laslandes, Laurin Ginner, Michael Niederleithner, Jason Ensher, Michael P. Minneman, Rainer A. Leitgeb, Wolfgang Drexler, Xavier Levecq, Ursula Schmidt-Erfurth, Michael Pircher Compact akinetic swept source optical coherence tomography angiography at 1060 nm supporting a wide field of view and adaptive optics imaging modes of the posterior eye published pages: 1871, ISSN: 2156-7085, DOI: 10.1364/BOE.9.001871	Biomedical Optics Express 9/4	2020-04-14

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The information about "MERLIN" are provided by the European Opendata Portal: CORDIS opendata.

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