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MRS in diabetes SIGNED

Novel methods in Magnetic Resonance Spectroscopy to investigate mechanisms underlying metabolic disease

Total Cost €

0

EC-Contrib. €

0

Partnership

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 MRS in diabetes project word cloud

Explore the words cloud of the MRS in diabetes project. It provides you a very rough idea of what is the project "MRS in diabetes" about.

data    sectional    modified    animal    resonance    quantify    humans    gained    therapeutic    metabolite    capacity    pilot    resistance    physiological    carnitine    protocol    diseases    showed    spectroscopy    rodent    health    human    acetylcarnitine    translational    interventional    thereby    urgently    flexibility    hypothesize    reliably    hampered    hypothesis    disease    sensitivity    explored    diabetes    muscle    protein    cross    acetylation    cell    strategy    methodology    validation    central    interventions    techniques    ectopic    obesity    act    associate    insulin    free    quantified    pathogenesis    nad    regulator    mechanistic    mrs    determinant    skeletal    metabolic    detect    that    metabolites    invasive    cardiovascular    experiments    form    allowed    careful    vivo    me    identification    sequences    magnetic    concentrations    prevalence    levels    succesfully    earlier    synergistically    relevance    original    lipids    supplementation   

Project "MRS in diabetes" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITEIT MAASTRICHT 

Organization address
address: Minderbroedersberg 4-6
city: MAASTRICHT
postcode: 6200 MD
website: http://www.maastrichtuniversity.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-03-01   to  2023-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITEIT MAASTRICHT NL (MAASTRICHT) coordinator 1˙500˙000.00

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 Project objective

The high prevalence of obesity-related metabolic disease such as diabetes and cardiovascular disease urgently requires earlier interventions in the pathogenesis of these diseases and the identification of new therapeutic targets that work in humans. To show the human relevance of mechanistic information gained from rodent and cell studies on the pathogenesis of insulin resistance and diabetes, human translational research is needed. Non-invasive techniques are key in human translational research. Magnetic Resonance Spectroscopy (MRS) is used in metabolic research, e.g. to determine ectopic lipids, but its potential is far from fully explored, and novel, dedicated MRS sequences can be developed to target new metabolites in vivo. As an example, I recently showed that the metabolite acetylcarnitine can be quantified by a modified MRS protocol, which allowed me to demonstrate in humans that acetylcarnitine concentrations in muscle strongly associate with insulin sensitivity. Furthermore, it lead to pilot data that show that the capacity to form acetylcarnitine can be hampered by low carnitine availability and that this is a determinant of metabolic flexibility, which can be succesfully targeted by carnitine supplementation. In the current proposal I aim to develop novel MRS methodology to detect levels of NAD, another metabolite that is emerging from animal research as a central regulator of metabolic health. I will develop a non-invasive method to reliably quantify NAD in skeletal muscle by MRS. After careful validation of the method, I will determine the physiological relevance in a human cross-sectional study. I hypothesize that NAD and formation of acetylcarnitine act synergistically in determining protein acetylation and thereby affect metabolic flexibility. I will test this original hypothesis by increasing NAD and free carnitine using human interventional experiments and will investigate if this is a novel strategy to improve metabolic health.

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The information about "MRS IN DIABETES" are provided by the European Opendata Portal: CORDIS opendata.

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