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MRS in diabetes SIGNED

Novel methods in Magnetic Resonance Spectroscopy to investigate mechanisms underlying metabolic disease

Total Cost €

0

EC-Contrib. €

0

Partnership

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 MRS in diabetes project word cloud

Explore the words cloud of the MRS in diabetes project. It provides you a very rough idea of what is the project "MRS in diabetes" about.

techniques    succesfully    reliably    cardiovascular    levels    prevalence    metabolic    magnetic    associate    form    identification    interventions    spectroscopy    animal    health    carnitine    methodology    mechanistic    resistance    protocol    metabolites    pathogenesis    cross    diabetes    sectional    hypothesis    explored    experiments    nad    acetylation    concentrations    metabolite    strategy    disease    cell    flexibility    that    original    central    gained    relevance    sensitivity    validation    quantify    quantified    vivo    hampered    invasive    showed    hypothesize    determinant    thereby    synergistically    therapeutic    sequences    me    careful    mrs    data    interventional    detect    insulin    human    ectopic    obesity    act    acetylcarnitine    skeletal    capacity    allowed    regulator    resonance    free    translational    urgently    humans    lipids    modified    rodent    protein    diseases    pilot    supplementation    physiological    earlier    muscle   

Project "MRS in diabetes" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITEIT MAASTRICHT 

Organization address
address: Minderbroedersberg 4-6
city: MAASTRICHT
postcode: 6200 MD
website: http://www.maastrichtuniversity.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-03-01   to  2023-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITEIT MAASTRICHT NL (MAASTRICHT) coordinator 1˙500˙000.00

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 Project objective

The high prevalence of obesity-related metabolic disease such as diabetes and cardiovascular disease urgently requires earlier interventions in the pathogenesis of these diseases and the identification of new therapeutic targets that work in humans. To show the human relevance of mechanistic information gained from rodent and cell studies on the pathogenesis of insulin resistance and diabetes, human translational research is needed. Non-invasive techniques are key in human translational research. Magnetic Resonance Spectroscopy (MRS) is used in metabolic research, e.g. to determine ectopic lipids, but its potential is far from fully explored, and novel, dedicated MRS sequences can be developed to target new metabolites in vivo. As an example, I recently showed that the metabolite acetylcarnitine can be quantified by a modified MRS protocol, which allowed me to demonstrate in humans that acetylcarnitine concentrations in muscle strongly associate with insulin sensitivity. Furthermore, it lead to pilot data that show that the capacity to form acetylcarnitine can be hampered by low carnitine availability and that this is a determinant of metabolic flexibility, which can be succesfully targeted by carnitine supplementation. In the current proposal I aim to develop novel MRS methodology to detect levels of NAD, another metabolite that is emerging from animal research as a central regulator of metabolic health. I will develop a non-invasive method to reliably quantify NAD in skeletal muscle by MRS. After careful validation of the method, I will determine the physiological relevance in a human cross-sectional study. I hypothesize that NAD and formation of acetylcarnitine act synergistically in determining protein acetylation and thereby affect metabolic flexibility. I will test this original hypothesis by increasing NAD and free carnitine using human interventional experiments and will investigate if this is a novel strategy to improve metabolic health.

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The information about "MRS IN DIABETES" are provided by the European Opendata Portal: CORDIS opendata.

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