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High-temperature Thermophoresis using advanced optical microscopies

Total Cost €


EC-Contrib. €






 HiPhore project word cloud

Explore the words cloud of the HiPhore project. It provides you a very rough idea of what is the project "HiPhore" about.

aroused    small    sciences    consisting    invasive    microscopy    113    microorganisms    water    thermophoresis    solutes    origin    colloids    quantitatively    explore    regime    coin    breakthroughs    hiphore    living    microscale    glance    time    trap    protein    multiple    spatial    temperature    dissolved    observation    mtl    heat    decade    shape    wish    thanks    reducing    gradients    active    liquids    created    hyperthermophilic    scales    profiles    stability    life    last    shown    liquid    thermal    gold    concentration    sub    nanosources    first    illumination    free    gain    quantitative    species    culture    pioneer    enigmatic    tools    fluids    motion    denotes    super    proteins    possibility    superthermophoretic    resonance    dna    vivo    nanoparticles    optical    image    superheated    faster    arbitrarily    bioanalytics    deg    metastable    parallel    200    pressure    consists    ing    micro    context    plasmonic    molecular    ambient    label   

Project "HiPhore" data sheet

The following table provides information about the project.


Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙922˙973 €
 EC max contribution 1˙922˙973 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-COG
 Funding Scheme ERC-COG
 Starting year 2018
 Duration (year-month-day) from 2018-03-01   to  2023-02-28


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Thermophoresis denotes the motion of dissolved species in fluids created by temperature gradients. In water, the origin of thermophoresis is multiple, complex and still a matter of active research activities for solutes such as proteins, DNA or colloids.

Thermophoresis at small scales (sub-100 µm) aroused a strong interest this last decade because it makes the process faster and because of the development of important applications in life sciences, e.g. in bioanalytics. However, reducing the spatial scale makes quantitative and non-invasive measurements of temperature and molecular concentration more challenging.

In the HiPhore project, using gold nanoparticles under illumination as nanosources of heat, I wish to achieve major breakthroughs in the field of microscale thermophoresis in liquids (MTL): (i) We will develop new microscopy tools and pioneer their use in the context of MTL: we will implement the possibility to shape arbitrarily complex microscale temperature profiles and to quantitatively image in parallel the resulting fields of temperature and molecular concentration using label-free advanced optical tools. (ii) Thanks to these tools, we will study the enigmatic origin of protein thermophoresis with a new glance. We will also explore a new regime, that I coin super-thermophoresis, consisting in thermophoresis in superheated liquid water up to 200°C. We have shown that such a metastable state can be achieved at ambient pressure using gold nanoparticles under illumination at their plasmonic resonance. (iii) Based on this gain of knowledge and know-how, we will develop two new applications of MTL. The first one consists in studying the thermal stability of proteins by thermophoresis with a label-free approach. The second one consists in using a superthermophoretic trap to enable for the first time the culture and the real-time observation of hyperthermophilic microorganisms (living up to 113°C) in vivo at ambient pressure under optical microscopy means.


year authors and title journal last update
List of publications.
2019 Ljiljana Durdevic, Hadrien M. L. Robert, Benoit Wattellier, Serge Monneret, Guillaume Baffou
Microscale Temperature Shaping Using Spatial Light Modulation on Gold Nanoparticles
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-40382-3
Scientific Reports 9/1 2019-10-29

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