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GlycoSkin SIGNED

Dissection of Glycan Function by Engineered Tissue Models

Total Cost €

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EC-Contrib. €

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Partnership

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 GlycoSkin project word cloud

Explore the words cloud of the GlycoSkin project. It provides you a very rough idea of what is the project "GlycoSkin" about.

building    specificity    membranes    acids    life    complexity    sophisticated    normal    glycomics    dissection    combination    glycan    interaction    first    organisms    few    protein    broad    half    amino    decipher    difficulties    glycome    barriers    induce    host    technologies    severely    interactions    century    feasible    oncogenic    functions    structure    regulation    organotypic    lipids    cells    point    fewer    simplify    entry    molecularly    viral    microbiome    glycosylation    huge    blocks    genetic    nucleic    mass    transformation    capacities    pathogen    group    models    shape    homeostasis    proteins    step    influence    analyzing    pioneered    herpes    cancer    virus    glycans    underlie    limited    emergence    structural    biological    dissected    difficult    aberrant    tissue    discovery    genes    propagation    cell    model    generation    gene    cover    species    driving    editing    function    spectrometry    hampered    fine    decorate    functional    diversity    relationships    deconstruction    contrast    tunes    epithelial    organism    glycogenome   

Project "GlycoSkin" data sheet

The following table provides information about the project.

Coordinator
KOBENHAVNS UNIVERSITET 

Organization address
address: NORREGADE 10
city: KOBENHAVN
postcode: 1165
website: www.ku.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Project website https://icmm.ku.dk/english/research-groups/wandall-group/glycoskin/
 Total cost 1˙995˙199 €
 EC max contribution 1˙995˙199 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-COG
 Funding Scheme ERC-COG
 Starting year 2018
 Duration (year-month-day) from 2018-03-01   to  2023-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) coordinator 1˙995˙199.00

Map

 Project objective

Glycans decorate most proteins, cover cell membranes, and represent one of the four building blocks of life, together with nucleic acids, lipids, and amino acids. Yet, our understanding of how glycans influence the life of cells and organisms is limited, and only few functions have been molecularly dissected. Glycans present a huge structural diversity with species and cell- type specificity that underlie specific biological functions. However, more than half a century of research has been severely hampered by the complexity and technical difficulties with analyzing glycans. While, the glycome (all glycans in a cell or organism) is a difficult entry point for discovery, the glycogenome (all genes involved in glycosylation) in contrast is a feasible entry point, because most of the genes controlling glycosylation are now known, and there are fewer technical barriers especially with the emergence of gene editing technologies.

Our research group has pioneered the “glycogenome entry” to functional glycomics using gene editing to simplify glycosylation in cells. My research group has pioneered a next generation approach using organotypic tissue models in combination with sophisticated mass spectrometry to decipher glycan functions. The tissue model has provided the first evidence that aberrant glycosylation in cancer directly induce oncogenic features, and that glycosylation of Herpes virus is essential for viral propagation. In this proposal, I will use step-by-step genetic deconstruction of glycosylation capacities in organotypic tissue models for broad discovery and dissection of specific structure-function relationships driving normal epithelial formation, transformation and interaction with the microbiome. Specifically, I will address:

1. How glycosylation affect and shape epithelial homeostasis and transformation 2. How regulation of glycosylation fine-tunes protein functions 3. How glycans influence host-pathogen interactions in “real” epithelial tissue models

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The information about "GLYCOSKIN" are provided by the European Opendata Portal: CORDIS opendata.

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