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GlycoSkin SIGNED

Dissection of Glycan Function by Engineered Tissue Models

Total Cost €

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EC-Contrib. €

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Partnership

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 GlycoSkin project word cloud

Explore the words cloud of the GlycoSkin project. It provides you a very rough idea of what is the project "GlycoSkin" about.

entry    building    structure    cancer    functions    discovery    virus    organisms    emergence    induce    fewer    homeostasis    normal    severely    analyzing    mass    driving    biological    tunes    glycome    protein    capacities    contrast    glycosylation    decipher    glycogenome    step    acids    few    epithelial    transformation    amino    generation    point    sophisticated    glycomics    organism    host    century    molecularly    cell    diversity    technologies    blocks    organotypic    spectrometry    cover    specificity    combination    barriers    relationships    broad    interactions    pathogen    simplify    species    nucleic    tissue    lipids    models    genes    fine    membranes    difficult    viral    propagation    proteins    functional    decorate    genetic    model    glycans    underlie    feasible    difficulties    hampered    shape    structural    huge    dissected    microbiome    life    group    cells    complexity    gene    first    herpes    editing    half    aberrant    influence    deconstruction    regulation    limited    dissection    oncogenic    pioneered    glycan    function    interaction   

Project "GlycoSkin" data sheet

The following table provides information about the project.

Coordinator
KOBENHAVNS UNIVERSITET 

Organization address
address: NORREGADE 10
city: KOBENHAVN
postcode: 1165
website: www.ku.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Project website https://icmm.ku.dk/english/research-groups/wandall-group/glycoskin/
 Total cost 1˙995˙199 €
 EC max contribution 1˙995˙199 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-COG
 Funding Scheme ERC-COG
 Starting year 2018
 Duration (year-month-day) from 2018-03-01   to  2023-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) coordinator 1˙995˙199.00

Map

 Project objective

Glycans decorate most proteins, cover cell membranes, and represent one of the four building blocks of life, together with nucleic acids, lipids, and amino acids. Yet, our understanding of how glycans influence the life of cells and organisms is limited, and only few functions have been molecularly dissected. Glycans present a huge structural diversity with species and cell- type specificity that underlie specific biological functions. However, more than half a century of research has been severely hampered by the complexity and technical difficulties with analyzing glycans. While, the glycome (all glycans in a cell or organism) is a difficult entry point for discovery, the glycogenome (all genes involved in glycosylation) in contrast is a feasible entry point, because most of the genes controlling glycosylation are now known, and there are fewer technical barriers especially with the emergence of gene editing technologies.

Our research group has pioneered the “glycogenome entry” to functional glycomics using gene editing to simplify glycosylation in cells. My research group has pioneered a next generation approach using organotypic tissue models in combination with sophisticated mass spectrometry to decipher glycan functions. The tissue model has provided the first evidence that aberrant glycosylation in cancer directly induce oncogenic features, and that glycosylation of Herpes virus is essential for viral propagation. In this proposal, I will use step-by-step genetic deconstruction of glycosylation capacities in organotypic tissue models for broad discovery and dissection of specific structure-function relationships driving normal epithelial formation, transformation and interaction with the microbiome. Specifically, I will address:

1. How glycosylation affect and shape epithelial homeostasis and transformation 2. How regulation of glycosylation fine-tunes protein functions 3. How glycans influence host-pathogen interactions in “real” epithelial tissue models

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The information about "GLYCOSKIN" are provided by the European Opendata Portal: CORDIS opendata.

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