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GlycoSkin SIGNED

Dissection of Glycan Function by Engineered Tissue Models

Total Cost €

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EC-Contrib. €

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Partnership

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 GlycoSkin project word cloud

Explore the words cloud of the GlycoSkin project. It provides you a very rough idea of what is the project "GlycoSkin" about.

limited    tissue    glycosylation    proteins    normal    acids    virus    specificity    models    structural    entry    organotypic    organism    cells    shape    microbiome    biological    cell    membranes    huge    functional    hampered    combination    host    step    glycan    amino    spectrometry    tunes    diversity    nucleic    few    gene    difficulties    generation    induce    emergence    herpes    difficult    structure    simplify    point    century    building    decorate    fewer    decipher    underlie    lipids    glycomics    pathogen    life    molecularly    barriers    contrast    technologies    discovery    half    genes    propagation    broad    relationships    interaction    oncogenic    interactions    cancer    complexity    capacities    functions    aberrant    first    transformation    pioneered    mass    glycogenome    severely    viral    cover    function    influence    blocks    dissection    species    feasible    group    sophisticated    homeostasis    epithelial    regulation    protein    model    editing    glycome    fine    genetic    analyzing    deconstruction    glycans    driving    dissected    organisms   

Project "GlycoSkin" data sheet

The following table provides information about the project.

Coordinator
KOBENHAVNS UNIVERSITET 

Organization address
address: NORREGADE 10
city: KOBENHAVN
postcode: 1165
website: www.ku.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Project website https://icmm.ku.dk/english/research-groups/wandall-group/glycoskin/
 Total cost 1˙995˙199 €
 EC max contribution 1˙995˙199 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-COG
 Funding Scheme ERC-COG
 Starting year 2018
 Duration (year-month-day) from 2018-03-01   to  2023-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) coordinator 1˙995˙199.00

Map

 Project objective

Glycans decorate most proteins, cover cell membranes, and represent one of the four building blocks of life, together with nucleic acids, lipids, and amino acids. Yet, our understanding of how glycans influence the life of cells and organisms is limited, and only few functions have been molecularly dissected. Glycans present a huge structural diversity with species and cell- type specificity that underlie specific biological functions. However, more than half a century of research has been severely hampered by the complexity and technical difficulties with analyzing glycans. While, the glycome (all glycans in a cell or organism) is a difficult entry point for discovery, the glycogenome (all genes involved in glycosylation) in contrast is a feasible entry point, because most of the genes controlling glycosylation are now known, and there are fewer technical barriers especially with the emergence of gene editing technologies.

Our research group has pioneered the “glycogenome entry” to functional glycomics using gene editing to simplify glycosylation in cells. My research group has pioneered a next generation approach using organotypic tissue models in combination with sophisticated mass spectrometry to decipher glycan functions. The tissue model has provided the first evidence that aberrant glycosylation in cancer directly induce oncogenic features, and that glycosylation of Herpes virus is essential for viral propagation. In this proposal, I will use step-by-step genetic deconstruction of glycosylation capacities in organotypic tissue models for broad discovery and dissection of specific structure-function relationships driving normal epithelial formation, transformation and interaction with the microbiome. Specifically, I will address:

1. How glycosylation affect and shape epithelial homeostasis and transformation 2. How regulation of glycosylation fine-tunes protein functions 3. How glycans influence host-pathogen interactions in “real” epithelial tissue models

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The information about "GLYCOSKIN" are provided by the European Opendata Portal: CORDIS opendata.

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