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ExoSonic SIGNED

A microfluidic chip for non-invasive, early detection of pancreatic cancer – liquid biopsy

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 ExoSonic project word cloud

Explore the words cloud of the ExoSonic project. It provides you a very rough idea of what is the project "ExoSonic" about.

edge    mortality    specificity    plan    resource    screening    sentence    predicted    window    clinical    therapies    inability    pancreatic    hospital    shed    era    isolated    tumour    biomarkers    resolution    sensitivity    sized    nanometre    detecting    technically    changed    precision    emerged    particles    constraints    ultralow    vesicles    laboratories    elapses    extremely    opportunity    inefficient    disease    harness    invasive    paving    inaccessible    poor    survival    diagnosis    module    chamber    microfluidic    diagnostics    isolation    commercialisation    uk    fabrication    circulating    first    microfabrication    rate    blood       leverages    death    stage    chip    bloodstream    patient    detection    lack    utilisation    suggesting    cutting    beginning    2030    initial    cancer    technological    components    exosome    powerful    possessing    unprecedented    incorporate    facilities    exosomes    tiny    figure    separation    settings    detect    fourth    decades    device    concerned    regarded    biomarker   

Project "ExoSonic" data sheet

The following table provides information about the project.

Coordinator
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE 

Organization address
address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD
city: LONDON
postcode: SW7 2AZ
website: http://www.imperial.ac.uk/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 149˙997 €
 EC max contribution 149˙996 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-PoC
 Funding Scheme ERC-POC
 Starting year 2018
 Duration (year-month-day) from 2018-02-01   to  2019-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE UK (LONDON) coordinator 149˙996.00

Map

 Project objective

Pancreatic cancer is the fourth-leading cause of cancer related mortality and is predicted to be the second leading cause of cancer death by 2030. Widely regarded as a death sentence, the 5-year survival rate is only 3% in the UK and this figure has not changed over the past four decades due to lack of specific therapies and inability to detect it early. Several years often elapses from the beginning of the disease to the patient’s diagnosis, suggesting a window of opportunity for early detection. Recently, tiny nanometre-sized vesicles (exosomes) shed by the tumour in the bloodstream, have emerged as powerful circulating biomarkers possessing extremely high sensitivity and specificity, thus paving the way for a new era of non-invasive cancer diagnostics. However, currently the process of exosome isolation and detection is not only highly inefficient, but also technically challenging and inaccessible to hospital laboratories, clinical facilities and resource-poor settings. To address technological constraints of exosome utilisation, we are developing a microfluidic device that leverages cutting-edge microfabrication technology to enable isolation and detection of tumour exosomes from the blood for screening and detecting early-stage pancreatic cancer with unprecedented precision. This chip will have two components, a separation module where exosomes will be isolated from all other blood particles, and a detection chamber that will incorporate technology to achieve ultralow resolution. The first stage of development will be concerned with the fabrication of all components necessary to harness the sensitivity of the exosome biomarker. Following initial testing, we plan to take steps towards commercialisation of the device.

 Publications

year authors and title journal last update
List of publications.
2019 Alistair Rice, Armando del Rio Hernandez
The mutational landscape of pancreatic and liver cancers, as represented by circulating tumour DNA
published pages: , ISSN: 2234-943X, DOI: 10.3389/fonc.2019.00952
Frontiers in Oncology 2020-03-30
2018 Carlos Matellan, Armando E. del Río Hernández
Cost-effective rapid prototyping and assembly of poly(methyl methacrylate) microfluidic devices
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-25202-4
Scientific Reports 8/1 2020-03-30
2018 Tyler Lieberthal
Bioengineering and biomechanical approaches for pancreatic cancer
published pages: , ISSN: , DOI:
2020-03-30
2019 Deana Kwong Hong Tsang, Tyler Lieberthal, Clare Watts. Iain E. Dunlop, Sami Ramadan, Armando Del Rio Hernandez, Norbert Klein
Chemically Functionalised Graphene FET Biosensor for the Label-free Sensing of Exosomes
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-50412-9
Scientific Reports 2020-03-30

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