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Unraveling the Molecular Changes that Drive the Repression of the Unfolded Protein Response with Ageing

Total Cost €


EC-Contrib. €






 UCUPA project word cloud

Explore the words cloud of the UCUPA project. It provides you a very rough idea of what is the project "UCUPA" about.

signalling    instrumental    shutdown    transgenic    dysfunction    central    assays    mutagenesis    therapeutic    quality    skills    mechanism    molecular    sensor    implicated    elegans    biological    er    strains    occurs    specialized    transmembrane    lose    function    biogenesis    age    monitoring    independence    organelles    cell    models    disease    prevent    folding    weeks    proteins    xbp    proteostasis    upr    1s    activation    nematode    specialization    disorders    screening    biology    functional    evolution    vertebrate    crispr    ethical    defines    advantages    folded    transcription    ageing    translated    declines    arisen    alzheimer    endoplasmic    accumulation    track    properly    genome    animals    techniques    ire    avenues    understand    monitor    protein    model    what    me    lifespan    reticulum    onset    screen    unfolded    suggesting    transference    caenorhabditis    molecules    reporter    itself    microscopy    protect    host    aggregates    editing    interventions    create    proteome    fewer   

Project "UCUPA" data sheet

The following table provides information about the project.


Organization address
postcode: SN2 1FL
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 212˙933 €
 EC max contribution 212˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-08-01   to  2022-07-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

What defines the functional specialization of a cell is its unique proteome. Proteins need to be translated and properly folded to ensure their biological function. Several protein quality control pathways have arisen during evolution, some of them specialized in monitoring protein folding in specific organelles . As a result of ageing, animals lose their ability to protect their proteome, leading to the accumulation of protein aggregates and the onset of age-related disorders. The Unfolded Protein Response (UPR) of the Endoplasmic Reticulum (ER) is a central protein quality control mechanism that declines with ageing. This project will use the nematode Caenorhabditis elegans as a model to understand age-related proteostasis dysfunction. C. elegans offer many advantages over the use of vertebrate models, such as its short lifespan of about two weeks, reduced costs, and fewer ethical issues. We will focus on the UPR pathway, as changes in this pathway have already been implicated in the ageing process itself and in the onset of age-related disorders, such as Alzheimer’s disease. We propose to use CRISPR genome editing to create C. elegans transgenic reporter strains that enable us to track the activity of different UPR signalling molecules using microscopy and molecular biology techniques. We will monitor two central steps of the IRE-1/XBP-1 UPR pathway (1) the activation of the transmembrane sensor protein IRE-1 and (2) the biogenesis of the transcription factor XBP-1s. After age-related changes have been identified, we will use mutagenesis-based screening assays to screen for novel interventions that prevent UPR pathway shutdown. This research will contribute to a better understanding of why ageing occurs, as well as suggesting new therapeutic avenues for age-related disorders. This proposal will also be instrumental for the development and transference of new skills between the host and the applicant that will lead me towards independence.

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The information about "UCUPA" are provided by the European Opendata Portal: CORDIS opendata.

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