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UCUPA SIGNED

Unraveling the Molecular Changes that Drive the Repression of the Unfolded Protein Response with Ageing

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 UCUPA project word cloud

Explore the words cloud of the UCUPA project. It provides you a very rough idea of what is the project "UCUPA" about.

avenues    track    transgenic    weeks    lose    folded    disease    biology    vertebrate    crispr    proteostasis    specialization    models    elegans    monitoring    er    specialized    translated    sensor    animals    dysfunction    nematode    caenorhabditis    protein    molecular    monitor    itself    suggesting    declines    editing    evolution    understand    onset    genome    transmembrane    ethical    implicated    screen    age    molecules    ire    mutagenesis    functional    fewer    biological    defines    lifespan    mechanism    aggregates    activation    screening    upr    alzheimer    instrumental    microscopy    reticulum    organelles    biogenesis    unfolded    assays    protect    model    central    independence    me    skills    transcription    proteins    disorders    proteome    techniques    strains    1s    accumulation    arisen    what    therapeutic    function    endoplasmic    advantages    shutdown    create    quality    reporter    occurs    properly    ageing    transference    signalling    host    folding    interventions    prevent    xbp    cell   

Project "UCUPA" data sheet

The following table provides information about the project.

Coordinator
UNITED KINGDOM RESEARCH AND INNOVATION 

Organization address
address: POLARIS HOUSE NORTH STAR AVENUE
city: SWINDON
postcode: SN2 1FL
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 212˙933 €
 EC max contribution 212˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-08-01   to  2022-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNITED KINGDOM RESEARCH AND INNOVATION UK (SWINDON) coordinator 212˙933.00

Map

 Project objective

What defines the functional specialization of a cell is its unique proteome. Proteins need to be translated and properly folded to ensure their biological function. Several protein quality control pathways have arisen during evolution, some of them specialized in monitoring protein folding in specific organelles . As a result of ageing, animals lose their ability to protect their proteome, leading to the accumulation of protein aggregates and the onset of age-related disorders. The Unfolded Protein Response (UPR) of the Endoplasmic Reticulum (ER) is a central protein quality control mechanism that declines with ageing. This project will use the nematode Caenorhabditis elegans as a model to understand age-related proteostasis dysfunction. C. elegans offer many advantages over the use of vertebrate models, such as its short lifespan of about two weeks, reduced costs, and fewer ethical issues. We will focus on the UPR pathway, as changes in this pathway have already been implicated in the ageing process itself and in the onset of age-related disorders, such as Alzheimer’s disease. We propose to use CRISPR genome editing to create C. elegans transgenic reporter strains that enable us to track the activity of different UPR signalling molecules using microscopy and molecular biology techniques. We will monitor two central steps of the IRE-1/XBP-1 UPR pathway (1) the activation of the transmembrane sensor protein IRE-1 and (2) the biogenesis of the transcription factor XBP-1s. After age-related changes have been identified, we will use mutagenesis-based screening assays to screen for novel interventions that prevent UPR pathway shutdown. This research will contribute to a better understanding of why ageing occurs, as well as suggesting new therapeutic avenues for age-related disorders. This proposal will also be instrumental for the development and transference of new skills between the host and the applicant that will lead me towards independence.

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The information about "UCUPA" are provided by the European Opendata Portal: CORDIS opendata.

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