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UCUPA SIGNED

Unraveling the Molecular Changes that Drive the Repression of the Unfolded Protein Response with Ageing

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 UCUPA project word cloud

Explore the words cloud of the UCUPA project. It provides you a very rough idea of what is the project "UCUPA" about.

caenorhabditis    transcription    avenues    central    screen    biogenesis    organelles    instrumental    defines    assays    genome    monitoring    signalling    model    proteostasis    transmembrane    shutdown    interventions    dysfunction    biological    protect    suggesting    disease    host    onset    lifespan    mechanism    functional    reporter    age    er    implicated    ageing    what    animals    advantages    specialization    protein    function    sensor    arisen    independence    cell    unfolded    occurs    ire    create    reticulum    endoplasmic    nematode    weeks    prevent    understand    transference    evolution    vertebrate    mutagenesis    ethical    1s    biology    itself    properly    track    accumulation    fewer    molecules    proteins    skills    molecular    lose    transgenic    declines    editing    techniques    alzheimer    elegans    proteome    me    therapeutic    translated    strains    disorders    quality    screening    microscopy    activation    models    crispr    monitor    specialized    folding    upr    aggregates    folded    xbp   

Project "UCUPA" data sheet

The following table provides information about the project.

Coordinator
UNITED KINGDOM RESEARCH AND INNOVATION 

Organization address
address: POLARIS HOUSE NORTH STAR AVENUE
city: SWINDON
postcode: SN2 1FL
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 212˙933 €
 EC max contribution 212˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-08-01   to  2022-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNITED KINGDOM RESEARCH AND INNOVATION UK (SWINDON) coordinator 212˙933.00

Map

 Project objective

What defines the functional specialization of a cell is its unique proteome. Proteins need to be translated and properly folded to ensure their biological function. Several protein quality control pathways have arisen during evolution, some of them specialized in monitoring protein folding in specific organelles . As a result of ageing, animals lose their ability to protect their proteome, leading to the accumulation of protein aggregates and the onset of age-related disorders. The Unfolded Protein Response (UPR) of the Endoplasmic Reticulum (ER) is a central protein quality control mechanism that declines with ageing. This project will use the nematode Caenorhabditis elegans as a model to understand age-related proteostasis dysfunction. C. elegans offer many advantages over the use of vertebrate models, such as its short lifespan of about two weeks, reduced costs, and fewer ethical issues. We will focus on the UPR pathway, as changes in this pathway have already been implicated in the ageing process itself and in the onset of age-related disorders, such as Alzheimer’s disease. We propose to use CRISPR genome editing to create C. elegans transgenic reporter strains that enable us to track the activity of different UPR signalling molecules using microscopy and molecular biology techniques. We will monitor two central steps of the IRE-1/XBP-1 UPR pathway (1) the activation of the transmembrane sensor protein IRE-1 and (2) the biogenesis of the transcription factor XBP-1s. After age-related changes have been identified, we will use mutagenesis-based screening assays to screen for novel interventions that prevent UPR pathway shutdown. This research will contribute to a better understanding of why ageing occurs, as well as suggesting new therapeutic avenues for age-related disorders. This proposal will also be instrumental for the development and transference of new skills between the host and the applicant that will lead me towards independence.

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The information about "UCUPA" are provided by the European Opendata Portal: CORDIS opendata.

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