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SYNFOS

Synthetic toolkit for fragment oriented synthesis

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 SYNFOS project word cloud

Explore the words cloud of the SYNFOS project. It provides you a very rough idea of what is the project "SYNFOS" about.

hydridised    supervisor    ligand    flatter    de    fragment    crystallography    building    interactions    space    biology    fragments    tends    bonds    heterocycles    potent    academic    secondments    inhibition    exploration    discovery    group    expertise    medical    direct    join    diamond    compounds    medicinally    protein    co    leeds    remarkable    drugs    toolbox    hits    bromodomain    lipophilic    fellow    cutting    secondly    elaboration    edge    uneven    ray    firstly    modes    leader    multidisciplinary    showcase    inhibitors    synthetic    mainstream    fellowship    interaction    elaborated    marsden    steve    carbons    sp3    atad2    yielding    chemical    molecular    despite    adam    tend    exacerbate    prospects    medicinal    strategy    university    laboratory    host    train    groups    nelson    novo    heterocyclic    functionalization    independent    synthesised    ppis    trindade    professors    facilitates    reactivity    treatment    advantageous    catalysis    throughput    fbld    toolkit    synfos    alexandre    chemistry    discover    unmet    explore   

Project "SYNFOS" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF LEEDS 

Organization address
address: WOODHOUSE LANE
city: LEEDS
postcode: LS2 9JT
website: www.leeds.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://www.asn.leeds.ac.uk/view_person
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-03-01   to  2020-02-29

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF LEEDS UK (LEEDS) coordinator 195˙454.00

Map

 Project objective

Fragment-based ligand discovery (FBLD) has become a mainstream strategy to discover new drugs to enable the treatment of conditions with unmet medical needs. Despite the remarkable rise of FBLD, significant chemical challenges remain in the field; firstly, elaborated fragments tend to be synthesised de novo when direct growth would be much more advantageous. Secondly, the currently available toolkit for fragment elaboration tends to exacerbate an uneven exploration of chemical space, yielding flatter and more lipophilic compounds.

SYNFOS will allow Alexandre Trindade (the fellow) to join the laboratory of Professors Adam Nelson (host supervisor) and Steve Marsden (host co-supervisor) at the University of Leeds (Host) and develop research expertise in fragment-based ligand discovery; catalysis to enable molecular discovery; protein-protein interaction (PPIs) inhibition; and high-throughput X-ray crystallography (via secondments to Diamond (Partner)). In doing so, the fellow will (a) enhance his prospects of becoming an independent academic group leader in Europe and (b) address the need to train researchers in key multidisciplinary areas such as medicinal chemistry and chemical biology and (c) develop cutting edge synthetic methods that facilitates the fragment-based discovery of new inhibitors for protein-protein interactions. By building in fragment hits from the Host laboratory, the fellow will establish a synthetic toolkit enabling the functionalization of C-H bonds within N-heterocycles with a wide range of medicinally-relevant groups. The fellowship will explore three main modes of reactivity to establish the functionalization of sp3-hydridised carbons with heterocyclic fragments and showcase the value of the synthetic toolbox through the discovery of fragments hits into potent inhibitors of PPIs involving the ATAD2 bromodomain.

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The information about "SYNFOS" are provided by the European Opendata Portal: CORDIS opendata.

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