Opendata, web and dolomites

NovoFold SIGNED

De novo protein discovery as a tool for understanding the folding conundrum

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 NovoFold project word cloud

Explore the words cloud of the NovoFold project. It provides you a very rough idea of what is the project "NovoFold" about.

proteins    impressive    form    precision    fundamental    ultrahigh    broad    isolate    iuml    structural    na    industry    amino    insights    newly    fellowship    bioinformatic    function    ordered    gaining    experimental    quantifiable    versa    conundrum    molecular    mrna    de    paradigm    quality    intricate    cutting    analysed    macromolecules    frequency    physical    edge    techniques    patterns    functions    order    efforts    derive    libraries    1e13    space    acids    primary    generation    experimentally    utmost    biophysical    ve    essence    unparalleled    platform    modern    structure    biotechnological    size    data    point    solving    statistical    empirical    vice    sequence    performed    relates    architectures    protein    scientists    display    unprecedented    displaying    novo    discovered    bio    discovery    folded    members    polypeptides    3d    technological    exploratory    rules    biology    basis    throughput    characterisation    prerequisite    folding    engineering    training   

Project "NovoFold" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF BRISTOL 

Organization address
address: BEACON HOUSE QUEENS ROAD
city: BRISTOL
postcode: BS8 1QU
website: www.bristol.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-01-03   to  2021-01-02

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF BRISTOL UK (BRISTOL) coordinator 183˙454.00

Map

 Project objective

Order is a prerequisite for activity, which is the essence of the sequence-structure-function paradigm of bio-macromolecules. Proteins are a case in point, displaying intricate architectures and impressive functions. Understanding how the primary sequence of these complex macromolecules relates to their 3D structure and vice versa is of fundamental interest and the basis for broad technological exploitation of proteins. The proposed research aims to investigate the folding space of proteins, gaining new insights that will help in solving the folding conundrum. Specifically, the frequency and sequence patterns of ordered polypeptides and their physical and structural properties will be experimentally analysed. Based on these data sets, exploratory data analysis can be performed, providing unprecedented insights into protein folding. Generation of quantifiable high quality data is thus of utmost importance for this project. One of the main objectives of this proposal is therefore the development of an ultrahigh-throughput experimental platform for discovery of de novo proteins with unparalleled precision, using state-of-the-art molecular biology methods. Based on cutting-edge mRNA display technology, I will isolate folded polypeptides from naïve libraries with up to 1E13 members in the size range of 50-100 amino acids. Modern bioinformatic analysis, modelling and biophysical characterisation will be performed to analyse the folding space of proteins and derive new empirical folding rules. Given the increasing importance of protein engineering in fundamental research and industry, the results of this study will be of interest to a wide range of scientists. The fellowship will provide training in state-of-the-art techniques such as statistical data analysis and structural biology. The results of this research project will form the basis for future efforts to exploit the biotechnological potential of newly discovered proteins.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "NOVOFOLD" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "NOVOFOLD" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

NaWaTL (2020)

Narrative, Writing, and the Teotihuacan Language: Exploring Language History Through Phylogenetics, Epigraphy and Iconography

Read More  

PNAIC (2018)

Positive and Negative Asymmetry in Intergroup Contact: Its Impact on Linguistic Forms of Communication and Physiological Responses

Read More  

STOPFIRE (2019)

Emergency Decision Support System of Offshore Platform Fires

Read More