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De novo protein discovery as a tool for understanding the folding conundrum

Total Cost €


EC-Contrib. €






 NovoFold project word cloud

Explore the words cloud of the NovoFold project. It provides you a very rough idea of what is the project "NovoFold" about.

ultrahigh    platform    structural    space    unprecedented    discovered    biotechnological    ordered    data    rules    conundrum    solving    edge    statistical    acids    3d    size    industry    modern    unparalleled    engineering    prerequisite    discovery    displaying    experimental    bio    folding    amino    empirical    relates    techniques    architectures    utmost    fundamental    biology    protein    broad    biophysical    bioinformatic    point    proteins    newly    impressive    function    efforts    derive    libraries    characterisation    1e13    paradigm    de    technological    sequence    novo    isolate    cutting    generation    basis    exploratory    polypeptides    ve    essence    quality    throughput    mrna    gaining    vice    molecular    iuml    na    display    frequency    insights    form    intricate    macromolecules    training    experimentally    fellowship    analysed    precision    folded    order    quantifiable    performed    physical    functions    members    patterns    scientists    primary    structure    versa   

Project "NovoFold" data sheet

The following table provides information about the project.


Organization address
postcode: BS8 1QU

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-01-03   to  2021-01-02


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF BRISTOL UK (BRISTOL) coordinator 183˙454.00


 Project objective

Order is a prerequisite for activity, which is the essence of the sequence-structure-function paradigm of bio-macromolecules. Proteins are a case in point, displaying intricate architectures and impressive functions. Understanding how the primary sequence of these complex macromolecules relates to their 3D structure and vice versa is of fundamental interest and the basis for broad technological exploitation of proteins. The proposed research aims to investigate the folding space of proteins, gaining new insights that will help in solving the folding conundrum. Specifically, the frequency and sequence patterns of ordered polypeptides and their physical and structural properties will be experimentally analysed. Based on these data sets, exploratory data analysis can be performed, providing unprecedented insights into protein folding. Generation of quantifiable high quality data is thus of utmost importance for this project. One of the main objectives of this proposal is therefore the development of an ultrahigh-throughput experimental platform for discovery of de novo proteins with unparalleled precision, using state-of-the-art molecular biology methods. Based on cutting-edge mRNA display technology, I will isolate folded polypeptides from naïve libraries with up to 1E13 members in the size range of 50-100 amino acids. Modern bioinformatic analysis, modelling and biophysical characterisation will be performed to analyse the folding space of proteins and derive new empirical folding rules. Given the increasing importance of protein engineering in fundamental research and industry, the results of this study will be of interest to a wide range of scientists. The fellowship will provide training in state-of-the-art techniques such as statistical data analysis and structural biology. The results of this research project will form the basis for future efforts to exploit the biotechnological potential of newly discovered proteins.

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The information about "NOVOFOLD" are provided by the European Opendata Portal: CORDIS opendata.

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