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NovoFold SIGNED

De novo protein discovery as a tool for understanding the folding conundrum

Total Cost €

0

EC-Contrib. €

0

Partnership

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 NovoFold project word cloud

Explore the words cloud of the NovoFold project. It provides you a very rough idea of what is the project "NovoFold" about.

ordered    industry    libraries    structure    protein    unparalleled    point    ve    broad    versa    characterisation    techniques    prerequisite    precision    primary    frequency    experimental    form    essence    fellowship    basis    na    quality    unprecedented    de    members    architectures    derive    solving    folding    mrna    ultrahigh    display    folded    order    isolate    throughput    iuml    empirical    novo    generation    space    newly    physical    cutting    relates    paradigm    structural    biotechnological    fundamental    data    acids    molecular    bioinformatic    impressive    insights    biology    gaining    functions    patterns    performed    conundrum    platform    quantifiable    edge    statistical    sequence    exploratory    amino    engineering    bio    rules    discovered    intricate    experimentally    technological    scientists    utmost    vice    1e13    size    displaying    efforts    training    function    discovery    biophysical    proteins    macromolecules    analysed    polypeptides    3d    modern   

Project "NovoFold" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF BRISTOL 

Organization address
address: BEACON HOUSE QUEENS ROAD
city: BRISTOL
postcode: BS8 1QU
website: www.bristol.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-01-03   to  2021-01-02

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF BRISTOL UK (BRISTOL) coordinator 183˙454.00

Map

 Project objective

Order is a prerequisite for activity, which is the essence of the sequence-structure-function paradigm of bio-macromolecules. Proteins are a case in point, displaying intricate architectures and impressive functions. Understanding how the primary sequence of these complex macromolecules relates to their 3D structure and vice versa is of fundamental interest and the basis for broad technological exploitation of proteins. The proposed research aims to investigate the folding space of proteins, gaining new insights that will help in solving the folding conundrum. Specifically, the frequency and sequence patterns of ordered polypeptides and their physical and structural properties will be experimentally analysed. Based on these data sets, exploratory data analysis can be performed, providing unprecedented insights into protein folding. Generation of quantifiable high quality data is thus of utmost importance for this project. One of the main objectives of this proposal is therefore the development of an ultrahigh-throughput experimental platform for discovery of de novo proteins with unparalleled precision, using state-of-the-art molecular biology methods. Based on cutting-edge mRNA display technology, I will isolate folded polypeptides from naïve libraries with up to 1E13 members in the size range of 50-100 amino acids. Modern bioinformatic analysis, modelling and biophysical characterisation will be performed to analyse the folding space of proteins and derive new empirical folding rules. Given the increasing importance of protein engineering in fundamental research and industry, the results of this study will be of interest to a wide range of scientists. The fellowship will provide training in state-of-the-art techniques such as statistical data analysis and structural biology. The results of this research project will form the basis for future efforts to exploit the biotechnological potential of newly discovered proteins.

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The information about "NOVOFOLD" are provided by the European Opendata Portal: CORDIS opendata.

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