Explore the words cloud of the CONSYN project. It provides you a very rough idea of what is the project "CONSYN" about.
The following table provides information about the project.
TECHNISCHE UNIVERSITAT DARMSTADT
|Coordinator Country||Germany [DE]|
|Total cost||1˙996˙579 €|
|EC max contribution||1˙996˙579 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2018-04-01 to 2023-03-31|
Take a look of project's partnership.
|1||TECHNISCHE UNIVERSITAT DARMSTADT||DE (DARMSTADT)||coordinator||1˙996˙579.00|
Synthetic biology is the bottom-up engineering of new molecular functionality inside a biological cell. Although it aims at a quantitative and compositional approach, most of today’s implementations of synthetic circuits are based on inefficient trial-and-error runs. This approach to circuit design does not scale well with circuit complexity and is against the basic paradigm of synthetic biology. This unsatisfactory state of affairs is partly due to the lack of the right computational methodology that can support the quantitative characterization of circuits and their significant context dependency, i.e., their change in behavior upon interactions with the host machinery and with other circuit elements. CONSYN will contribute computational methodology to overcome the trial-and-error approach and to ultimately turn synthetic circuit design into a rational bottom-up process that heavily relies on computational analysis before any actual biomolecular implementation is considered. In order to achieve this goal, we will work on the following agenda: (i) develop biophysical and statistical models of biomolecular contexts into which the synthetic circuit or synthetic part can be embedded in silico; (ii) devise new statistical inference methods that can deliver accurate characterization of circuits and their context dependency by making use of cutting-edge single-cell experimental data; (iii) derive new context-insensitive circuit designs through in silico sensitivity analysis and application of filtering theory; (iv) optimize protocols and measurement infrastructure using model-based experimental design yielding a better circuit and context characterization; (v) experimentally build synthetic circuits in vivo and in cell-free systems in order to validate and bring to life the above theoretical investigations. We are in the unique position to also address (v) in-house due to the experimental wetlab facilities in our group.
|Data Management Plan||Open Research Data Pilot||2019-08-07 10:53:38|
Take a look to the deliverables list in detail: detailed list of CONSYN deliverables.
|year||authors and title||journal||last update|
Hybrid master equation for jump-diffusion approximation of biomolecular reaction networks
published pages: , ISSN: 1572-9125, DOI:
|BIT Numerical Mathematics||2019-11-28|
Christian Wildner, Heinz Koeppl
Moment-Based Variational Inference for Markov Jump Processes
published pages: , ISSN: , DOI:
|Proceedings of the 36th International Conference on Machine Learning||2019-11-07|
FranÃ§ois-Xavier Lehr, Maleen Hanst, Marc Vogel, Jennifer Kremer, H. Ulrich GÃ¶ringer, Beatrix Suess, Heinz Koeppl
Cell-Free Prototyping of AND-Logic Gates Based on Heterogeneous RNA Activators
published pages: 2163-2173, ISSN: 2161-5063, DOI: 10.1021/acssynbio.9b00238
|ACS Synthetic Biology 8/9||2019-11-07|
Johannes Falk, Leo Bronstein, Maleen Hanst, Barbara Drossel, Heinz Koeppl
Context in synthetic biology: Memory effects of environments with mono-molecular reactions
published pages: 24106, ISSN: 0021-9606, DOI: 10.1063/1.5053816
|The Journal of Chemical Physics 150/2||2019-11-07|
Dominik Lindner, Michael Schmidt, Heinz Koeppl
Scalable Structure Learning of Continuous-Time Bayesian Networks from Incomplete Data
published pages: , ISSN: , DOI:
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "CONSYN" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (email@example.com) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "CONSYN" are provided by the European Opendata Portal: CORDIS opendata.