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TRECEPTORS SIGNED

Transport and Receptor Mechanisms of Human Solute Carriers

Total Cost €

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EC-Contrib. €

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Partnership

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Project "TRECEPTORS" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 2˙050˙125 €
 EC max contribution 2˙050˙125 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-COG
 Funding Scheme ERC-COG
 Starting year 2018
 Duration (year-month-day) from 2018-04-01   to  2023-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 1˙480˙180.00
2    INSTITUT PASTEUR FR (PARIS CEDEX 15) participant 569˙945.00

Map

 Project objective

Human solute carriers (hSLC) form a superfamily of integral membrane proteins that transport small molecules and ions across membranes, and their transport functions are essential to processes ranging from synaptic transmission to apoptosis. Moreover, some hSLCs are the cellular receptors of human and pathogenic proteins, and play important roles in organogenesis, as well as infectious diseases. The hSLC transport and receptor functions are involved in a wide range of pathological conditions, which makes them important emerging drug targets in cancer, psychiatric disorders, and infectious diseases. Despite their paramount importance in human physiology and pathology, the current understanding of hSLCs molecular mechanisms of function and pharmacology still relies extensively on prokaryotic homologs that serve as structural and molecular models. However, due to the evolutionary divergence of these homologs, they fall short of uncovering the complexity of the hSLCs’ architectures and molecular mechanisms. Here, we aim to unravel novel transport, receptor and pharmacological mechanisms of medically important hSLCs using a multidisciplinary biophysical approach. To achieve this, we will determine the high-resolution structures of hSLCs and their macromolecular complexes with other membrane, as well as soluble proteins. Moreover, we will complement and challenge the structural data with functional approaches to probe the proteins dynamics and thermodynamics, as well as computational approaches to aid in drug discovery. Our research will expand our current molecular knowledge on the hSLCs, and aid understanding their cellular functions, as well as, uncovering their tremendous pharmacological potential.

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The information about "TRECEPTORS" are provided by the European Opendata Portal: CORDIS opendata.

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