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RECGLYCANMR SIGNED

Breaking the limits in glycan recognition by NMR

Total Cost €

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EC-Contrib. €

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Partnership

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 RECGLYCANMR project word cloud

Explore the words cloud of the RECGLYCANMR project. It provides you a very rough idea of what is the project "RECGLYCANMR" about.

exclusively    implications    discovering    roles    area    collaborators    refinement    exquisite    biological    infections    ray    mechanisms    doubled    position    diseases    ligand    bank    molecular    events    multidisciplinary    nmr    viscosity    virtually    decipher    deposited    break    drugs    biocontext    respect    conformers    water    carbohydrates    complexity    incorrect    synthesis    receptor    protein    prominent    biology    groundbreaking    handled    probes    recglycanmr    resolution    huge    perspective    limited    science    create    crowded    cell    variety    reflect    manipulate    bases    till    inflammation    nature    recognition    sugars    poorly    biophysics    am    full    vitro    health    sugar    presentation    network    chemical    interactions    interpreted    unexplored    highlighted    limits    viral    expertise    approaching    report    glycan    play    selectivity    diffraction    ambient    lack    complexes    solution    combining    protocols    flexible    employed    glycans    avenues    errors    dynamics    me    synthetic    data    mediated   

Project "RECGLYCANMR" data sheet

The following table provides information about the project.

Coordinator
ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOCIENCIAS 

Organization address
address: PARQUE TECNOLOGICO EDIFICIO 801 A
city: DERIO VIZCAYA
postcode: 48160
website: www.cicbiogune.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 2˙499˙980 €
 EC max contribution 2˙499˙980 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-ADG
 Funding Scheme ERC-ADG
 Starting year 2018
 Duration (year-month-day) from 2018-09-01   to  2023-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOCIENCIAS ES (DERIO VIZCAYA) coordinator 2˙499˙980.00

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 Project objective

Carbohydrates (glycans, sugars) play key roles in virtually all biological events. Given their chemical complexity, understanding their roles in nature requires a multidisciplinary approach. Research in the field is growing, since advances in the area could be part of the solution to many health issues. However, we lack full knowledge on the role of most glycan-mediated events especially at the resolution required from a chemical perspective to manipulate them and create new probes and eventually drugs. Understanding sugar recognition remains a major challenge in science. Although X-ray diffraction has been employed to study sugar/protein complexes, a recent report has highlighted that most sugar conformers deposited in the Protein Data Bank are incorrect. Flexible glycans are handled poorly in X-ray: errors reflect incorrect refinement of sugars, with huge implications when interpreted in the biocontext.I propose to address glycan recognition by using a multidisciplinary approach, combining synthesis, molecular biology and biophysics, with a prominent role for NMR. In RECGLYCANMR I will develop new NMR protocols to decipher key glycan recognition aspects beyond current knowledge: the role of presentation and dynamics and understanding the mechanisms behind the exquisite receptor and ligand selectivity. Importantly, till now, sugar recognition NMR studies have been exclusively limited to in vitro. RECGLYCANMR will break the limits of NMR, studying the interactions in-cell, a crowded ambient where viscosity is doubled respect to water. I am in a unique position to approach this project due to my wide expertise in NMR and the network of collaborators I have established for years, enabling me to access a large variety of synthetic sugars. Discovering the molecular bases of in-cell interactions will provide groundbreaking information on sugar chemical biology and will open unexplored avenues for approaching sugar-associated diseases, as inflammation and viral infections

 Publications

year authors and title journal last update
List of publications.
2020 Alexandra Bordes, Ana Poveda, Thibault Troadec, Antonio Franconetti, Ana Ardá, Flavie Perrin, Mickaël Ménand, Matthieu Sollogoub, Jerôme Guillard, Jérôme Désiré, Raphaël Tripier, Jesús Jiménez-Barbero, Yves Blériot
Synthesis, Conformational Analysis, and Complexation Study of an Iminosugar-Aza-Crown, a Sweet Chiral Cyclam Analog
published pages: 2344-2349, ISSN: 1523-7060, DOI: 10.1021/acs.orglett.0c00503
Organic Letters 22/6 2020-04-15
2020 Ana Gimeno, Pablo Valverde, Ana Ardá, Jesús Jiménez-Barbero
Glycan structures and their interactions with proteins. A NMR view
published pages: 22-30, ISSN: 0959-440X, DOI: 10.1016/j.sbi.2019.11.004
Current Opinion in Structural Biology 62 2020-04-15
2018 Beatriz Fernández de Toro, Wenjie Peng, Andrew J. Thompson, Gema Domínguez, F. Javier Cañada, Javier Pérez‐Castells, James C. Paulson, Jesús Jiménez‐Barbero, Ángeles Canales
Avenues to Characterize the Interactions of Extended N‐Glycans with Proteins by NMR Spectroscopy: The Influenza Hemagglutinin Case
published pages: 15051-15055, ISSN: 1433-7851, DOI: 10.1002/anie.201807162
Angewandte Chemie International Edition 57/46 2020-04-15
2019 Ana Gimeno, Sandra Delgado, Pablo Valverde, Sara Bertuzzi, Manuel Alvaro Berbís, Javier Echavarren, Alessandra Lacetera, Sonsoles Martín‐Santamaría, Avadhesha Surolia, Francisco Javier Cañada, Jesus Jiménez‐Barbero, Ana Ardá
Minimizing the Entropy Penalty for Ligand Binding: Lessons from the Molecular Recognition of the Histo Blood‐Group Antigens by Human Galectin‐3
published pages: 7268-7272, ISSN: 1433-7851, DOI: 10.1002/anie.201900723
Angewandte Chemie International Edition 58/22 2020-04-15
2019 Pablo Valverde, Ana Ardá, Niels-Christian Reichardt, Jesús Jiménez-Barbero, Ana Gimeno
Glycans in drug discovery
published pages: 1678-1691, ISSN: 2040-2503, DOI: 10.1039/c9md00292h
MedChemComm 10/10 2020-04-15
2019 J. Daniel Martínez, Pablo Valverde, Sandra Delgado, Cecilia Romanò, Bruno Linclau, Niels C. Reichardt, Stefan Oscarson, Ana Ardá, Jesús Jiménez-Barbero, F. Javier Cañada
Unraveling Sugar Binding Modes to DC-SIGN by Employing Fluorinated Carbohydrates
published pages: 2337, ISSN: 1420-3049, DOI: 10.3390/molecules24122337
Molecules 24/12 2020-04-15

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