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Biosensor Design SIGNED

Engineering Chemotactic Biosensors for a Diverse Spectrum of Metastatic Markers

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 Biosensor Design project word cloud

Explore the words cloud of the Biosensor Design project. It provides you a very rough idea of what is the project "Biosensor Design" about.

chemotaxis    potency    molecules    movement    form    engineered    engineering    scaffold    markers    tumors    therapeutics    elicit    receptor    points    organ    immune    harnessing    computational    nk    rational    niches    biophysical    opportunity    spectrum    secondary    soluble    environmental    molecular    sensing    barth    lethal    chemotactic    cancer    cancers    stringent    biosensors    seed    circulation    ultimately    immunosurveillance    diversity    receptors    extravasation    journey    cues    employ    malignant    structure    reaching    actions    proliferate    lab    synthetic    expand    migration    initiate    cell    secreted    metastasis    modulation    cytotoxic    initial    biologists    tumor    host    cells    techniques    escape    complexity    basic    distant    extensive    sites    intravasation    platform    biosensor    metastatic    extremely    membrane    chemokine    translational    computation    biology    relevance    fundamental    validate    protein    function    indicators    directional    migratory    vulnerable   

Project "Biosensor Design" data sheet

The following table provides information about the project.

Coordinator
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE 

Organization address
address: BATIMENT CE 3316 STATION 1
city: LAUSANNE
postcode: 1015
website: www.epfl.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 191˙149 €
 EC max contribution 191˙149 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-02-01   to  2022-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE CH (LAUSANNE) coordinator 191˙149.00

Map

 Project objective

Directional movement of cells in response to environmental cues (e.g. chemotaxis) is essential throughout biology, and the membrane receptors that initiate cell migration offer a key opportunity for modulation by synthetic biologists. The design of chemotactic receptor biosensors for metastatic markers has the potential to expand the immune system’s spectrum of actions. Metastatic cancers are extremely lethal, and tumor cells that escape to seed a secondary tumor in a distant organ often escape immunosurveillance. Extensive studies on metastasis have identified soluble secreted factors that promote the initial escape of tumor cells, their intravasation into circulation, and extravasation into metastatic niches where they can proliferate and form new malignant tumors. We will employ a host of computational design techniques developed in the Barth Lab to build novel biosensors that will elicit chemotactic responses towards molecular indicators of metastatic cells at various key points during their journey to secondary sites when they are vulnerable to engineered cytotoxic immune (T and NK) cells. By harnessing the migratory potency of a chemokine receptor scaffold, we will design several novel chemotactic receptors sensing molecules of increasing complexity to ultimately build and validate a general computation-based platform for rational biosensor design. At a fundamental level, engineering membrane receptors that can respond to a diversity of molecules is a stringent test of our biophysical understanding of protein structure and function, but also has far-reaching applications in basic and translational research with immediate relevance and impact for cancer therapeutics.

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The information about "BIOSENSOR DESIGN" are provided by the European Opendata Portal: CORDIS opendata.

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