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Biosensor Design SIGNED

Engineering Chemotactic Biosensors for a Diverse Spectrum of Metastatic Markers

Total Cost €

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EC-Contrib. €

0

Partnership

0

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 Biosensor Design project word cloud

Explore the words cloud of the Biosensor Design project. It provides you a very rough idea of what is the project "Biosensor Design" about.

secreted    chemokine    synthetic    employ    platform    complexity    form    protein    cells    host    circulation    barth    cell    function    ultimately    validate    potency    journey    initial    escape    rational    cancer    molecular    engineering    niches    opportunity    elicit    modulation    translational    spectrum    stringent    seed    receptor    organ    intravasation    soluble    chemotactic    structure    migratory    techniques    fundamental    molecules    cancers    biophysical    distant    sensing    scaffold    harnessing    chemotaxis    malignant    directional    nk    tumor    secondary    biosensor    engineered    movement    computation    relevance    environmental    biology    biologists    reaching    actions    immune    lethal    receptors    markers    extensive    metastatic    vulnerable    metastasis    points    cues    tumors    diversity    membrane    extravasation    migration    immunosurveillance    basic    extremely    sites    biosensors    cytotoxic    expand    proliferate    indicators    initiate    therapeutics    lab    computational   

Project "Biosensor Design" data sheet

The following table provides information about the project.

Coordinator
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE 

Organization address
address: BATIMENT CE 3316 STATION 1
city: LAUSANNE
postcode: 1015
website: www.epfl.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 191˙149 €
 EC max contribution 191˙149 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-02-01   to  2022-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE CH (LAUSANNE) coordinator 191˙149.00

Map

 Project objective

Directional movement of cells in response to environmental cues (e.g. chemotaxis) is essential throughout biology, and the membrane receptors that initiate cell migration offer a key opportunity for modulation by synthetic biologists. The design of chemotactic receptor biosensors for metastatic markers has the potential to expand the immune system’s spectrum of actions. Metastatic cancers are extremely lethal, and tumor cells that escape to seed a secondary tumor in a distant organ often escape immunosurveillance. Extensive studies on metastasis have identified soluble secreted factors that promote the initial escape of tumor cells, their intravasation into circulation, and extravasation into metastatic niches where they can proliferate and form new malignant tumors. We will employ a host of computational design techniques developed in the Barth Lab to build novel biosensors that will elicit chemotactic responses towards molecular indicators of metastatic cells at various key points during their journey to secondary sites when they are vulnerable to engineered cytotoxic immune (T and NK) cells. By harnessing the migratory potency of a chemokine receptor scaffold, we will design several novel chemotactic receptors sensing molecules of increasing complexity to ultimately build and validate a general computation-based platform for rational biosensor design. At a fundamental level, engineering membrane receptors that can respond to a diversity of molecules is a stringent test of our biophysical understanding of protein structure and function, but also has far-reaching applications in basic and translational research with immediate relevance and impact for cancer therapeutics.

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The information about "BIOSENSOR DESIGN" are provided by the European Opendata Portal: CORDIS opendata.

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