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Biosensor Design SIGNED

Engineering Chemotactic Biosensors for a Diverse Spectrum of Metastatic Markers

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 Biosensor Design project word cloud

Explore the words cloud of the Biosensor Design project. It provides you a very rough idea of what is the project "Biosensor Design" about.

scaffold    engineering    extravasation    movement    ultimately    structure    biologists    expand    computation    malignant    host    cells    nk    spectrum    translational    indicators    chemokine    rational    organ    secreted    complexity    elicit    molecular    tumors    initial    platform    tumor    immunosurveillance    metastatic    chemotactic    techniques    secondary    cell    validate    synthetic    biophysical    reaching    cytotoxic    environmental    sensing    molecules    biosensor    intravasation    soluble    lethal    metastasis    actions    employ    extensive    receptors    engineered    computational    function    lab    biology    diversity    cancers    chemotaxis    journey    modulation    immune    relevance    cancer    migration    membrane    circulation    points    opportunity    markers    potency    receptor    harnessing    escape    sites    niches    biosensors    proliferate    seed    extremely    therapeutics    vulnerable    cues    directional    initiate    barth    distant    migratory    protein    stringent    fundamental    form    basic   

Project "Biosensor Design" data sheet

The following table provides information about the project.

Coordinator
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE 

Organization address
address: BATIMENT CE 3316 STATION 1
city: LAUSANNE
postcode: 1015
website: www.epfl.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 191˙149 €
 EC max contribution 191˙149 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-02-01   to  2022-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE CH (LAUSANNE) coordinator 191˙149.00

Map

 Project objective

Directional movement of cells in response to environmental cues (e.g. chemotaxis) is essential throughout biology, and the membrane receptors that initiate cell migration offer a key opportunity for modulation by synthetic biologists. The design of chemotactic receptor biosensors for metastatic markers has the potential to expand the immune system’s spectrum of actions. Metastatic cancers are extremely lethal, and tumor cells that escape to seed a secondary tumor in a distant organ often escape immunosurveillance. Extensive studies on metastasis have identified soluble secreted factors that promote the initial escape of tumor cells, their intravasation into circulation, and extravasation into metastatic niches where they can proliferate and form new malignant tumors. We will employ a host of computational design techniques developed in the Barth Lab to build novel biosensors that will elicit chemotactic responses towards molecular indicators of metastatic cells at various key points during their journey to secondary sites when they are vulnerable to engineered cytotoxic immune (T and NK) cells. By harnessing the migratory potency of a chemokine receptor scaffold, we will design several novel chemotactic receptors sensing molecules of increasing complexity to ultimately build and validate a general computation-based platform for rational biosensor design. At a fundamental level, engineering membrane receptors that can respond to a diversity of molecules is a stringent test of our biophysical understanding of protein structure and function, but also has far-reaching applications in basic and translational research with immediate relevance and impact for cancer therapeutics.

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The information about "BIOSENSOR DESIGN" are provided by the European Opendata Portal: CORDIS opendata.

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