Opendata, web and dolomites

SEXinMALARIA SIGNED

Sex in malaria parasites – from basic biology to targets for transmission blocking interventions.

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 SEXinMALARIA project word cloud

Explore the words cloud of the SEXinMALARIA project. It provides you a very rough idea of what is the project "SEXinMALARIA" about.

zygote    mark    ko    erc    excellence    fertility    single    sexual    candidates    gene    primarily    transcriptomics    reverse    drug    simultaneous    biological    cell    changing    ranging    previously    functions    unprecedented    genes    am    molecular    game    hundreds    validated    ume    records    firmly    understand    malaria    majority    breaking    agenda    parasite    mutants    innovative    parallel    uk    mosquitoes    parasites    team    cycle    vivo    leveraging    differentiation    block    individuals    vaccines    power    phenotyping    plasmodium    elimination    conduct    centre    validate    unexplored    implications    aring    turning    vaccine    retaining    discoveries    ground    male    life    systematically    overcome    breadth    infected    slow    genetic    intractable    model    track    clear    map    pathogen    roles    outstanding    sex    translational    mechanisms    barcoded    transmission    builds    points    genome    point    female    relocating    university    massive    delivering    screen    genetics    reveal    hurdle    critically    biology    drugs    first    critical    27    disease   

Project "SEXinMALARIA" data sheet

The following table provides information about the project.

Coordinator
UMEA UNIVERSITET 

Organization address
address: UNIVERSITETOMRADET
city: UMEA
postcode: 901 87
website: www.umu.se

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Total cost 2˙500˙000 €
 EC max contribution 2˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-ADG
 Funding Scheme ERC-ADG
 Starting year 2018
 Duration (year-month-day) from 2018-09-01   to  2023-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UMEA UNIVERSITET SE (UMEA) coordinator 2˙500˙000.00

Map

 Project objective

Sexual development in malaria parasites is critical for disease transmission between infected individuals, and is therefore a major target for the malaria elimination agenda. However, there are currently no effective drugs or vaccines that block parasite transmission to mosquitoes, and we currently do not understand the molecular mechanisms involved. This is primarily because Plasmodium genetics has been slow, with the majority of the genome unexplored. I here propose to conduct the first genome-scale screen for male and/or female fertility genes by leveraging a game-changing genetic system we have developed and recently validated through the first genome-scale in vivo gene KO screen in any parasite. Using simultaneous phenotyping of barcoded mutants, we will conduct the first genome-scale screen for male and/or female fertility genes. My team will systematically map specific biological roles for hundreds of parasite genes, ranging from sex determination to zygote differentiation. We will also overcome the next hurdle in Plasmodium genetics by developing a method for massive parallel phenotyping, using the power of single cell transcriptomics to validate the screen and reveal molecular mechanisms at previously intractable points in the Plasmodium life cycle. This approach has clear translational implications, as it will identify both drug and vaccine candidates. This proposal builds firmly on my outstanding track records in delivering large reverse genetics projects and making ground-breaking discoveries in Plasmodium transmission biology. Its unprecedented breadth and depth will mark a turning point in how gene functions are studied in this important model parasite. I am relocating from the UK to Umeå University, a centre of excellence for pathogen research and innovative genetics, so retaining this important research in the EU of 27 will depend critically on ERC funding.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "SEXINMALARIA" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "SEXINMALARIA" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

LO-KMOF (2019)

Vapour-deposited metal-organic frameworks as high-performance gap-filling dielectrics for nanoelectronics

Read More  

TRUST (2018)

Truth and Semantics

Read More  

Resonances (2019)

Resonances and Zeta Functions in Smooth Ergodic Theory and Geometry

Read More