Opendata, web and dolomites

SEXinMALARIA SIGNED

Sex in malaria parasites – from basic biology to targets for transmission blocking interventions.

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 SEXinMALARIA project word cloud

Explore the words cloud of the SEXinMALARIA project. It provides you a very rough idea of what is the project "SEXinMALARIA" about.

cell    point    transmission    track    mark    mosquitoes    agenda    parasites    unprecedented    majority    differentiation    conduct    am    sexual    previously    breadth    plasmodium    27    barcoded    drugs    critically    genome    delivering    turning    phenotyping    gene    map    vivo    systematically    leveraging    sex    female    vaccines    breaking    candidates    ranging    biology    functions    retaining    outstanding    mechanisms    cycle    block    team    critical    centre    male    molecular    university    hundreds    massive    individuals    changing    biological    ground    reveal    uk    slow    relocating    genetic    model    firmly    validate    first    hurdle    understand    game    malaria    primarily    screen    simultaneous    translational    validated    vaccine    aring    power    unexplored    elimination    ko    genes    mutants    roles    pathogen    parallel    drug    intractable    innovative    implications    disease    zygote    clear    genetics    single    life    builds    infected    discoveries    points    erc    parasite    ume    reverse    excellence    overcome    fertility    transcriptomics    records   

Project "SEXinMALARIA" data sheet

The following table provides information about the project.

Coordinator
UMEA UNIVERSITET 

Organization address
address: UNIVERSITETOMRADET
city: UMEA
postcode: 901 87
website: www.umu.se

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Total cost 2˙500˙000 €
 EC max contribution 2˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-ADG
 Funding Scheme ERC-ADG
 Starting year 2018
 Duration (year-month-day) from 2018-09-01   to  2023-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UMEA UNIVERSITET SE (UMEA) coordinator 2˙500˙000.00

Map

 Project objective

Sexual development in malaria parasites is critical for disease transmission between infected individuals, and is therefore a major target for the malaria elimination agenda. However, there are currently no effective drugs or vaccines that block parasite transmission to mosquitoes, and we currently do not understand the molecular mechanisms involved. This is primarily because Plasmodium genetics has been slow, with the majority of the genome unexplored. I here propose to conduct the first genome-scale screen for male and/or female fertility genes by leveraging a game-changing genetic system we have developed and recently validated through the first genome-scale in vivo gene KO screen in any parasite. Using simultaneous phenotyping of barcoded mutants, we will conduct the first genome-scale screen for male and/or female fertility genes. My team will systematically map specific biological roles for hundreds of parasite genes, ranging from sex determination to zygote differentiation. We will also overcome the next hurdle in Plasmodium genetics by developing a method for massive parallel phenotyping, using the power of single cell transcriptomics to validate the screen and reveal molecular mechanisms at previously intractable points in the Plasmodium life cycle. This approach has clear translational implications, as it will identify both drug and vaccine candidates. This proposal builds firmly on my outstanding track records in delivering large reverse genetics projects and making ground-breaking discoveries in Plasmodium transmission biology. Its unprecedented breadth and depth will mark a turning point in how gene functions are studied in this important model parasite. I am relocating from the UK to Umeå University, a centre of excellence for pathogen research and innovative genetics, so retaining this important research in the EU of 27 will depend critically on ERC funding.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "SEXINMALARIA" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "SEXINMALARIA" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

Resonances (2019)

Resonances and Zeta Functions in Smooth Ergodic Theory and Geometry

Read More  

LO-KMOF (2019)

Vapour-deposited metal-organic frameworks as high-performance gap-filling dielectrics for nanoelectronics

Read More  

PLAT_ACE (2019)

A new platform technology for the on-demand access to large acenes

Read More