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SEXinMALARIA SIGNED

Sex in malaria parasites – from basic biology to targets for transmission blocking interventions.

Total Cost €

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EC-Contrib. €

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Partnership

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 SEXinMALARIA project word cloud

Explore the words cloud of the SEXinMALARIA project. It provides you a very rough idea of what is the project "SEXinMALARIA" about.

majority    overcome    biological    parallel    intractable    fertility    transmission    drug    phenotyping    malaria    builds    translational    life    ranging    reveal    model    sexual    cycle    relocating    mechanisms    simultaneous    changing    male    disease    drugs    vaccines    plasmodium    power    ume    validate    understand    block    firmly    critically    ko    genetics    uk    implications    vaccine    genes    reverse    unprecedented    parasite    team    agenda    track    mark    pathogen    aring    molecular    zygote    female    am    elimination    screen    massive    university    infected    breaking    leveraging    first    mutants    points    excellence    records    delivering    erc    individuals    barcoded    game    retaining    breadth    single    hurdle    parasites    outstanding    ground    27    previously    critical    clear    map    hundreds    centre    validated    genetic    unexplored    slow    cell    sex    discoveries    conduct    candidates    biology    gene    genome    systematically    differentiation    innovative    turning    vivo    transcriptomics    primarily    point    mosquitoes    roles    functions   

Project "SEXinMALARIA" data sheet

The following table provides information about the project.

Coordinator
UMEA UNIVERSITET 

Organization address
address: UNIVERSITETOMRADET
city: UMEA
postcode: 901 87
website: www.umu.se

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Total cost 2˙500˙000 €
 EC max contribution 2˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-ADG
 Funding Scheme ERC-ADG
 Starting year 2018
 Duration (year-month-day) from 2018-09-01   to  2023-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UMEA UNIVERSITET SE (UMEA) coordinator 2˙500˙000.00

Map

 Project objective

Sexual development in malaria parasites is critical for disease transmission between infected individuals, and is therefore a major target for the malaria elimination agenda. However, there are currently no effective drugs or vaccines that block parasite transmission to mosquitoes, and we currently do not understand the molecular mechanisms involved. This is primarily because Plasmodium genetics has been slow, with the majority of the genome unexplored. I here propose to conduct the first genome-scale screen for male and/or female fertility genes by leveraging a game-changing genetic system we have developed and recently validated through the first genome-scale in vivo gene KO screen in any parasite. Using simultaneous phenotyping of barcoded mutants, we will conduct the first genome-scale screen for male and/or female fertility genes. My team will systematically map specific biological roles for hundreds of parasite genes, ranging from sex determination to zygote differentiation. We will also overcome the next hurdle in Plasmodium genetics by developing a method for massive parallel phenotyping, using the power of single cell transcriptomics to validate the screen and reveal molecular mechanisms at previously intractable points in the Plasmodium life cycle. This approach has clear translational implications, as it will identify both drug and vaccine candidates. This proposal builds firmly on my outstanding track records in delivering large reverse genetics projects and making ground-breaking discoveries in Plasmodium transmission biology. Its unprecedented breadth and depth will mark a turning point in how gene functions are studied in this important model parasite. I am relocating from the UK to Umeå University, a centre of excellence for pathogen research and innovative genetics, so retaining this important research in the EU of 27 will depend critically on ERC funding.

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The information about "SEXINMALARIA" are provided by the European Opendata Portal: CORDIS opendata.

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