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SEXinMALARIA SIGNED

Sex in malaria parasites – from basic biology to targets for transmission blocking interventions.

Total Cost €

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EC-Contrib. €

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Partnership

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 SEXinMALARIA project word cloud

Explore the words cloud of the SEXinMALARIA project. It provides you a very rough idea of what is the project "SEXinMALARIA" about.

slow    molecular    leveraging    plasmodium    drug    screen    conduct    phenotyping    individuals    candidates    vivo    mechanisms    mosquitoes    parasite    pathogen    functions    reverse    centre    barcoded    builds    elimination    genes    validate    block    point    model    unexplored    retaining    primarily    critically    mark    records    ume    turning    aring    parallel    simultaneous    genetics    am    university    single    changing    sexual    ranging    parasites    track    sex    biological    life    cycle    cell    translational    delivering    genome    power    hundreds    differentiation    gene    reveal    fertility    uk    firmly    validated    transmission    discoveries    systematically    vaccines    points    hurdle    innovative    overcome    ko    unprecedented    27    massive    genetic    clear    roles    infected    understand    breaking    previously    malaria    female    map    zygote    disease    implications    team    male    breadth    critical    biology    intractable    vaccine    agenda    outstanding    relocating    erc    transcriptomics    first    majority    drugs    mutants    ground    excellence    game   

Project "SEXinMALARIA" data sheet

The following table provides information about the project.

Coordinator
UMEA UNIVERSITET 

Organization address
address: UNIVERSITETOMRADET
city: UMEA
postcode: 901 87
website: www.umu.se

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Total cost 2˙500˙000 €
 EC max contribution 2˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-ADG
 Funding Scheme ERC-ADG
 Starting year 2018
 Duration (year-month-day) from 2018-09-01   to  2023-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UMEA UNIVERSITET SE (UMEA) coordinator 2˙500˙000.00

Map

 Project objective

Sexual development in malaria parasites is critical for disease transmission between infected individuals, and is therefore a major target for the malaria elimination agenda. However, there are currently no effective drugs or vaccines that block parasite transmission to mosquitoes, and we currently do not understand the molecular mechanisms involved. This is primarily because Plasmodium genetics has been slow, with the majority of the genome unexplored. I here propose to conduct the first genome-scale screen for male and/or female fertility genes by leveraging a game-changing genetic system we have developed and recently validated through the first genome-scale in vivo gene KO screen in any parasite. Using simultaneous phenotyping of barcoded mutants, we will conduct the first genome-scale screen for male and/or female fertility genes. My team will systematically map specific biological roles for hundreds of parasite genes, ranging from sex determination to zygote differentiation. We will also overcome the next hurdle in Plasmodium genetics by developing a method for massive parallel phenotyping, using the power of single cell transcriptomics to validate the screen and reveal molecular mechanisms at previously intractable points in the Plasmodium life cycle. This approach has clear translational implications, as it will identify both drug and vaccine candidates. This proposal builds firmly on my outstanding track records in delivering large reverse genetics projects and making ground-breaking discoveries in Plasmodium transmission biology. Its unprecedented breadth and depth will mark a turning point in how gene functions are studied in this important model parasite. I am relocating from the UK to Umeå University, a centre of excellence for pathogen research and innovative genetics, so retaining this important research in the EU of 27 will depend critically on ERC funding.

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The information about "SEXINMALARIA" are provided by the European Opendata Portal: CORDIS opendata.

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