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SEXinMALARIA SIGNED

Sex in malaria parasites – from basic biology to targets for transmission blocking interventions.

Total Cost €

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EC-Contrib. €

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Partnership

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 SEXinMALARIA project word cloud

Explore the words cloud of the SEXinMALARIA project. It provides you a very rough idea of what is the project "SEXinMALARIA" about.

slow    mutants    agenda    transmission    genetics    first    27    validate    am    vaccine    power    conduct    screen    candidates    centre    barcoded    elimination    ranging    reveal    simultaneous    mark    turning    builds    outstanding    university    malaria    ground    innovative    gene    female    sexual    fertility    single    genome    translational    parallel    parasites    pathogen    critical    infected    drugs    genes    ko    discoveries    hundreds    validated    changing    clear    leveraging    uk    aring    reverse    model    map    biology    records    roles    sex    ume    mosquitoes    firmly    functions    point    breadth    team    overcome    systematically    parasite    disease    massive    unexplored    excellence    male    block    mechanisms    game    understand    biological    track    primarily    life    critically    intractable    genetic    cycle    cell    zygote    relocating    majority    molecular    differentiation    drug    breaking    delivering    unprecedented    transcriptomics    points    plasmodium    phenotyping    implications    previously    hurdle    vaccines    vivo    individuals    erc    retaining   

Project "SEXinMALARIA" data sheet

The following table provides information about the project.

Coordinator
UMEA UNIVERSITET 

Organization address
address: UNIVERSITETOMRADET
city: UMEA
postcode: 901 87
website: www.umu.se

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Total cost 2˙500˙000 €
 EC max contribution 2˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-ADG
 Funding Scheme ERC-ADG
 Starting year 2018
 Duration (year-month-day) from 2018-09-01   to  2023-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UMEA UNIVERSITET SE (UMEA) coordinator 2˙500˙000.00

Map

 Project objective

Sexual development in malaria parasites is critical for disease transmission between infected individuals, and is therefore a major target for the malaria elimination agenda. However, there are currently no effective drugs or vaccines that block parasite transmission to mosquitoes, and we currently do not understand the molecular mechanisms involved. This is primarily because Plasmodium genetics has been slow, with the majority of the genome unexplored. I here propose to conduct the first genome-scale screen for male and/or female fertility genes by leveraging a game-changing genetic system we have developed and recently validated through the first genome-scale in vivo gene KO screen in any parasite. Using simultaneous phenotyping of barcoded mutants, we will conduct the first genome-scale screen for male and/or female fertility genes. My team will systematically map specific biological roles for hundreds of parasite genes, ranging from sex determination to zygote differentiation. We will also overcome the next hurdle in Plasmodium genetics by developing a method for massive parallel phenotyping, using the power of single cell transcriptomics to validate the screen and reveal molecular mechanisms at previously intractable points in the Plasmodium life cycle. This approach has clear translational implications, as it will identify both drug and vaccine candidates. This proposal builds firmly on my outstanding track records in delivering large reverse genetics projects and making ground-breaking discoveries in Plasmodium transmission biology. Its unprecedented breadth and depth will mark a turning point in how gene functions are studied in this important model parasite. I am relocating from the UK to Umeå University, a centre of excellence for pathogen research and innovative genetics, so retaining this important research in the EU of 27 will depend critically on ERC funding.

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The information about "SEXINMALARIA" are provided by the European Opendata Portal: CORDIS opendata.

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