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SPeNTa-Brain SIGNED

Synthetic Peptidic Nanovesicles for Targeting Paediatric Brain tumours

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 SPeNTa-Brain project word cloud

Explore the words cloud of the SPeNTa-Brain project. It provides you a very rough idea of what is the project "SPeNTa-Brain" about.

pathologies    tumours    super    cancer    self    immunotherapy    crossing    opening    yielding    innovative    clinically    modulators    functionalised    cross    polymerisation    time    barrier    join    aqueous    binding    trojan    lies    blood    cns    first    rop    tumour    receptor    accounting    solid    immune    cancers    polypeptides    central    polymersomes    synergistic    glioma    assemble    strategies    difficulty    combination    selective    incurable    metastases    bbb    limitation    bottleneck    activate    combinations    transcytosis    wise    primary    critical    immuno    vesicles    death    nervous    deadliest    chemo    reaching    synthesise    fight    diffuse    ligands    acting    ncas    synthetic    selectivity    invasive    block    children    therapy    nanometric    reproducible    amphiphilic    horses    brain    scalable    treatment    carboxyanhydrides    anticancer    biodegradable    drug    nanovesicles    active    loaded    amphiphiles    methodology    overcome    solutions    situation    chemotherapy    stages    agents    25    polypeptide    resistance    paediatric    ring   

Project "SPeNTa-Brain" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY COLLEGE LONDON 

Organization address
address: GOWER STREET
city: LONDON
postcode: WC1E 6BT
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-04-01   to  2021-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY COLLEGE LONDON UK (LONDON) coordinator 183˙454.00

Map

 Project objective

Brain tumours are the most common solid tumours in children, accounting for about 25% of all primary paediatric tumours. The situation is particularly critical for the deadliest brain tumour: glioma, being the leading cause of cancer-related death in children. The main bottleneck for the treatment of central nervous system (CNS) pathologies, including brain tumours (at early stages), as well as brain metastases, lies in the difficulty to cross the blood brain barrier (BBB). In this proposal, I aim to overcome such limitation with the use of super-selective targeted and fully biodegradable polypeptide-based polymersomes, carrying relevant drug combinations for the treatment of paediatric glioma. I propose a step-wise and bottom-up approach to synthesise biodegradable polymersomes from amphiphilic block-polypeptides obtained via the scalable and reproducible methodology of Ring Opening Polymerisation (ROP) of N-Carboxyanhydrides (NCAs). The polypeptide amphiphiles are expected to self-assemble in aqueous solutions yielding nanometric vesicles. These synthetic vesicles will be functionalised with selected BBB receptor ligands in order to approach the super-selectivity concept aiming for active targeting and transcytosis to the brain acting as the so-called “Trojan Horses”. Finally, the super-selective nanovesicles will be loaded with synergistic and clinically relevant combination therapy using anticancer agents and immuno-modulators in order to approach paediatric glioma treatment. I will join for the first time, the use of fully biodegradable polymersomes based on polypeptides, super-selective binding strategies for BBB crossing and the use of chemotherapy immunotherapy. Overall, I will develop an innovative therapy, capable of reaching the brain in a non-invasive way, being able to diffuse and target the brain tumour, overcome chemo-resistance and activate the immune system to fight these tumours, being the future end-users, children with incurable cancers.

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The information about "SPENTA-BRAIN" are provided by the European Opendata Portal: CORDIS opendata.

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