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Extra-gonadal roles of Anti-Müllerian Hormone in the aetiology of polycystic ovary syndrome: the domino effect to reproductive neuroendocrine dysfunctions

Total Cost €


EC-Contrib. €






 REPRODAMH project word cloud

Explore the words cloud of the REPRODAMH project. It provides you a very rough idea of what is the project "REPRODAMH" about.

deficient    inhibition    infertility    neuronal    regulations    inferred    reproductive    hormone    oligo    strategies    preclinical    dysfunctions    10    biosynthesis    final    neuropeptide    anti    luteinizing    integrative    female    prevalence    women    alterations    animal    metabolic    pulse    relevance    modifications    developmental    endocrine    elevated    vivo    mouse    morbidities    combined    functional    hypothesis    diagnosis    intriguing    form    humans    patients    gnrh    disorders    mullerian    releasing    dependent    mammals    secretion    anovulation    polycystic    rescues    neuroendocrine    pcos    central    human    gonadotropin    mainly    syndrome    disturbances    nervous    gonadal    elusive    pathology    abnormal    interactions    accelerated    androgen    reproduction    excess    ovarian    plasticity    goals    models    therapeutic    fertility    leads    levels    investigations    reprodamh    ovary    clinical    hypothalamic    postnatal    lh    phenotype    secreting    amh    frequency    release    showed    frequent    acts    mechanistic    pathophysiology    structural    regulation    neurons    indicating    hyperactivation   

Project "REPRODAMH" data sheet

The following table provides information about the project.


Organization address
address: RUE DE TOLBIAC 101
city: PARIS
postcode: 75654

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙999˙740 €
 EC max contribution 1˙999˙740 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-COG
 Funding Scheme ERC-COG
 Starting year 2017
 Duration (year-month-day) from 2017-05-01   to  2022-04-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Reproduction in mammals is dependent on specific neurons secreting the Gonadotropin Hormone-Releasing Hormone (GnRH). Many reproductive disorders in humans are associated with abnormal or deficient GnRH secretion. Among reproductive dysfunctions, polycystic ovary syndrome (PCOS) is the most common form of female infertility with a prevalence of up to 10%, characterized by increased ovarian androgen biosynthesis, oligo-anovulation and frequent metabolic morbidities. Because women with PCOS have increased luteinizing hormone (LH) pulse frequency, it has been inferred that the pulse frequency of GnRH must be accelerated as well. However, so far PCOS has been considered mainly as a gonadal pathology and possible regulations from the central nervous system or interactions with it remain elusive. In patients with PCOS, ovarian levels of Anti-Mullerian Hormone (AMH) are also elevated, indicating the potential relevance of AMH for PCOS diagnosis and management. Recently, we showed that AMH acts directly on GnRH neurons to increase neuropeptide secretion, raising the intriguing hypothesis that AMH-dependent regulation of GnRH release could be involved in the neuroendocrine control of fertility and pathophysiology of PCOS. By providing integrative, functional and mechanistic in vivo strategies, combined with clinical human investigations, REPRODAMH will represent a major step forward into the understanding of PCOS with the final goal of developing new therapeutic strategies. To achieve these goals we will: 1: Determine whether developmental or postnatal AMH excess leads to PCOS endocrine disturbances by hyperactivation of GnRH neurons. 2: Study whether inhibition of GnRH neuronal activity rescues the neuroendocrine reproductive phenotype in PCOS-mouse models. 3: Study whether modifications of the hypothalamic structural plasticity occur in PCOS and contribute to alterations of GnRH release. 4: Design and test new preclinical therapeutic strategies in PCOS animal models.


year authors and title journal last update
List of publications.
2019 Samuel Andrew Malone, Georgios E Papadakis, Andrea Messina, Nour El Houda Mimouni, Sara Trova, Monica Imbernon, Cecile Allet, Irene Cimino, James Acierno, Daniele Cassatella, Cheng Xu, Richard Quinton, Gabor Szinnai, Pascal Pigny, Lur Alonso-Cotchico, Laura Masgrau, Jean-Didier Maréchal, Vincent Prevot, Nelly Pitteloud, Paolo Giacobini
Defective AMH signaling disrupts GnRH neuron development and function and contributes to hypogonadotropic hypogonadism
published pages: , ISSN: 2050-084X, DOI: 10.7554/elife.47198
eLife 8 2019-11-13
2018 Vincent Prevot, Bénédicte Dehouck, Ariane Sharif, Philippe Ciofi, Paolo Giacobini, Jerome Clasadonte
The Versatile Tanycyte: A Hypothalamic Integrator of Reproduction and Energy Metabolism
published pages: 333-368, ISSN: 0163-769X, DOI: 10.1210/er.2017-00235
Endocrine Reviews 39/3 2019-11-13
2019 Anne-Laure Barbotin, Maëliss Peigné, Samuel Andrew Malone, Paolo Giacobini
Emerging Roles of Anti-Müllerian Hormone in Hypothalamic-Pituitary Function
published pages: 218-229, ISSN: 0028-3835, DOI: 10.1159/000500689
Neuroendocrinology 109/3 2019-11-13
2018 Brooke Tata, Nour El Houda Mimouni, Anne-Laure Barbotin, Samuel A. Malone, Anne Loyens, Pascal Pigny, Didier Dewailly, Sophie Catteau-Jonard, Inger Sundström-Poromaa, Terhi T. Piltonen, Federica Dal Bello, Claudio Medana, Vincent Prevot, Jerome Clasadonte, Paolo Giacobini
Elevated prenatal anti-Müllerian hormone reprograms the fetus and induces polycystic ovary syndrome in adulthood
published pages: 834-846, ISSN: 1078-8956, DOI: 10.1038/s41591-018-0035-5
Nature Medicine 24/6 2019-05-29

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