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Hemodynamics in an Infarcted heart: from multi-physics Simulations to Medical analysis

Total Cost €


EC-Contrib. €






 HI-SiMed project word cloud

Explore the words cloud of the HI-SiMed project. It provides you a very rough idea of what is the project "HI-SiMed" about.

community    medical    treatment    code    framework    stresses    physiology    ing    vorticity    animated    dynamics    horizons    computational    models    electrophysiology    electro    capture    improvement    twente    flow    aorta    differences    mature    propels    building    diseases    ut    connecting    electrical    relaxation    mechanics    cycle    simed    fluid    neglecting    sex    hi    generates    pof    blood    functional    correlate    group    fundamental    vortex    cellular    myocardium    place    propagation    physics    pulsatile    biological    systemic    location    accounting    surrounding    university    reproduced    tool    fluids    accurate    provides    modify    heart    functioning    left    mechanical    science    cardiac    collaborating    innovative    topology    elastic    caused    structure    quantitative    structures    close    hemodynamics    outcomes    infarction    circulation    reproduce    deformation    surgeons    pumping    cooperation    model    wave    nowadays    contraction    ventricle    human    tissue    principal   

Project "HI-SiMed" data sheet

The following table provides information about the project.


Organization address
postcode: 7522 NB

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 165˙598 €
 EC max contribution 165˙598 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-09-01   to  2021-08-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITEIT TWENTE NL (ENSCHEDE) coordinator 165˙598.00


 Project objective

The left ventricle is the principal mechanical element of the human heart that propels blood to the systemic circulation. Its contraction is the result of an electrical wave propagation generated at the cellular level and is studied in the framework of cardiac electrophysiology. This science is nowadays mature and provides models to capture and reproduce the contraction/relaxation cycle of the heart that are used for a quantitative understanding of the heart functioning. However, these electrophysiology models do not include the hemodynamics caused by the ventricle deformation, thus neglecting the fundamental vortex dynamics taking place in the heart physiology, which generates stresses on the surrounding cardiac tissue. This project aims at connecting the electrophysiology and the fluid mechanics building an electro-fluid-structure computational model for the pulsatile flow in an animated left ventricle and elastic aorta. Biological heart conditions will be reproduced as close as possible by merging my electrophysiology code with the advanced fluid-structure framework of the Physics of Fluids group (PoF) at University of Twente (UT). The resulting multi-physics model will allow studying the accurate hemodynamics and cardiac tissue stresses generated in an animated ventricle. Building on my experience in vortex dynamics, we will correlate the topology of the vorticity structures with the heart functional pumping and then study how cardiac diseases such as myocardium infarction modify them, accounting for infarction location and sex differences. The outcomes of HI-SiMed will provide the medical community with an innovative and advanced tool that could open new horizons for the improvement of treatment outcomes. With this ambitious aim, the project will be developed in close cooperation with the cardiac surgeons already collaborating with the PoF.

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The information about "HI-SIMED" are provided by the European Opendata Portal: CORDIS opendata.

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