EU H2020 Project "HI-SIMED (Hemodynamics in an Infarcted heart: from multi-physics Simulations to Medical..)": description, partecipants, costs and EC-fundings

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HI-SiMed project word cloud

Explore the words cloud of the HI-SiMed project. It provides you a very rough idea of what is the project "HI-SiMed" about.

place correlate community fundamental structures propels myocardium animated surgeons left accurate surrounding human reproduced ing principal dynamics diseases mechanics computational modify structure biological caused science topology code tool group relaxation building pumping reproduce infarction twente university treatment connecting location cooperation cycle simed heart provides contraction quantitative accounting neglecting sex physiology electrophysiology hi propagation physics fluids vorticity cardiac elastic framework ut cellular close models blood wave flow improvement aorta functional circulation model pulsatile differences mature systemic mechanical functioning vortex innovative horizons ventricle electro stresses deformation generates capture medical collaborating pof electrical hemodynamics tissue nowadays outcomes fluid

Project "HI-SiMed" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITEIT TWENTE Organization address address: DRIENERLOLAAN 5 city: ENSCHEDE postcode: 7522 NB website: www.utwente.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Netherlands [NL]
Total cost	165˙598 €
EC max contribution	165˙598 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2017
Funding Scheme	MSCA-IF-EF-ST
Starting year	2019
Duration (year-month-day)	from 2019-09-01 to 2021-08-31

#	participants	country	role	EC contrib. [€]
1	UNIVERSITEIT TWENTE	NL (ENSCHEDE)	coordinator	165˙598.00

UNIVERSITEIT TWENTE

NL (ENSCHEDE)

coordinator

165˙598.00

Project objective

The left ventricle is the principal mechanical element of the human heart that propels blood to the systemic circulation. Its contraction is the result of an electrical wave propagation generated at the cellular level and is studied in the framework of cardiac electrophysiology. This science is nowadays mature and provides models to capture and reproduce the contraction/relaxation cycle of the heart that are used for a quantitative understanding of the heart functioning. However, these electrophysiology models do not include the hemodynamics caused by the ventricle deformation, thus neglecting the fundamental vortex dynamics taking place in the heart physiology, which generates stresses on the surrounding cardiac tissue. This project aims at connecting the electrophysiology and the fluid mechanics building an electro-fluid-structure computational model for the pulsatile flow in an animated left ventricle and elastic aorta. Biological heart conditions will be reproduced as close as possible by merging my electrophysiology code with the advanced fluid-structure framework of the Physics of Fluids group (PoF) at University of Twente (UT). The resulting multi-physics model will allow studying the accurate hemodynamics and cardiac tissue stresses generated in an animated ventricle. Building on my experience in vortex dynamics, we will correlate the topology of the vorticity structures with the heart functional pumping and then study how cardiac diseases such as myocardium infarction modify them, accounting for infarction location and sex differences. The outcomes of HI-SiMed will provide the medical community with an innovative and advanced tool that could open new horizons for the improvement of treatment outcomes. With this ambitious aim, the project will be developed in close cooperation with the cardiac surgeons already collaborating with the PoF.

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