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NEUROTARGET SIGNED

Treatment of traumatic brain injury using dye-loaded polymeric nanoparticles

Total Cost €

0

EC-Contrib. €

0

Partnership

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 NEUROTARGET project word cloud

Explore the words cloud of the NEUROTARGET project. It provides you a very rough idea of what is the project "NEUROTARGET" about.

exact    co    models    extra    photon    bbb    children    young    carriers    ultimately    action    secondary    np    injury    future    visualization    nanoparticles    poloxamer188    optimal    cutting    locations    consequently    clinical    extensive    blood    route    combine    treatments    drug    udisco    subsequently    neuroprotective    therapeutics    strategies    penetration    urgently    gain    despite    intact    safe    combination    platform    microscopy    traumatic    treatment    multiple    poly    minimizing    innovative    techniques    sub    unknown    adults    therapeutic    running    risk    edge    inability    body    potency    clearing    cargo    disability    cellular    synergistic    specificity    barrier    giving    obstacles    release    leader    translational    drugs    thereby    coated    plga    technologies    nano    compounds    laboratory    3d    bright    biodegradable    cells    tbi    trying    brain    distribute    technique    lactide    glycolide    damage    vivo    create    translation    host    mechanisms    treat    opportunity    cross   

Project "NEUROTARGET" data sheet

The following table provides information about the project.

Coordinator		 LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN 

Organization address
address: GESCHWISTER SCHOLL PLATZ 1
city: MUENCHEN
postcode: 80539
website: www.uni-muenchen.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Germany [DE]
 Total cost 171˙460 €
 EC max contribution 171˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-12-01   to  2020-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN DE (MUENCHEN) coordinator 171˙460.00

Map

 Project objective

Traumatic brain injury (TBI) is the number one cause of disability in children and young adults. Despite well-known mechanisms of secondary brain damage after TBI, effective treatments have not been yet established. Consequently, novel strategies to develop therapeutics which have translational potential are urgently required. One of the major obstacles when trying to treat the brain is the inability of drugs to cross the blood-brain barrier (BBB). Therefore, it is of great importance to develop novel strategies of drug delivery to targeted locations across the intact BBB. Poly(lactide-co-glycolide) nanoparticles (PLGA NP) are safe and biodegradable drug carriers. When coated with poloxamer188, they are able to cross the BBB. However, the exact mechanisms of penetration, as well as their route to target cells in the brain are currently unknown. To investigate this, the applicant will combine three cutting-edge technologies: novel extra-bright PLGA NP, in vivo two-photon microscopy and whole body clearing (uDISCO). These techniques in combination allow 3D visualization at the sub-cellular level of how PLGA NP distribute throughout the body, cross the BBB and release their cargo in vivo. These NP will subsequently be used as carriers to deliver multiple neuroprotective compounds with synergistic action into the brain. This technique allows high specificity and potency of therapeutic compounds, while minimizing the risk of side effects. Ultimately, objective of this approach is to create an optimal novel nano-platform for brain-targeted drug-delivery and based on this, to provide an innovative treatment of TBI that has the potential for clinical translation. Furthermore, the project will enable the applicant to gain extensive knowledge in advanced in vivo microscopy and TBI models, techniques that are well established in the host laboratory, thereby giving him the opportunity to become a leader in this novel field of research running his own research unit in the future

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The information about "NEUROTARGET" are provided by the European Opendata Portal: CORDIS opendata.

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