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NEUROTARGET SIGNED

Treatment of traumatic brain injury using dye-loaded polymeric nanoparticles

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 NEUROTARGET project word cloud

Explore the words cloud of the NEUROTARGET project. It provides you a very rough idea of what is the project "NEUROTARGET" about.

ultimately    opportunity    specificity    treat    exact    blood    poloxamer188    future    translational    co    technologies    therapeutics    locations    create    np    route    host    microscopy    urgently    udisco    obstacles    plga    treatment    nano    penetration    traumatic    running    potency    action    models    cross    3d    treatments    poly    bright    nanoparticles    carriers    strategies    subsequently    coated    visualization    platform    laboratory    combination    inability    injury    barrier    cargo    cutting    thereby    release    bbb    body    safe    children    mechanisms    lactide    adults    distribute    extra    innovative    glycolide    drugs    therapeutic    translation    risk    drug    combine    despite    secondary    edge    young    neuroprotective    minimizing    cellular    technique    giving    intact    consequently    cells    clearing    brain    clinical    tbi    photon    disability    multiple    optimal    gain    leader    extensive    unknown    synergistic    trying    damage    techniques    sub    compounds    biodegradable    vivo   

Project "NEUROTARGET" data sheet

The following table provides information about the project.

Coordinator
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN 

Organization address
address: GESCHWISTER SCHOLL PLATZ 1
city: MUENCHEN
postcode: 80539
website: www.uni-muenchen.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 171˙460 €
 EC max contribution 171˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-12-01   to  2020-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN DE (MUENCHEN) coordinator 171˙460.00

Map

 Project objective

Traumatic brain injury (TBI) is the number one cause of disability in children and young adults. Despite well-known mechanisms of secondary brain damage after TBI, effective treatments have not been yet established. Consequently, novel strategies to develop therapeutics which have translational potential are urgently required. One of the major obstacles when trying to treat the brain is the inability of drugs to cross the blood-brain barrier (BBB). Therefore, it is of great importance to develop novel strategies of drug delivery to targeted locations across the intact BBB. Poly(lactide-co-glycolide) nanoparticles (PLGA NP) are safe and biodegradable drug carriers. When coated with poloxamer188, they are able to cross the BBB. However, the exact mechanisms of penetration, as well as their route to target cells in the brain are currently unknown. To investigate this, the applicant will combine three cutting-edge technologies: novel extra-bright PLGA NP, in vivo two-photon microscopy and whole body clearing (uDISCO). These techniques in combination allow 3D visualization at the sub-cellular level of how PLGA NP distribute throughout the body, cross the BBB and release their cargo in vivo. These NP will subsequently be used as carriers to deliver multiple neuroprotective compounds with synergistic action into the brain. This technique allows high specificity and potency of therapeutic compounds, while minimizing the risk of side effects. Ultimately, objective of this approach is to create an optimal novel nano-platform for brain-targeted drug-delivery and based on this, to provide an innovative treatment of TBI that has the potential for clinical translation. Furthermore, the project will enable the applicant to gain extensive knowledge in advanced in vivo microscopy and TBI models, techniques that are well established in the host laboratory, thereby giving him the opportunity to become a leader in this novel field of research running his own research unit in the future

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The information about "NEUROTARGET" are provided by the European Opendata Portal: CORDIS opendata.

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