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NEUROTARGET SIGNED

Treatment of traumatic brain injury using dye-loaded polymeric nanoparticles

Total Cost €

0

EC-Contrib. €

0

Partnership

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 NEUROTARGET project word cloud

Explore the words cloud of the NEUROTARGET project. It provides you a very rough idea of what is the project "NEUROTARGET" about.

cellular    penetration    compounds    techniques    cargo    cells    technologies    specificity    translation    poloxamer188    treat    giving    thereby    coated    minimizing    injury    combine    strategies    optimal    create    combination    translational    sub    technique    bbb    tbi    safe    inability    synergistic    np    ultimately    cutting    gain    brain    poly    exact    treatment    bright    distribute    udisco    extensive    mechanisms    running    extra    clearing    future    nanoparticles    young    leader    despite    risk    secondary    glycolide    carriers    adults    3d    children    cross    route    vivo    therapeutic    multiple    drug    co    platform    edge    therapeutics    photon    release    obstacles    laboratory    unknown    plga    locations    nano    drugs    potency    microscopy    damage    barrier    trying    body    host    traumatic    subsequently    lactide    biodegradable    visualization    innovative    treatments    intact    models    urgently    blood    action    neuroprotective    disability    clinical    opportunity    consequently   

Project "NEUROTARGET" data sheet

The following table provides information about the project.

Coordinator		 LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN 

Organization address
address: GESCHWISTER SCHOLL PLATZ 1
city: MUENCHEN
postcode: 80539
website: www.uni-muenchen.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Germany [DE]
 Total cost 171˙460 €
 EC max contribution 171˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-12-01   to  2020-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN DE (MUENCHEN) coordinator 171˙460.00

Map

 Project objective

Traumatic brain injury (TBI) is the number one cause of disability in children and young adults. Despite well-known mechanisms of secondary brain damage after TBI, effective treatments have not been yet established. Consequently, novel strategies to develop therapeutics which have translational potential are urgently required. One of the major obstacles when trying to treat the brain is the inability of drugs to cross the blood-brain barrier (BBB). Therefore, it is of great importance to develop novel strategies of drug delivery to targeted locations across the intact BBB. Poly(lactide-co-glycolide) nanoparticles (PLGA NP) are safe and biodegradable drug carriers. When coated with poloxamer188, they are able to cross the BBB. However, the exact mechanisms of penetration, as well as their route to target cells in the brain are currently unknown. To investigate this, the applicant will combine three cutting-edge technologies: novel extra-bright PLGA NP, in vivo two-photon microscopy and whole body clearing (uDISCO). These techniques in combination allow 3D visualization at the sub-cellular level of how PLGA NP distribute throughout the body, cross the BBB and release their cargo in vivo. These NP will subsequently be used as carriers to deliver multiple neuroprotective compounds with synergistic action into the brain. This technique allows high specificity and potency of therapeutic compounds, while minimizing the risk of side effects. Ultimately, objective of this approach is to create an optimal novel nano-platform for brain-targeted drug-delivery and based on this, to provide an innovative treatment of TBI that has the potential for clinical translation. Furthermore, the project will enable the applicant to gain extensive knowledge in advanced in vivo microscopy and TBI models, techniques that are well established in the host laboratory, thereby giving him the opportunity to become a leader in this novel field of research running his own research unit in the future

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The information about "NEUROTARGET" are provided by the European Opendata Portal: CORDIS opendata.

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