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NLR_NLR-ID power SIGNED

NLR-ID diversity, mechanism and functionality upon transfer between species

Total Cost €

0

EC-Contrib. €

0

Partnership

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 NLR_NLR-ID power project word cloud

Explore the words cloud of the NLR_NLR-ID power project. It provides you a very rough idea of what is the project "NLR_NLR-ID power" about.

animal    capture    head    solanaceae    helper    maximizing    pathogen    restricted    domains    dna    transferred    discover    molecular    prr    fellowship    confers    profound    completely    confer    receptors    gene    bacterial    cell    diseases    closely    rrs1    ids    pattern    arabidopsis    resistant    full    appropriate    that    barley    diverse    requirement    transfer    lines    effector    id    arise    rps4    taxonomic    defences    action    effectors    genotypes    innate    nlrs    recognition    surface    functional    insights    fungal    plants    rice    baits    rusts    nlr    disease    function    serve    activate    repertoires    nucleotide    receptor    carry    cucurbit    binding    goals    diversity    repeat    outcomes    species    poaceae    pairs    sequence    leucine    bioinformatics    linked    resistance    usually    host    basis    infection    detect    immune    families    pathogens    wheat    transgenic    interdisciplinary    hypothesis    pair    intracellular    class    proteins    interactions    plant   

Project "NLR_NLR-ID power" data sheet

The following table provides information about the project.

Coordinator
THE SAINSBURY LABORATORY 

Organization address
address: Norwich Research Park, Colney Lane
city: NORWICH
postcode: NR47UH
website: http://www.tsl.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-05-01   to  2020-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE SAINSBURY LABORATORY UK (NORWICH) coordinator 195˙454.00

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 Project objective

Plant and animal innate immune systems detect pathogen infection by both cell-surface PRR (pattern recognition receptor) and intracellular NLR (nucleotide-binding leucine-rich repeat) immune receptors, and activate effective defences. Transfer of cell surface receptors between plant families can enhance disease resistance, but intracellular receptors are often non-functional when transferred to different families. This 'restricted taxonomic functionality' may arise from a requirement for an appropriate helper or partner NLR. Some NLRs carry Integrated Domains (IDs) that serve as “baits” that detect the action of pathogen effector proteins, thus enabling pathogen recognition. NLR-ID proteins require for function a helper NLR, usually closely linked as a head-to-head gene pair. Some NLR/NLR-ID pairs confer resistance to diverse pathogens when transferred as a unit between plant families. For example, Arabidopsis RPS4/RRS1, when transferred as a unit, confers recognition of bacterial and fungal pathogens in Solanaceae and cucurbit plants. This project is based on the hypothesis that NLR/NLR-ID pairs from one species can detect effectors that target that class of ID from a pathogen of any species. Rice is completely resistant to fungal rusts of wheat and barley. Many NLR-IDs are present in rice but not in other Poaceae. My goals are to: (i) use DNA sequence capture and bioinformatics to discover the full NLR/NLR-ID pair repertoires of diverse rice genotypes; (ii) investigate rice IDs interactions with effectors from wheat and barley pathogens; and (iii) transfer gene pairs to barley, maximizing the diversity of IDs in these pairs, and assess transgenic lines for novel resistance to barley diseases. The outcomes of this interdisciplinary Fellowship will provide profound insights into NLR/NLR-ID diversity in plants, into the diversity of domains that are effector targets, and into the molecular basis of 'non-host' disease resistance.

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