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GPCR-Sensor SIGNED

GPCR-based biosensor for synthetic biology applications

Total Cost €

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EC-Contrib. €

0

Partnership

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 GPCR-Sensor project word cloud

Explore the words cloud of the GPCR-Sensor project. It provides you a very rough idea of what is the project "GPCR-Sensor" about.

instrumental    recognition    establishing    pollutants    synthetic    plugging    expertise    frequently    coupled    lack    biosynthetic    receptors    hosts    optimized    pathogen    leadership    yields    hurdles    competitive    biotechnology    sensor    close    strains    industrially    encountered    epitopes    samples    independent    limitation    accumulation    pharmaceuticals    permits    environment    biochemical    diagnostics    enzymes    versatile    training    valuable    mentoring    teaching    protein    skills    engineering    monitoring    academic    enzyme    extensive    combine    vivo    entities    gpcrs    biosynthesis    industrial    medical    rising    economical    structure    bio    biology    integral    fund    sense    natural    chemicals    efficient    enzymology    factories    metabolic    acquire    modular    molecular    me    create    biosensor    launching    yeast    professional    powerful    career    gpcr    variety    line    environmental    internationally    eukaryotes    cell    interdisciplinary    throughput    harness    discovery    microbial    communication    drug    alternative    overcome    principles    sustainable   

Project "GPCR-Sensor" data sheet

The following table provides information about the project.

Coordinator
KOBENHAVNS UNIVERSITET 

Organization address
address: NORREGADE 10
city: KOBENHAVN
postcode: 1165
website: www.ku.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 207˙312 €
 EC max contribution 207˙312 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-06-01   to  2022-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) coordinator 207˙312.00

Map

 Project objective

Microbial cell factories are an economical and sustainable alternative for the production of pharmaceuticals, industrial chemicals and other valuable chemicals. However, establishing efficient cell factories requires optimized production strains and efficient biosynthetic enzymes, and involves extensive protein and metabolic engineering to achieve industrially relevant yields. One of the main hurdles frequently encountered in this process is the lack of high-throughput methods for monitoring product accumulation. To overcome this limitation, I will harness G-protein coupled receptors (GPCRs), the unique molecular entities that eukaryotes use to sense their environment, to create a versatile in vivo biosensor. I will apply synthetic biology principles and an interdisciplinary approach to develop a yeast-based GPCR biosensor for the engineering of enzymes and production hosts. However, enzyme engineering is only one of the potential applications of GPCR-sensor. Its modular structure permits plugging in any GPCR, enabling a great variety of other powerful applications including bio-medical applications, such as recognition of pathogen epitopes, molecular diagnostics and drug discovery, or environmental applications, such as determining the presence of pollutants from environmental samples. In the GPCR-sensor project, I will combine my knowledge in natural product biosynthesis and enzymology with training in biochemical engineering and biotechnology to acquire a unique expertise that will help me establish my own unique line of research. Furthermore, the comprehensive professional development program, that is an integral part of GPCR-sensor, includes close mentoring in addition to training in fund-rising, research management, communication, teaching and academic leadership. These skills that are Instrumental for launching my future independent internationally competitive research career

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The information about "GPCR-SENSOR" are provided by the European Opendata Portal: CORDIS opendata.

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