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ONCOTHERANOSTICS SIGNED

Advanced Theranostic Nanomedicines for Oncology. Development of new combinatorial therapies for primary and metastatic Breast Cancer.

Total Cost €

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EC-Contrib. €

0

Partnership

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 ONCOTHERANOSTICS project word cloud

Explore the words cloud of the ONCOTHERANOSTICS project. It provides you a very rough idea of what is the project "ONCOTHERANOSTICS" about.

cells    single    negative    vivo    globally    multidisciplinary    agent    malignancy    2nd    dual    strategies    tumor    kinase    treat    metastatic    triggers    environment    host    techniques    intervention    invasively    theranostics    personalized    death    reinforcing    primary    triple    interplay    establishment    cancer    boosting    oncotheranostics    uses    combining    genetic    personalize    provides    completion    mechanisms    anticipate    genes    despite    personalizing    training    multiple    knocking    choline    surveillance    imaging    synthesis    formulation    tumoral    incoming    escaping    immune    proposes    treatment    safer    organic    successful    therapeutic    outgoing    diagnostic    expertise    line    health    dr    theranostic    care    breast    nanomedicine    multimodal    cross    combinatorial    multifaceted    mri    transferred    nanomedine    trained    therapies    pacheco    nanoparticle    treatments    cutting    sirna    natural    model    competitiveness    molecular    monitor    immunotherapy    purpose    chemist    effect    biology    downregulation    rendering   

Project "ONCOTHERANOSTICS" data sheet

The following table provides information about the project.

Coordinator
AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS 

Organization address
address: CALLE SERRANO 117
city: MADRID
postcode: 28006
website: http://www.csic.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 257˙191 €
 EC max contribution 257˙191 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-GF
 Starting year 2019
 Duration (year-month-day) from 2019-03-01   to  2022-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS ES (MADRID) coordinator 257˙191.00
2    JOHNS HOPKINS UNIVERSITY US (BALTIMORE) partner 0.00

Map

 Project objective

Despite significant advances in recent years, cancer remains the 2nd cause of death globally. Immunotherapy is an exciting new therapeutic approach that triggers natural immune response against cancer cells. Theranostics is an emerging therapeutic intervention, that uses dual (or multiple) purpose nanomedine, combining diagnostic and therapeutic effects within a single multifaceted formulation. ONCOTHERANOSTICS proposes the use of a novel theranostic agent to target key tumoral genes by siRNA and monitor the impact of the downregulation non-invasively in vivo. Specific aims include understanding the interplay between choline kinase and tumor escaping natural immune surveillance, and to develop new combinatorial therapies in a model of primary and metastatic triple negative breast cancer. We anticipate that successful completion of the project will result in significant advances in personalized tumor treatments, rendering safer strategies to treat cancer with a dual effect; boosting natural immune response and knocking down one of the main mechanisms of malignancy. Dr. Pacheco is an organic chemist with expertise in MRI who will be trained (outgoing) in nanoparticle synthesis, non-MRI imaging techniques and advanced molecular biology/genetic approaches. Training will be transferred to the host European institution (incoming) by the establishment of a new research line in the emerging field of Theranostics. ONCOTHERANOSTICS seeks to improve our understanding of cancer and how to personalize treatments, fostering the development of nanomedicine targeting specific genes in a way that can be assessed non-invasively. ONCOTHERANOSTICS provides a multidisciplinary environment for cancer treatment, involving multifaceted nanomedicine, multimodal molecular imaging and molecular biology/genetic approaches. The proposal directly addresses the cross cutting priority of personalizing health and care established by H2020, reinforcing European competitiveness in cancer research.

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The information about "ONCOTHERANOSTICS" are provided by the European Opendata Portal: CORDIS opendata.

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