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SCOUT SIGNED

Supporting Causal Conclusions from Observational Survival Studies

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 SCOUT project word cloud

Explore the words cloud of the SCOUT project. It provides you a very rough idea of what is the project "SCOUT" about.

trials    alter    guarantees    estimates    involvement    patient    soft    suggested    combine    shift    independence    components    interpretability    ease    group    prerequisites    treat    administration    alternative    rare    penalized    description    ultimately    interaction    effect    connections    outcome    interdisciplinary    fill    secondment    novartis    active    inference    interventions    career    supervisor    mechanisms    perception    statistical    international    innovative    expertise    skill    causal    seminars    utilize    underlying    survival    medical    paradigm    public    intention    techniques    institutional    paths    scientific    primary    context    mutual    aalen    methodology    estimands    hazards    intervention    elucidate    series    touch    empirical    applicability    analytical    assumptions    reasoning    gaps    basel    additive    cox    first    environment    framework    intersectoral    sparse    mediation    clinical    stakeholders    model    proportional    participation    action    data    drugs    regarding   

Project "SCOUT" data sheet

The following table provides information about the project.

Coordinator
MEDIZINISCHE UNIVERSITAET WIEN 

Organization address
address: SPITALGASSE 23
city: WIEN
postcode: 1090
website: www.meduniwien.ac.at

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Austria [AT]
 Total cost 166˙156 €
 EC max contribution 166˙156 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2018
 Duration (year-month-day) from 2018-10-01   to  2020-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MEDIZINISCHE UNIVERSITAET WIEN AT (WIEN) coordinator 166˙156.00

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 Project objective

The focus of my proposal is on statistical mediation analysis in medical studies with patient survival as outcome. Mediation analysis can help to elucidate the underlying mechanisms and ultimately to alter and further improve components of an intervention or shift the target of an intervention. Specifically, in aim 1 we utilize penalized likelihood techniques in an innovative way to improve mediation analysis with sparse data, e.g. rare side effects of drugs. Aim 2 will focus on the Aalen additive hazards model, an alternative to the Cox proportional hazards model, in particular when causal inference and mediation is of primary interest. We will consider a series of case studies comparing Aalen additive hazards model with the Cox proportional hazards model regarding interpretability of effect estimates, ease of application, applicability of assumptions, ease of description in an interdisciplinary context and public perception. By means of analytical reasoning and empirical studies we fill important gaps in knowledge, while the interdisciplinary working environment and intersectoral seminars will ensure that the achieved advances reach the relevant stakeholders. During the secondment at the Novartis Statistical Methodology Group in Basel, I will get in touch with mediation analysis for interventions in clinical trials and its connections to the estimands framework, which is currently being considered a promising alternative to the intention-to-treat paradigm as first principle in evaluating effects of interventions. The suggested action will combine my supervisor's and my scientific expertise and international experience at its best and thus guarantees mutual growth. Interaction with a highly active research group, participation in the institutional programme for soft skill development and involvement in project administration will further contribute to my development towards independence and are important prerequisites for various career paths.

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The information about "SCOUT" are provided by the European Opendata Portal: CORDIS opendata.

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