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SCOUT SIGNED

Supporting Causal Conclusions from Observational Survival Studies

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 SCOUT project word cloud

Explore the words cloud of the SCOUT project. It provides you a very rough idea of what is the project "SCOUT" about.

treat    penalized    touch    assumptions    first    effect    context    career    aalen    interdisciplinary    basel    gaps    participation    combine    scientific    estimands    international    applicability    ultimately    empirical    trials    statistical    seminars    connections    guarantees    rare    alter    supervisor    group    sparse    hazards    reasoning    primary    components    environment    administration    methodology    fill    public    proportional    utilize    paradigm    mechanisms    shift    description    novartis    stakeholders    drugs    regarding    data    interpretability    estimates    series    expertise    intersectoral    interventions    secondment    underlying    techniques    paths    soft    prerequisites    survival    patient    active    outcome    model    suggested    intervention    independence    intention    skill    alternative    cox    ease    inference    perception    elucidate    interaction    mutual    innovative    mediation    additive    action    causal    analytical    medical    institutional    involvement    framework    clinical   

Project "SCOUT" data sheet

The following table provides information about the project.

Coordinator
MEDIZINISCHE UNIVERSITAET WIEN 

Organization address
address: SPITALGASSE 23
city: WIEN
postcode: 1090
website: www.meduniwien.ac.at

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Austria [AT]
 Total cost 166˙156 €
 EC max contribution 166˙156 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2018
 Duration (year-month-day) from 2018-10-01   to  2020-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MEDIZINISCHE UNIVERSITAET WIEN AT (WIEN) coordinator 166˙156.00

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 Project objective

The focus of my proposal is on statistical mediation analysis in medical studies with patient survival as outcome. Mediation analysis can help to elucidate the underlying mechanisms and ultimately to alter and further improve components of an intervention or shift the target of an intervention. Specifically, in aim 1 we utilize penalized likelihood techniques in an innovative way to improve mediation analysis with sparse data, e.g. rare side effects of drugs. Aim 2 will focus on the Aalen additive hazards model, an alternative to the Cox proportional hazards model, in particular when causal inference and mediation is of primary interest. We will consider a series of case studies comparing Aalen additive hazards model with the Cox proportional hazards model regarding interpretability of effect estimates, ease of application, applicability of assumptions, ease of description in an interdisciplinary context and public perception. By means of analytical reasoning and empirical studies we fill important gaps in knowledge, while the interdisciplinary working environment and intersectoral seminars will ensure that the achieved advances reach the relevant stakeholders. During the secondment at the Novartis Statistical Methodology Group in Basel, I will get in touch with mediation analysis for interventions in clinical trials and its connections to the estimands framework, which is currently being considered a promising alternative to the intention-to-treat paradigm as first principle in evaluating effects of interventions. The suggested action will combine my supervisor's and my scientific expertise and international experience at its best and thus guarantees mutual growth. Interaction with a highly active research group, participation in the institutional programme for soft skill development and involvement in project administration will further contribute to my development towards independence and are important prerequisites for various career paths.

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The information about "SCOUT" are provided by the European Opendata Portal: CORDIS opendata.

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