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FATarget SIGNED

Drugs targets in sympathetic neurons controlling adiposity.

Total Cost €

0

EC-Contrib. €

0

Partnership

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Project "FATarget" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD 

Organization address
address: WELLINGTON SQUARE UNIVERSITY OFFICES
city: OXFORD
postcode: OX1 2JD
website: www.ox.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-06-03   to  2021-06-02

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD UK (OXFORD) coordinator 183˙454.00

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 Project objective

Obesity is a metabolic disorder with unmet medical need for which a pharmacotherapy is urgently needed. The Domingos lab has recently discovered that sympathetic (SNS) neuro-adipose junctions mediate lipolysis and fat mass reduction (Pirzgalska, R.M., Cell, 2015).Thus direct and targeted activation of sympathetic inputs to adipose tissues could represent a new strategy for the induction of fat loss. Our main objective is to identify drug targets in SNS neurons innervating fat, which are suitable for an anti-obesity therapy. To achieve this, we will use technologies such as Translational Ribosome Affinity Purification (TRAP) for translational profiling of neurons innervating fat. We will differentially screen for molecular targets that are enriched in SNS neurons in fat. We will validate target expression in human SNS tissues. This project will identify neuro-excitatory drug targets in sympathetic inputs to adipose tissues, and may lead the development of pharmacotherapies which would circumvent side effects.

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The information about "FATARGET" are provided by the European Opendata Portal: CORDIS opendata.

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