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MECoCaM SIGNED

Human gut Microbiome, gene Expression and Colorectal Cancer: Assigning causal roles from a novel Mendelian randomization perspective.

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 MECoCaM project word cloud

Explore the words cloud of the MECoCaM project. It provides you a very rough idea of what is the project "MECoCaM" about.

markers    germ    aetiology    transcriptomic    colon    cells    stages    cancer    assuming    exposure    influenced    validated    risk    identification    line    colorectal    variation    mendelian    manner    unravelling    tumour    microbial    site    layer    biopsies    samples    integrate    inflammatory    mr    proliferation    understand    therapeutic    confounding    functional    exposures    randomization    causal    500    microbe    analytical    causality    gut    enrichment    integrating    causation    ecosystem    mechanistic    carcinogenesis    correlations    microbes    pleiotropy    strategies    whereby    reverse    putative    proxied    mediators    interactions    proxies    genetic    relevance    epithelial    assume    interaction    unbalance    omic    environmental    additionally    mucosa    instrumental    contribution    variables    gene    communities    association    host    microbiome    normal    cell    estimates    epithelium    outcome    prevention    data    absence    description    phenotyped    assign    indicate    sequencing    unconfounded    crc    expression    intestinal   

Project "MECoCaM" data sheet

The following table provides information about the project.

Coordinator
FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE 

Organization address
address: AVENIDA GRAN VIA HOSPITALET 199-203
city: L'HOSPITALET DE LLOBREGAT
postcode: 8908
website: www.idibell.cat

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 158˙121 €
 EC max contribution 158˙121 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-09-03   to  2020-09-02

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE ES (L'HOSPITALET DE LLOBREGAT) coordinator 158˙121.00

Map

 Project objective

The contribution of the gut microbial ecosystem to colorectal cancer (CRC) is not well understood. Inflammatory processes and unbalance cell proliferation in the host could be behind observed correlations between a microbe and cancer stages. However, the enrichment of a microbe at a tumour site does not directly assume causation. Rather, this could be the result of a reverse causation or a confounding third factor. Therefore, two major challenges unravelling CRC aetiology are (i) to identify the mechanistic interactions of microbial communities with host intestinal epithelium cells, and (ii) to assign causality to carcinogenesis. These are the aims of this project integrating different “omic” data, and using a Mendelian randomization (MR) approach. In this study we analyse microbiome sequencing data, from up to 500 normal colon mucosa biopsies, to provide a comprehensive description of the gut microbiome. Additionally, we integrate transcriptomic data from these well phenotyped 500 samples to understand the interaction between microbes and the gut epithelial cells. Finally, using the germ-line genetic variation of host cells as a third “omic” layer, the correlations between microbes and (i) environmental exposures, (ii) gene expression, and (iii) CRC can be validated by MR. MR is an analytical approach whereby germ-line genetic markers are used as proxies – or instrumental variables – for putative risk factors. These genetic markers cannot be influenced by reverse causation, and, assuming an absence of pleiotropy, can provide unconfounded estimates of association. Therefore, a MR association between genetic proxies and the outcome of interest would indicate that the exposure being proxied is associated in a causal manner. The identification of the functional relevance and key mediators of gut microbiome to colorectal cancer development is going to increase the development of therapeutic approaches and prevention strategies.

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The information about "MECOCAM" are provided by the European Opendata Portal: CORDIS opendata.

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