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MECoCaM SIGNED

Human gut Microbiome, gene Expression and Colorectal Cancer: Assigning causal roles from a novel Mendelian randomization perspective.

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 MECoCaM project word cloud

Explore the words cloud of the MECoCaM project. It provides you a very rough idea of what is the project "MECoCaM" about.

aetiology    variation    gut    validated    epithelium    carcinogenesis    stages    expression    unravelling    tumour    assign    reverse    transcriptomic    integrating    unconfounded    proxied    whereby    ecosystem    data    microbes    line    analytical    cells    cancer    manner    mendelian    gene    instrumental    assume    exposure    therapeutic    inflammatory    causal    layer    genetic    microbiome    mr    microbial    contribution    microbe    additionally    strategies    influenced    association    markers    unbalance    risk    500    site    phenotyped    estimates    putative    confounding    environmental    crc    normal    correlations    causation    assuming    germ    understand    proxies    colon    communities    causality    randomization    outcome    enrichment    colorectal    sequencing    description    pleiotropy    mechanistic    prevention    biopsies    variables    cell    samples    proliferation    host    omic    absence    intestinal    integrate    interactions    interaction    mucosa    exposures    relevance    indicate    identification    functional    mediators    epithelial   

Project "MECoCaM" data sheet

The following table provides information about the project.

Coordinator
FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE 

Organization address
address: AVENIDA GRAN VIA HOSPITALET 199-203
city: L'HOSPITALET DE LLOBREGAT
postcode: 8908
website: www.idibell.cat

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 158˙121 €
 EC max contribution 158˙121 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-09-03   to  2020-09-02

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE ES (L'HOSPITALET DE LLOBREGAT) coordinator 158˙121.00

Map

 Project objective

The contribution of the gut microbial ecosystem to colorectal cancer (CRC) is not well understood. Inflammatory processes and unbalance cell proliferation in the host could be behind observed correlations between a microbe and cancer stages. However, the enrichment of a microbe at a tumour site does not directly assume causation. Rather, this could be the result of a reverse causation or a confounding third factor. Therefore, two major challenges unravelling CRC aetiology are (i) to identify the mechanistic interactions of microbial communities with host intestinal epithelium cells, and (ii) to assign causality to carcinogenesis. These are the aims of this project integrating different “omic” data, and using a Mendelian randomization (MR) approach. In this study we analyse microbiome sequencing data, from up to 500 normal colon mucosa biopsies, to provide a comprehensive description of the gut microbiome. Additionally, we integrate transcriptomic data from these well phenotyped 500 samples to understand the interaction between microbes and the gut epithelial cells. Finally, using the germ-line genetic variation of host cells as a third “omic” layer, the correlations between microbes and (i) environmental exposures, (ii) gene expression, and (iii) CRC can be validated by MR. MR is an analytical approach whereby germ-line genetic markers are used as proxies – or instrumental variables – for putative risk factors. These genetic markers cannot be influenced by reverse causation, and, assuming an absence of pleiotropy, can provide unconfounded estimates of association. Therefore, a MR association between genetic proxies and the outcome of interest would indicate that the exposure being proxied is associated in a causal manner. The identification of the functional relevance and key mediators of gut microbiome to colorectal cancer development is going to increase the development of therapeutic approaches and prevention strategies.

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The information about "MECOCAM" are provided by the European Opendata Portal: CORDIS opendata.

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