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Opendata, web and dolomites

MeSoMat SIGNED

Metabolic soft matter with life-like properties

Total Cost €

EC-Contrib. €

Partnership

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MeSoMat project word cloud

Explore the words cloud of the MeSoMat project. It provides you a very rough idea of what is the project "MeSoMat" about.

time synthetic biochemical dynamic actions organisms entertain biology autonomous world equilibrium cells metabolic dynamically structurally existed realm chemistry odd unprecedented capability autonomously react man sustaining external chemical revolutionary trivial mechanical movement perform engineering reaction pattern move standard seek living tissue embryogenesis fuel first metabolism programmability life assembled biocompatibility dna capacity pioneer chosen autonomy materials loops computation self contributed construction behaviors conversations molecular robotics macroscopic embed enzyme combines kinetics difference energy community responsive create dissipate emulating biological biocompatible solutions feedback uses consuming stimuli soft drive endows endow active programming stages fundamental made

Project "MeSoMat" data sheet

The following table provides information about the project.

Coordinator	CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS Organization address address: RUE MICHEL ANGE 3 city: PARIS postcode: 75794 website: www.cnrs.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	France [FR]
Total cost	1˙899˙333 €
EC max contribution	1˙899˙333 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2017-COG
Funding Scheme	ERC-COG
Starting year	2018
Duration (year-month-day)	from 2018-06-01 to 2023-05-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS Organization address address: RUE MICHEL ANGE 3 city: PARIS postcode: 75794 website: www.cnrs.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	coordinator	1˙899˙333.00

Map

Project objective

A fundamental difference between man-made and living matter is metabolism: the ability to dissipate chemical energy to drive many different chemical processes out of equilibrium. Metabolism endows chemical systems within living organisms with properties that are standard in biology but odd in chemistry: the capability to process information, to move and to react to the external world.

My goal is to endow soft materials with dynamic life-like properties. I have chosen four: molecular computation, movement, self-construction and the capacity to entertain complex chemical conversations with living cells. To do so I will embed stimuli-responsive materials with a biocompatible synthetic metabolism capable of sustaining autonomous chemical feedback loops that process information and perform autonomous macroscopic actions. My approach combines concepts from systems chemistry, synthetic biology and DNA molecular programming with soft materials and uses a biochemical system that I have contributed to pioneer: DNA/enzyme active solutions that remain out of equilibrium by consuming a chemical fuel with non-trivial reaction kinetics. This system has three unique properties: programmability, biocompatibility and a long-term metabolic autonomy.

Metabolic matter will be assembled in two stages: i) enabling metabolic materials with dynamic chemical, biological and mechanical responses, and ii) creating metabolic materials with unprecedented properties, in particular, the capacity of self-construction, which I will seek by emulating embryogenesis, and the ability to autonomously pattern a community of living cells. By doing this I will create for the first time chemical matter that is both dynamically and structurally complex, thus bringing into the realm of synthetic chemistry behaviors that so far only existed in biological systems. In the long term, metabolic matter could provide revolutionary solutions for soft robotics and tissue engineering.

Publications

List of publications.
year	authors and title	journal	last update
2019	Anis Senoussi, Shunnichi Kashida, Raphael Voituriez, Jean-Christophe Galas, Ananyo Maitra, AndrÃ© Estevez-Torres Tunable corrugated patterns in an active nematic sheet published pages: 22464-22470, ISSN: 0027-8424, DOI: 10.1073/pnas.1912223116	Proceedings of the National Academy of Sciences 116/45	2020-01-28
2019	Georg Urtel, Marc Van Der Hofstadt, Jean-Christophe Galas, AndrÃ© Estevez-Torres rEXPAR: An Isothermal Amplification Scheme That Is Robust to Autocatalytic Parasites published pages: 2675-2681, ISSN: 0006-2960, DOI: 10.1021/acs.biochem.9b00063	Biochemistry 58/23	2020-01-28

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The information about "MESOMAT" are provided by the European Opendata Portal: CORDIS opendata.