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MeSoMat SIGNED

Metabolic soft matter with life-like properties

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 MeSoMat project word cloud

Explore the words cloud of the MeSoMat project. It provides you a very rough idea of what is the project "MeSoMat" about.

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Project "MeSoMat" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙899˙333 €
 EC max contribution 1˙899˙333 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-COG
 Funding Scheme ERC-COG
 Starting year 2018
 Duration (year-month-day) from 2018-06-01   to  2023-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 1˙899˙333.00

Map

 Project objective

A fundamental difference between man-made and living matter is metabolism: the ability to dissipate chemical energy to drive many different chemical processes out of equilibrium. Metabolism endows chemical systems within living organisms with properties that are standard in biology but odd in chemistry: the capability to process information, to move and to react to the external world.

My goal is to endow soft materials with dynamic life-like properties. I have chosen four: molecular computation, movement, self-construction and the capacity to entertain complex chemical conversations with living cells. To do so I will embed stimuli-responsive materials with a biocompatible synthetic metabolism capable of sustaining autonomous chemical feedback loops that process information and perform autonomous macroscopic actions. My approach combines concepts from systems chemistry, synthetic biology and DNA molecular programming with soft materials and uses a biochemical system that I have contributed to pioneer: DNA/enzyme active solutions that remain out of equilibrium by consuming a chemical fuel with non-trivial reaction kinetics. This system has three unique properties: programmability, biocompatibility and a long-term metabolic autonomy.

Metabolic matter will be assembled in two stages: i) enabling metabolic materials with dynamic chemical, biological and mechanical responses, and ii) creating metabolic materials with unprecedented properties, in particular, the capacity of self-construction, which I will seek by emulating embryogenesis, and the ability to autonomously pattern a community of living cells. By doing this I will create for the first time chemical matter that is both dynamically and structurally complex, thus bringing into the realm of synthetic chemistry behaviors that so far only existed in biological systems. In the long term, metabolic matter could provide revolutionary solutions for soft robotics and tissue engineering.

 Publications

year authors and title journal last update
List of publications.
2019 Anis Senoussi, Shunnichi Kashida, Raphael Voituriez, Jean-Christophe Galas, Ananyo Maitra, André Estevez-Torres
Tunable corrugated patterns in an active nematic sheet
published pages: 22464-22470, ISSN: 0027-8424, DOI: 10.1073/pnas.1912223116
Proceedings of the National Academy of Sciences 116/45 2020-01-28
2019 Georg Urtel, Marc Van Der Hofstadt, Jean-Christophe Galas, André Estevez-Torres
rEXPAR: An Isothermal Amplification Scheme That Is Robust to Autocatalytic Parasites
published pages: 2675-2681, ISSN: 0006-2960, DOI: 10.1021/acs.biochem.9b00063
Biochemistry 58/23 2020-01-28

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