Opendata, web and dolomites

PhaseControl SIGNED

How cellular suicide programmes control phase transitions in fatty liver disease and liver cancer

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 PhaseControl project word cloud

Explore the words cloud of the PhaseControl project. It provides you a very rough idea of what is the project "PhaseControl" about.

carcinoma    programmed    cell    hepatocarcinogenesis    solid    discovered    form    risk    warning    modulate    ripk3    hepatocytes    prevention    disease    steatohepatitis    initially    made    nash    liver    inflammation    indicating    networks    stage    phases    molecular    molecules    reactivity    regulate    mlkl    signs    demonstrating    alcoholic    diseases    functionally    regulatory    undergoes    chronic    genetic    critical    breaking    mutations    patients    chemoprevention    transition    serves    road    definition    decompensation    white    healthy    explore    hcc    phasecontrol    mediators    death    innovative    wat    mediate    stable    necroptosis    dependent    progression    cohort    metabolic    newly    murine    drivers    alterations    independent    ground    driver    relevance    model    examine    myeloid    hepatocellular    functions    unexpected    transitions    interact    fundamental    cancer    regulation    systematic    adipose    exploring    inflammatory    organ    cells    tissue    apoptosis    prediction    human   

Project "PhaseControl" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAETSKLINIKUM AACHEN 

Organization address
address: Pauwelsstrasse 30
city: AACHEN
postcode: 52074
website: www.ukaachen.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙997˙840 €
 EC max contribution 1˙997˙840 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-COG
 Funding Scheme ERC-COG
 Starting year 2018
 Duration (year-month-day) from 2018-11-01   to  2023-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAETSKLINIKUM AACHEN DE (AACHEN) coordinator 1˙997˙840.00

Map

 Project objective

The progression from a healthy liver towards non-alcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC) serves as a model for chronic diseases in a solid organ, demonstrating how an initially stable stage undergoes critical transitions along several defined phases. Defining the molecular drivers of these phase transitions will open the road for the definition of warning signs, risk prediction approaches and prevention of disease decompensation in human liver disease. We recently made several ground-breaking findings indicating that the molecules RIPK3 and MLKL – which regulate a novel form of programmed cell death called necroptosis – are crucial mediators of these phase transitions, but they might have unexpected and cell-death-independent functions. Therefore, PhaseControl aims at exploring the specific functions of these molecules at the critical phase transitions towards NASH/HCC. Specifically, I propose to apply a systematic approach and innovative methods to

1) explore cell-type specific RIPK3- and MLKL-dependent regulatory networks in white adipose tissue (WAT), hepatocytes and myeloid cells in murine NASH development and define cell-death independent functions of MLKL in metabolic regulation; 2) explore how inflammatory pathways in hepatocytes modulate the reactivity and specific responses towards necroptosis at the transition towards hepatocellular carcinoma (HCC); 3) examine apoptosis- and necroptosis-specific genetic alterations and driver mutations that mediate the transition from chronic inflammation to HCC; 4) evaluate in a cohort of human patients if these newly discovered pathways can be used for risk-prediction approaches and might be chemoprevention targets against HCC.

The expected results will establish a novel concept how programmed cell death, inflammation and metabolic pathways functionally interact in hepatocarcinogenesis with fundamental relevance for risk prediction and chemoprevention of human liver cancer.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "PHASECONTROL" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "PHASECONTROL" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

Aware (2019)

Aiding Antibiotic Development with Deep Analysis of Resistance Evolution

Read More  

OSIRIS (2020)

Automatic measurement of speech understanding using EEG

Read More  

ENUF (2019)

Evaluation of Novel Ultra-Fast selective III-V Epitaxy

Read More