Opendata, web and dolomites

ICEBERG SIGNED

Exploration below the tip of the microtubule

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 ICEBERG project word cloud

Explore the words cloud of the ICEBERG project. It provides you a very rough idea of what is the project "ICEBERG" about.

hidden    instability    contrast    motors    self    discovery    supporting    confers    structure    mt    interphase    hypothesise    vista    exploring    feedback    repair    mts    architecture    physiological    opens    removal    permanently    tubulin    entire    sites    protect    recruitment    organisation    intracellular    dynamic    boundary    incorporations    cells    modifying    rules    cytoplasmic    reconstituted    mechanical    network    molecular    lattice    passive    directing    recruitments    filaments    famous    architectures    vitro    spatial    mechano    anticipate    regulates    networks    functions    local    microtubules    enzymes    stiffness    propagation    turnover    cytoskeleton    depolymerisation    exchanged    biology    reformulate    pool    microfabricated    unexpected    length    found    shape    cultured    governed    damaged    transport    life    sensory    possibly    tips    relevance    shrinkage    plasticity    biophysical    regulate    span    mechanism    forces    biochemical    dimers    90    regulating    transit    maps    active    iceberg    first    actually    mechanically    tip    mechanisms   

Project "ICEBERG" data sheet

The following table provides information about the project.

Coordinator
COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES 

Organization address
address: RUE LEBLANC 25
city: PARIS 15
postcode: 75015
website: www.cea.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙998˙227 €
 EC max contribution 1˙998˙227 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-COG
 Funding Scheme ERC-COG
 Starting year 2018
 Duration (year-month-day) from 2018-10-01   to  2023-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES FR (PARIS 15) coordinator 1˙998˙227.00

Map

 Project objective

Microtubules (MTs) are dynamic cytoskeleton filaments. They permanently transit between growth and shrinkage. This famous “dynamic instability” is governed by the addition and loss of tubulin dimers at their tips. In contrast to the tip, the MT lattice was considered to be a passive structure supporting intracellular transport. However, we recently found that MT lattice is dynamic and active! Actually, tubulin dimers can be exchanged with the cytoplasmic pool along the entire length of the MT. These incorporations can repair sites on the lattice that have been mechanically damaged. These repair sites protect the MTs from depolymerisation and increase the MT’s life span. This discovery opens up a new vista for understanding MT biology. First, we will investigate the biochemical consequences of MT-lattice turnover. We hypothesise that tubulin turnover affects the recruitment of MAPs, motors and tubulin-modifying enzymes. These recruitments may feedback on lattice turnover and further regulate MT life span and functions. Second, we will investigate the mechanical impact of the MT-lattice plasticity. Tubulin removal is likely to be associated with a local reduction of MT stiffness that can impact MT shape and the propagation of forces along the lattice. We anticipate that such effects will require us to reformulate the biophysical rules directing network architecture. To achieve this, we will use reconstituted MT networks in vitro to investigate the molecular mechanism regulating MT-lattice plasticity, and cultured cells to test the physiological relevance of these mechanisms. In both approaches, microfabricated devices will be used to control the spatial boundary conditions directing MT self-organisation. By exploring the hidden 90% of MT iceberg we aim to show that the MT lattice is a dynamic mechano-sensory structure which regulates interphase MT-network architectures and possibly confers them unexpected functions.

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The information about "ICEBERG" are provided by the European Opendata Portal: CORDIS opendata.

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