Opendata, web and dolomites

ICEBERG SIGNED

Exploration below the tip of the microtubule

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 ICEBERG project word cloud

Explore the words cloud of the ICEBERG project. It provides you a very rough idea of what is the project "ICEBERG" about.

instability    hypothesise    biophysical    supporting    regulate    shape    length    directing    incorporations    active    tips    reconstituted    stiffness    microtubules    physiological    opens    repair    architecture    vitro    network    networks    regulates    biology    sensory    feedback    sites    anticipate    motors    enzymes    transit    organisation    mechanically    regulating    permanently    recruitments    rules    actually    filaments    shrinkage    governed    microfabricated    cells    cytoplasmic    possibly    mechanical    modifying    tip    exploring    functions    cultured    forces    transport    contrast    depolymerisation    mt    relevance    life    span    mechanism    hidden    90    confers    mechano    tubulin    dimers    lattice    reformulate    maps    passive    molecular    intracellular    exchanged    found    recruitment    iceberg    pool    plasticity    unexpected    biochemical    local    mechanisms    structure    first    protect    vista    spatial    boundary    turnover    propagation    architectures    discovery    entire    mts    cytoskeleton    self    removal    famous    interphase    dynamic    damaged   

Project "ICEBERG" data sheet

The following table provides information about the project.

Coordinator
COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES 

Organization address
address: RUE LEBLANC 25
city: PARIS 15
postcode: 75015
website: www.cea.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙998˙227 €
 EC max contribution 1˙998˙227 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-COG
 Funding Scheme ERC-COG
 Starting year 2018
 Duration (year-month-day) from 2018-10-01   to  2023-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES FR (PARIS 15) coordinator 1˙998˙227.00

Map

Leaflet | Map data © OpenStreetMap contributors, CC-BY-SA, Imagery © Mapbox

 Project objective

Microtubules (MTs) are dynamic cytoskeleton filaments. They permanently transit between growth and shrinkage. This famous “dynamic instability” is governed by the addition and loss of tubulin dimers at their tips. In contrast to the tip, the MT lattice was considered to be a passive structure supporting intracellular transport. However, we recently found that MT lattice is dynamic and active! Actually, tubulin dimers can be exchanged with the cytoplasmic pool along the entire length of the MT. These incorporations can repair sites on the lattice that have been mechanically damaged. These repair sites protect the MTs from depolymerisation and increase the MT’s life span. This discovery opens up a new vista for understanding MT biology. First, we will investigate the biochemical consequences of MT-lattice turnover. We hypothesise that tubulin turnover affects the recruitment of MAPs, motors and tubulin-modifying enzymes. These recruitments may feedback on lattice turnover and further regulate MT life span and functions. Second, we will investigate the mechanical impact of the MT-lattice plasticity. Tubulin removal is likely to be associated with a local reduction of MT stiffness that can impact MT shape and the propagation of forces along the lattice. We anticipate that such effects will require us to reformulate the biophysical rules directing network architecture. To achieve this, we will use reconstituted MT networks in vitro to investigate the molecular mechanism regulating MT-lattice plasticity, and cultured cells to test the physiological relevance of these mechanisms. In both approaches, microfabricated devices will be used to control the spatial boundary conditions directing MT self-organisation. By exploring the hidden 90% of MT iceberg we aim to show that the MT lattice is a dynamic mechano-sensory structure which regulates interphase MT-network architectures and possibly confers them unexpected functions.

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The information about "ICEBERG" are provided by the European Opendata Portal: CORDIS opendata.

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