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Click-It SIGNED

“In Vivo Click PET Imaging Agents”: Improving clinical companion diagnostics

Total Cost €

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EC-Contrib. €

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Partnership

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 Click-It project word cloud

Explore the words cloud of the Click-It project. It provides you a very rough idea of what is the project "Click-It" about.

limited    patient    lower    issue    diagnostics    circumvent    small    drawbacks    date    multiple    superior    ligation    companion    radiation    generally    intracellular    resolution    boost    scope    time    compatible    internalizing    planning    exhibit    drug    accessible    monitoring    lived    antibodies    contrast    blood    pharmacokinetics    pretargeted    turn    spect    xenograft    leads    demonstrated    points    nuclides    absorbed    therapy    administration    radiolabeled    offers    probe    pet    agents    translate    tagged    temporal    imaging    molecule    majority    centers    shown    quantitative    clinically    diagnosis    vivo    repeated    metal    optimal    ratios    pretargeting    tag    snapshots    pdx    tracers    isotopes    fast    binding    models    retention    internalize    mouse    fastest    click    disease    routine    expanding    nanomedicine    expand    18f    reaction    proven    regard    molecules    clearing    spatial    applicable    doses    slow    scan    decision    precluding    tetrazine    followed    nuclear    nanomedicines   

Project "Click-It" data sheet

The following table provides information about the project.

Coordinator
REGION HOVEDSTADEN 

Organization address
address: KONGENS VAENGE 2
city: HILLEROD
postcode: 3400
website: www.regionh.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Project website http://click-it-imaging.eu/index.html
 Total cost 5˙999˙800 €
 EC max contribution 5˙999˙800 € (100%)
 Programme 1. H2020-EU.3.1.3. (Treating and managing disease)
 Code Call H2020-PHC-2015-two-stage
 Funding Scheme RIA
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2020-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    REGION HOVEDSTADEN DK (HILLEROD) coordinator 2˙160˙000.00
2    TAGWORKS PHARMACEUTICALS BV NL (Eindhoven) participant 1˙560˙000.00
3    TECHNISCHE UNIVERSITAET WIEN AT (WIEN) participant 829˙600.00
4    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) participant 600˙000.00
5    AIT AUSTRIAN INSTITUTE OF TECHNOLOGY GMBH AT (WIEN) participant 550˙200.00
6    JOHANNES GUTENBERG-UNIVERSITAT MAINZ DE (MAINZ) participant 300˙000.00

Map

 Project objective

Companion diagnostics are crucial for drug development and disease management with regard to patient selection, therapy planning and monitoring. Nanomedicines such as antibodies have been proven to be optimal disease-targeting agents because they generally exhibit superior target uptake and retention. However, to date, nuclear imaging of nanomedicines has been limited to the use of long-lived isotopes to be compatible with the slow pharmacokinetics of these large molecules. Major drawbacks are high radiation doses, precluding routine and repeated companion imaging procedures. The Click-It consortium aims to circumvent this issue by using pretargeting approach, which centers on the administration and target binding of a tagged nanomedicine followed by administration and binding of a small, fast-clearing, short-lived radiolabeled probe to the tag of the nanomedicine. This results in lower absorbed radiation doses and in a boost in target-blood ratios, which in turn leads to a superior imaging contrast. PET scan snapshots at multiple time-points provide long-term imaging information by applying short-lived nuclides. So far, only the fastest click reaction, the tetrazine ligation, has demonstrated potential in clinically relevant conditions. Recently, we have shown in a SPECT imaging study that this click reaction can be applied for non-internalizing nanomedicines in vivo. This project aims at expanding the scope of click-pretargeted imaging to intracellular targets, because a majority of nanomedicines internalize and is thus not accessible with the current approach. Furthermore, we will expand our approach to short-lived, non-metal based, small molecule 18F-PET tracers, since PET offers a higher spatial and temporal resolution enabling quantitative decision making in disease diagnosis and management. Finally, the project aims to translate the developed click-pretargeting technology into a clinically applicable nanomedicine-based imaging approach in relevant patient-derived xenograft (PDX) mouse models.

 Deliverables

List of deliverables.
Webpage Websites, patent fillings, videos etc. 2020-01-29 12:38:23

Take a look to the deliverables list in detail:  detailed list of Click-It deliverables.

 Publications

year authors and title journal last update
List of publications.
2019 Christoph Denk, Martin Wilkovitsch, Emma Aneheim, Matthias Herth, Holger Jensen, Sture Lindegren, Hannes Mikula
Multifunctional clickable reagents for rapid bioorthogonal astatination and radio-crosslinking
published pages: , ISSN: 2192-6506, DOI: 10.1002/cplu.201900114
ChemPlusChem 2020-01-29
2019 Veronika Rosecker, Christoph Denk, Melanie Maurer, Martin Wilkovitsch, Severin Mairinger, Thomas Wanek, Hannes Mikula
Cross-Isotopic Bioorthogonal Tools as Molecular Twins for Radiotheranostic Applications
published pages: , ISSN: 1439-4227, DOI: 10.1002/cbic.201900042
ChemBioChem 2020-01-29
2018 E. Johanna L. Stéen, Patricia E. Edem, Kamilla Nørregaard, Jesper T. Jørgensen, Vladimir Shalgunov, Andreas Kjaer, Matthias M. Herth
Pretargeting in nuclear imaging and radionuclide therapy: Improving efficacy of theranostics and nanomedicines
published pages: 209-245, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2018.06.021
Biomaterials 179 2020-01-29
2018 E. Johanna L. Stéen, Vladimir Shalgunov, Christoph Denk, Hannes Mikula, Andreas Kjaer, Jesper L. Kristensen, Matthias M. Herth
Convenient Entry to 18 F-Labeled Amines through the Staudinger Reduction
published pages: , ISSN: 1434-193X, DOI: 10.1002/ejoc.201801457
European Journal of Organic Chemistry 2020-01-29
2018 Dennis Svatunek, Christoph Denk, Hannes Mikula
A computational model to predict the Diels–Alder reactivity of aryl/alkyl-substituted tetrazines
published pages: 833-837, ISSN: 0026-9247, DOI: 10.1007/s00706-017-2110-x
Monatshefte für Chemie - Chemical Monthly 149/4 2020-01-29

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The information about "CLICK-IT" are provided by the European Opendata Portal: CORDIS opendata.

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