Explore the words cloud of the Click-It project. It provides you a very rough idea of what is the project "Click-It" about.
The following table provides information about the project.
|Coordinator Country||Denmark [DK]|
|Total cost||5˙999˙800 €|
|EC max contribution||5˙999˙800 € (100%)|
1. H2020-EU.3.1.3. (Treating and managing disease)
|Duration (year-month-day)||from 2016-01-01 to 2020-12-31|
Take a look of project's partnership.
|1||REGION HOVEDSTADEN||DK (HILLEROD)||coordinator||2˙160˙000.00|
|2||TAGWORKS PHARMACEUTICALS BV||NL (Eindhoven)||participant||1˙560˙000.00|
|3||TECHNISCHE UNIVERSITAET WIEN||AT (WIEN)||participant||829˙600.00|
|4||KOBENHAVNS UNIVERSITET||DK (KOBENHAVN)||participant||600˙000.00|
|5||AIT AUSTRIAN INSTITUTE OF TECHNOLOGY GMBH||AT (WIEN)||participant||550˙200.00|
|6||JOHANNES GUTENBERG-UNIVERSITAT MAINZ||DE (MAINZ)||participant||300˙000.00|
Companion diagnostics are crucial for drug development and disease management with regard to patient selection, therapy planning and monitoring. Nanomedicines such as antibodies have been proven to be optimal disease-targeting agents because they generally exhibit superior target uptake and retention. However, to date, nuclear imaging of nanomedicines has been limited to the use of long-lived isotopes to be compatible with the slow pharmacokinetics of these large molecules. Major drawbacks are high radiation doses, precluding routine and repeated companion imaging procedures. The Click-It consortium aims to circumvent this issue by using pretargeting approach, which centers on the administration and target binding of a tagged nanomedicine followed by administration and binding of a small, fast-clearing, short-lived radiolabeled probe to the tag of the nanomedicine. This results in lower absorbed radiation doses and in a boost in target-blood ratios, which in turn leads to a superior imaging contrast. PET scan snapshots at multiple time-points provide long-term imaging information by applying short-lived nuclides. So far, only the fastest click reaction, the tetrazine ligation, has demonstrated potential in clinically relevant conditions. Recently, we have shown in a SPECT imaging study that this click reaction can be applied for non-internalizing nanomedicines in vivo. This project aims at expanding the scope of click-pretargeted imaging to intracellular targets, because a majority of nanomedicines internalize and is thus not accessible with the current approach. Furthermore, we will expand our approach to short-lived, non-metal based, small molecule 18F-PET tracers, since PET offers a higher spatial and temporal resolution enabling quantitative decision making in disease diagnosis and management. Finally, the project aims to translate the developed click-pretargeting technology into a clinically applicable nanomedicine-based imaging approach in relevant patient-derived xenograft (PDX) mouse models.
|Webpage||Websites, patent fillings, videos etc.||2020-01-29 12:38:23|
Take a look to the deliverables list in detail: detailed list of Click-It deliverables.
|year||authors and title||journal||last update|
Christoph Denk, Martin Wilkovitsch, Emma Aneheim, Matthias Herth, Holger Jensen, Sture Lindegren, Hannes Mikula
Multifunctional clickable reagents for rapid bioorthogonal astatination and radio-crosslinking
published pages: , ISSN: 2192-6506, DOI: 10.1002/cplu.201900114
Veronika Rosecker, Christoph Denk, Melanie Maurer, Martin Wilkovitsch, Severin Mairinger, Thomas Wanek, Hannes Mikula
Cross-Isotopic Bioorthogonal Tools as Molecular Twins for Radiotheranostic Applications
published pages: , ISSN: 1439-4227, DOI: 10.1002/cbic.201900042
E. Johanna L. StÃ©en, Patricia E. Edem, Kamilla NÃ¸rregaard, Jesper T. JÃ¸rgensen, Vladimir Shalgunov, Andreas Kjaer, Matthias M. Herth
Pretargeting in nuclear imaging and radionuclide therapy: Improving efficacy of theranostics and nanomedicines
published pages: 209-245, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2018.06.021
E. Johanna L. StÃ©en, Vladimir Shalgunov, Christoph Denk, Hannes Mikula, Andreas Kjaer, Jesper L. Kristensen, Matthias M. Herth
Convenient Entry to 18 F-Labeled Amines through the Staudinger Reduction
published pages: , ISSN: 1434-193X, DOI: 10.1002/ejoc.201801457
|European Journal of Organic Chemistry||2020-01-29|
Dennis Svatunek, Christoph Denk, Hannes Mikula
A computational model to predict the Dielsâ€“Alder reactivity of aryl/alkyl-substituted tetrazines
published pages: 833-837, ISSN: 0026-9247, DOI: 10.1007/s00706-017-2110-x
|Monatshefte fÃ¼r Chemie - Chemical Monthly 149/4||2020-01-29|
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The information about "CLICK-IT" are provided by the European Opendata Portal: CORDIS opendata.
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