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Click-It SIGNED

“In Vivo Click PET Imaging Agents”: Improving clinical companion diagnostics

Total Cost €

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EC-Contrib. €

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Partnership

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 Click-It project word cloud

Explore the words cloud of the Click-It project. It provides you a very rough idea of what is the project "Click-It" about.

repeated    diagnosis    clearing    spatial    majority    fastest    leads    nanomedicines    precluding    tag    reaction    binding    spect    antibodies    expanding    expand    patient    administration    drug    drawbacks    scan    monitoring    isotopes    tracers    models    vivo    tagged    diagnostics    lower    blood    offers    pretargeted    nanomedicine    translate    nuclear    exhibit    limited    molecule    disease    agents    regard    generally    pretargeting    quantitative    circumvent    centers    xenograft    imaging    small    ligation    decision    click    superior    tetrazine    doses    pdx    time    internalizing    scope    accessible    multiple    resolution    ratios    planning    demonstrated    internalize    applicable    probe    radiolabeled    18f    points    snapshots    therapy    radiation    followed    boost    slow    compatible    lived    intracellular    date    pharmacokinetics    shown    routine    pet    nuclides    companion    turn    contrast    clinically    optimal    issue    mouse    molecules    absorbed    metal    fast    proven    retention    temporal   

Project "Click-It" data sheet

The following table provides information about the project.

Coordinator
REGION HOVEDSTADEN 

Organization address
address: KONGENS VAENGE 2
city: HILLEROD
postcode: 3400
website: www.regionh.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Project website http://click-it-imaging.eu/index.html
 Total cost 5˙999˙800 €
 EC max contribution 5˙999˙800 € (100%)
 Programme 1. H2020-EU.3.1.3. (Treating and managing disease)
 Code Call H2020-PHC-2015-two-stage
 Funding Scheme RIA
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2020-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    REGION HOVEDSTADEN DK (HILLEROD) coordinator 2˙160˙000.00
2    TAGWORKS PHARMACEUTICALS BV NL (Eindhoven) participant 1˙560˙000.00
3    TECHNISCHE UNIVERSITAET WIEN AT (WIEN) participant 829˙600.00
4    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) participant 600˙000.00
5    AIT AUSTRIAN INSTITUTE OF TECHNOLOGY GMBH AT (WIEN) participant 550˙200.00
6    JOHANNES GUTENBERG-UNIVERSITAT MAINZ DE (MAINZ) participant 300˙000.00

Map

 Project objective

Companion diagnostics are crucial for drug development and disease management with regard to patient selection, therapy planning and monitoring. Nanomedicines such as antibodies have been proven to be optimal disease-targeting agents because they generally exhibit superior target uptake and retention. However, to date, nuclear imaging of nanomedicines has been limited to the use of long-lived isotopes to be compatible with the slow pharmacokinetics of these large molecules. Major drawbacks are high radiation doses, precluding routine and repeated companion imaging procedures. The Click-It consortium aims to circumvent this issue by using pretargeting approach, which centers on the administration and target binding of a tagged nanomedicine followed by administration and binding of a small, fast-clearing, short-lived radiolabeled probe to the tag of the nanomedicine. This results in lower absorbed radiation doses and in a boost in target-blood ratios, which in turn leads to a superior imaging contrast. PET scan snapshots at multiple time-points provide long-term imaging information by applying short-lived nuclides. So far, only the fastest click reaction, the tetrazine ligation, has demonstrated potential in clinically relevant conditions. Recently, we have shown in a SPECT imaging study that this click reaction can be applied for non-internalizing nanomedicines in vivo. This project aims at expanding the scope of click-pretargeted imaging to intracellular targets, because a majority of nanomedicines internalize and is thus not accessible with the current approach. Furthermore, we will expand our approach to short-lived, non-metal based, small molecule 18F-PET tracers, since PET offers a higher spatial and temporal resolution enabling quantitative decision making in disease diagnosis and management. Finally, the project aims to translate the developed click-pretargeting technology into a clinically applicable nanomedicine-based imaging approach in relevant patient-derived xenograft (PDX) mouse models.

 Deliverables

List of deliverables.
Webpage Websites, patent fillings, videos etc. 2020-01-29 12:38:23

Take a look to the deliverables list in detail:  detailed list of Click-It deliverables.

 Publications

year authors and title journal last update
List of publications.
2019 Christoph Denk, Martin Wilkovitsch, Emma Aneheim, Matthias Herth, Holger Jensen, Sture Lindegren, Hannes Mikula
Multifunctional clickable reagents for rapid bioorthogonal astatination and radio-crosslinking
published pages: , ISSN: 2192-6506, DOI: 10.1002/cplu.201900114
ChemPlusChem 2020-01-29
2019 Veronika Rosecker, Christoph Denk, Melanie Maurer, Martin Wilkovitsch, Severin Mairinger, Thomas Wanek, Hannes Mikula
Cross-Isotopic Bioorthogonal Tools as Molecular Twins for Radiotheranostic Applications
published pages: , ISSN: 1439-4227, DOI: 10.1002/cbic.201900042
ChemBioChem 2020-01-29
2018 E. Johanna L. Stéen, Patricia E. Edem, Kamilla Nørregaard, Jesper T. Jørgensen, Vladimir Shalgunov, Andreas Kjaer, Matthias M. Herth
Pretargeting in nuclear imaging and radionuclide therapy: Improving efficacy of theranostics and nanomedicines
published pages: 209-245, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2018.06.021
Biomaterials 179 2020-01-29
2018 E. Johanna L. Stéen, Vladimir Shalgunov, Christoph Denk, Hannes Mikula, Andreas Kjaer, Jesper L. Kristensen, Matthias M. Herth
Convenient Entry to 18 F-Labeled Amines through the Staudinger Reduction
published pages: , ISSN: 1434-193X, DOI: 10.1002/ejoc.201801457
European Journal of Organic Chemistry 2020-01-29
2018 Dennis Svatunek, Christoph Denk, Hannes Mikula
A computational model to predict the Diels–Alder reactivity of aryl/alkyl-substituted tetrazines
published pages: 833-837, ISSN: 0026-9247, DOI: 10.1007/s00706-017-2110-x
Monatshefte für Chemie - Chemical Monthly 149/4 2020-01-29

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The information about "CLICK-IT" are provided by the European Opendata Portal: CORDIS opendata.

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