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“In Vivo Click PET Imaging Agents”: Improving clinical companion diagnostics

Total Cost €


EC-Contrib. €






 Click-It project word cloud

Explore the words cloud of the Click-It project. It provides you a very rough idea of what is the project "Click-It" about.

nanomedicine    patient    monitoring    small    molecule    retention    pretargeting    temporal    proven    centers    18f    accessible    routine    nanomedicines    drug    therapy    planning    tetrazine    multiple    ligation    expanding    internalizing    lower    snapshots    reaction    models    nuclides    tracers    compatible    ratios    vivo    diagnosis    points    lived    scope    circumvent    translate    majority    demonstrated    turn    absorbed    administration    drawbacks    antibodies    generally    boost    exhibit    contrast    internalize    spect    leads    diagnostics    fast    time    click    issue    pdx    tag    blood    imaging    mouse    repeated    nuclear    pretargeted    quantitative    binding    probe    agents    limited    clearing    xenograft    pet    doses    fastest    intracellular    expand    molecules    pharmacokinetics    radiation    followed    superior    scan    offers    regard    precluding    companion    clinically    date    applicable    radiolabeled    tagged    metal    shown    disease    slow    optimal    isotopes    spatial    decision    resolution   

Project "Click-It" data sheet

The following table provides information about the project.


Organization address
postcode: 3400

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Project website
 Total cost 5˙999˙800 €
 EC max contribution 5˙999˙800 € (100%)
 Programme 1. H2020-EU.3.1.3. (Treating and managing disease)
 Code Call H2020-PHC-2015-two-stage
 Funding Scheme RIA
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2020-12-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    REGION HOVEDSTADEN DK (HILLEROD) coordinator 2˙160˙000.00
2    TAGWORKS PHARMACEUTICALS BV NL (Eindhoven) participant 1˙560˙000.00
3    TECHNISCHE UNIVERSITAET WIEN AT (WIEN) participant 829˙600.00
4    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) participant 600˙000.00


 Project objective

Companion diagnostics are crucial for drug development and disease management with regard to patient selection, therapy planning and monitoring. Nanomedicines such as antibodies have been proven to be optimal disease-targeting agents because they generally exhibit superior target uptake and retention. However, to date, nuclear imaging of nanomedicines has been limited to the use of long-lived isotopes to be compatible with the slow pharmacokinetics of these large molecules. Major drawbacks are high radiation doses, precluding routine and repeated companion imaging procedures. The Click-It consortium aims to circumvent this issue by using pretargeting approach, which centers on the administration and target binding of a tagged nanomedicine followed by administration and binding of a small, fast-clearing, short-lived radiolabeled probe to the tag of the nanomedicine. This results in lower absorbed radiation doses and in a boost in target-blood ratios, which in turn leads to a superior imaging contrast. PET scan snapshots at multiple time-points provide long-term imaging information by applying short-lived nuclides. So far, only the fastest click reaction, the tetrazine ligation, has demonstrated potential in clinically relevant conditions. Recently, we have shown in a SPECT imaging study that this click reaction can be applied for non-internalizing nanomedicines in vivo. This project aims at expanding the scope of click-pretargeted imaging to intracellular targets, because a majority of nanomedicines internalize and is thus not accessible with the current approach. Furthermore, we will expand our approach to short-lived, non-metal based, small molecule 18F-PET tracers, since PET offers a higher spatial and temporal resolution enabling quantitative decision making in disease diagnosis and management. Finally, the project aims to translate the developed click-pretargeting technology into a clinically applicable nanomedicine-based imaging approach in relevant patient-derived xenograft (PDX) mouse models.


List of deliverables.
Webpage Websites, patent fillings, videos etc. 2020-01-29 12:38:23

Take a look to the deliverables list in detail:  detailed list of Click-It deliverables.


year authors and title journal last update
List of publications.
2019 Christoph Denk, Martin Wilkovitsch, Emma Aneheim, Matthias Herth, Holger Jensen, Sture Lindegren, Hannes Mikula
Multifunctional clickable reagents for rapid bioorthogonal astatination and radio-crosslinking
published pages: , ISSN: 2192-6506, DOI: 10.1002/cplu.201900114
ChemPlusChem 2020-01-29
2019 Veronika Rosecker, Christoph Denk, Melanie Maurer, Martin Wilkovitsch, Severin Mairinger, Thomas Wanek, Hannes Mikula
Cross-Isotopic Bioorthogonal Tools as Molecular Twins for Radiotheranostic Applications
published pages: , ISSN: 1439-4227, DOI: 10.1002/cbic.201900042
ChemBioChem 2020-01-29
2018 E. Johanna L. Stéen, Patricia E. Edem, Kamilla Nørregaard, Jesper T. Jørgensen, Vladimir Shalgunov, Andreas Kjaer, Matthias M. Herth
Pretargeting in nuclear imaging and radionuclide therapy: Improving efficacy of theranostics and nanomedicines
published pages: 209-245, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2018.06.021
Biomaterials 179 2020-01-29
2018 E. Johanna L. Stéen, Vladimir Shalgunov, Christoph Denk, Hannes Mikula, Andreas Kjaer, Jesper L. Kristensen, Matthias M. Herth
Convenient Entry to 18 F-Labeled Amines through the Staudinger Reduction
published pages: , ISSN: 1434-193X, DOI: 10.1002/ejoc.201801457
European Journal of Organic Chemistry 2020-01-29
2018 Dennis Svatunek, Christoph Denk, Hannes Mikula
A computational model to predict the Diels–Alder reactivity of aryl/alkyl-substituted tetrazines
published pages: 833-837, ISSN: 0026-9247, DOI: 10.1007/s00706-017-2110-x
Monatshefte für Chemie - Chemical Monthly 149/4 2020-01-29

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The information about "CLICK-IT" are provided by the European Opendata Portal: CORDIS opendata.

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