Explore the words cloud of the Click-It project. It provides you a very rough idea of what is the project "Click-It" about.
The following table provides information about the project.
|Coordinator Country||Denmark [DK]|
|Total cost||5˙999˙800 €|
|EC max contribution||5˙999˙800 € (100%)|
1. H2020-EU.3.1. (SOCIETAL CHALLENGES - Health, demographic change and well-being)
|Duration (year-month-day)||from 2016-01-01 to 2020-12-31|
Take a look of project's partnership.
|1||REGION HOVEDSTADEN||DK (HILLEROD)||coordinator||2˙160˙000.00|
|2||TAGWORKS PHARMACEUTICALS BV||NL (Eindhoven)||participant||1˙560˙000.00|
|3||TECHNISCHE UNIVERSITAET WIEN||AT (WIEN)||participant||829˙600.00|
|4||KOBENHAVNS UNIVERSITET||DK (KOBENHAVN)||participant||600˙000.00|
|5||AIT AUSTRIAN INSTITUTE OF TECHNOLOGY GMBH||AT (WIEN)||participant||550˙200.00|
|6||JOHANNES GUTENBERG-UNIVERSITAT MAINZ||DE (MAINZ)||participant||300˙000.00|
Companion diagnostics are crucial for drug development and disease management with regard to patient selection, therapy planning and monitoring. Nanomedicines such as antibodies have been proven to be optimal disease-targeting agents because they generally exhibit superior target uptake and retention. However, to date, nuclear imaging of nanomedicines has been limited to the use of long-lived isotopes to be compatible with the slow pharmacokinetics of these large molecules. Major drawbacks are high radiation doses, precluding routine and repeated companion imaging procedures. The Click-It consortium aims to circumvent this issue by using pretargeting approach, which centers on the administration and target binding of a tagged nanomedicine followed by administration and binding of a small, fast-clearing, short-lived radiolabeled probe to the tag of the nanomedicine. This results in lower absorbed radiation doses and in a boost in target-blood ratios, which in turn leads to a superior imaging contrast. PET scan snapshots at multiple time-points provide long-term imaging information by applying short-lived nuclides. So far, only the fastest click reaction, the tetrazine ligation, has demonstrated potential in clinically relevant conditions. Recently, we have shown in a SPECT imaging study that this click reaction can be applied for non-internalizing nanomedicines in vivo. This project aims at expanding the scope of click-pretargeted imaging to intracellular targets, because a majority of nanomedicines internalize and is thus not accessible with the current approach. Furthermore, we will expand our approach to short-lived, non-metal based, small molecule 18F-PET tracers, since PET offers a higher spatial and temporal resolution enabling quantitative decision making in disease diagnosis and management. Finally, the project aims to translate the developed click-pretargeting technology into a clinically applicable nanomedicine-based imaging approach in canine patients.
Work performed, outcomes and results: advancements report(s)
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The information about "CLICK-IT" are provided by the European Opendata Portal: CORDIS opendata.