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Click-It SIGNED

“In Vivo Click PET Imaging Agents”: Improving clinical companion diagnostics

Total Cost €

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EC-Contrib. €

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Partnership

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 Click-It project word cloud

Explore the words cloud of the Click-It project. It provides you a very rough idea of what is the project "Click-It" about.

exhibit    planning    pet    expand    nuclides    probe    tag    nanomedicine    routine    leads    translate    pharmacokinetics    spect    circumvent    lived    turn    absorbed    metal    majority    applicable    offers    pretargeted    therapy    spatial    tagged    scope    administration    diagnostics    followed    isotopes    proven    repeated    nanomedicines    accessible    internalizing    click    molecule    superior    boost    companion    compatible    monitoring    optimal    radiation    doses    limited    patient    vivo    precluding    clearing    drawbacks    molecules    tetrazine    demonstrated    18f    fastest    ligation    quantitative    reaction    diagnosis    clinically    models    disease    fast    blood    resolution    xenograft    radiolabeled    internalize    shown    points    temporal    antibodies    contrast    centers    snapshots    regard    ratios    agents    nuclear    intracellular    imaging    pretargeting    time    date    expanding    small    pdx    tracers    multiple    generally    decision    issue    lower    drug    retention    mouse    slow    binding    scan   

Project "Click-It" data sheet

The following table provides information about the project.

Coordinator
REGION HOVEDSTADEN 

Organization address
address: KONGENS VAENGE 2
city: HILLEROD
postcode: 3400
website: www.regionh.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Project website http://click-it-imaging.eu/index.html
 Total cost 5˙999˙800 €
 EC max contribution 5˙999˙800 € (100%)
 Programme 1. H2020-EU.3.1.3. (Treating and managing disease)
 Code Call H2020-PHC-2015-two-stage
 Funding Scheme RIA
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2020-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    REGION HOVEDSTADEN DK (HILLEROD) coordinator 2˙160˙000.00
2    TAGWORKS PHARMACEUTICALS BV NL (Eindhoven) participant 1˙560˙000.00
3    TECHNISCHE UNIVERSITAET WIEN AT (WIEN) participant 829˙600.00
4    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) participant 600˙000.00
5    AIT AUSTRIAN INSTITUTE OF TECHNOLOGY GMBH AT (WIEN) participant 550˙200.00
6    JOHANNES GUTENBERG-UNIVERSITAT MAINZ DE (MAINZ) participant 300˙000.00

Map

 Project objective

Companion diagnostics are crucial for drug development and disease management with regard to patient selection, therapy planning and monitoring. Nanomedicines such as antibodies have been proven to be optimal disease-targeting agents because they generally exhibit superior target uptake and retention. However, to date, nuclear imaging of nanomedicines has been limited to the use of long-lived isotopes to be compatible with the slow pharmacokinetics of these large molecules. Major drawbacks are high radiation doses, precluding routine and repeated companion imaging procedures. The Click-It consortium aims to circumvent this issue by using pretargeting approach, which centers on the administration and target binding of a tagged nanomedicine followed by administration and binding of a small, fast-clearing, short-lived radiolabeled probe to the tag of the nanomedicine. This results in lower absorbed radiation doses and in a boost in target-blood ratios, which in turn leads to a superior imaging contrast. PET scan snapshots at multiple time-points provide long-term imaging information by applying short-lived nuclides. So far, only the fastest click reaction, the tetrazine ligation, has demonstrated potential in clinically relevant conditions. Recently, we have shown in a SPECT imaging study that this click reaction can be applied for non-internalizing nanomedicines in vivo. This project aims at expanding the scope of click-pretargeted imaging to intracellular targets, because a majority of nanomedicines internalize and is thus not accessible with the current approach. Furthermore, we will expand our approach to short-lived, non-metal based, small molecule 18F-PET tracers, since PET offers a higher spatial and temporal resolution enabling quantitative decision making in disease diagnosis and management. Finally, the project aims to translate the developed click-pretargeting technology into a clinically applicable nanomedicine-based imaging approach in relevant patient-derived xenograft (PDX) mouse models.

 Deliverables

List of deliverables.
Webpage Websites, patent fillings, videos etc. 2020-01-29 12:38:23

Take a look to the deliverables list in detail:  detailed list of Click-It deliverables.

 Publications

year authors and title journal last update
List of publications.
2019 Christoph Denk, Martin Wilkovitsch, Emma Aneheim, Matthias Herth, Holger Jensen, Sture Lindegren, Hannes Mikula
Multifunctional clickable reagents for rapid bioorthogonal astatination and radio-crosslinking
published pages: , ISSN: 2192-6506, DOI: 10.1002/cplu.201900114
ChemPlusChem 2020-01-29
2019 Veronika Rosecker, Christoph Denk, Melanie Maurer, Martin Wilkovitsch, Severin Mairinger, Thomas Wanek, Hannes Mikula
Cross-Isotopic Bioorthogonal Tools as Molecular Twins for Radiotheranostic Applications
published pages: , ISSN: 1439-4227, DOI: 10.1002/cbic.201900042
ChemBioChem 2020-01-29
2018 E. Johanna L. Stéen, Patricia E. Edem, Kamilla Nørregaard, Jesper T. Jørgensen, Vladimir Shalgunov, Andreas Kjaer, Matthias M. Herth
Pretargeting in nuclear imaging and radionuclide therapy: Improving efficacy of theranostics and nanomedicines
published pages: 209-245, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2018.06.021
Biomaterials 179 2020-01-29
2018 E. Johanna L. Stéen, Vladimir Shalgunov, Christoph Denk, Hannes Mikula, Andreas Kjaer, Jesper L. Kristensen, Matthias M. Herth
Convenient Entry to 18 F-Labeled Amines through the Staudinger Reduction
published pages: , ISSN: 1434-193X, DOI: 10.1002/ejoc.201801457
European Journal of Organic Chemistry 2020-01-29
2018 Dennis Svatunek, Christoph Denk, Hannes Mikula
A computational model to predict the Diels–Alder reactivity of aryl/alkyl-substituted tetrazines
published pages: 833-837, ISSN: 0026-9247, DOI: 10.1007/s00706-017-2110-x
Monatshefte für Chemie - Chemical Monthly 149/4 2020-01-29

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The information about "CLICK-IT" are provided by the European Opendata Portal: CORDIS opendata.

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