Opendata, web and dolomites

FunctionalProteomics SIGNED

Proteomic fingerprinting of functionally characterized single synapses

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 FunctionalProteomics project word cloud

Explore the words cloud of the FunctionalProteomics project. It provides you a very rough idea of what is the project "FunctionalProteomics" about.

neuronal    composition    fixed    pyramidal    behaving    nerve    dramatic    clamp    proteins    pc    billions    tomography    regions    reveal    revealed    downregulation    molecularly    characterization    cells    hippocampal    imaging    cell    cognitive    remarkable    determined    quantitative    functionally    history    differences    postsynaptic    vivo    relationships    postembedding    partly    content    performed    photon    ca2    quantal    shape    connectome    connectivity    molecular    followed    synapses    mechanisms    circuit    ca1    correlations    animals    multiple    render    fingerprints    types    individual    excitable    created    single    investigations    genetic    hypothesis    size    array    brain    presynaptic    biophysical    performing    recordings    underlie    networks    century    vitro    our    astonishing    mglur1    patch    uniform    half    synaptic    alpha    demonstrated    diversity    immunolocalization    causal    consequence    head    dynamic    lm    quantify    morphologically    heterogeneity    functional   

Project "FunctionalProteomics" data sheet

The following table provides information about the project.

Coordinator
INSTITUTE OF EXPERIMENTAL MEDICINE - HUNGARIAN ACADEMY OF SCIENCES 

Organization address
address: Szigony utca 43
city: Budapest
postcode: 1083
website: www.koki.hu

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Hungary [HU]
 Total cost 2˙498˙750 €
 EC max contribution 2˙498˙750 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-ADG
 Funding Scheme ERC-ADG
 Starting year 2018
 Duration (year-month-day) from 2018-10-01   to  2023-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUTE OF EXPERIMENTAL MEDICINE - HUNGARIAN ACADEMY OF SCIENCES HU (Budapest) coordinator 2˙498˙750.00

Map

 Project objective

Our astonishing cognitive abilities are the consequence of complex connectivity within our neuronal networks and the large functional diversity of excitable nerve cells and their synapses. Investigations over the past half a century revealed dramatic diversity in shape, size and functional properties among synapses established by distinct cell types in different brain regions and demonstrated that the functional differences are partly due to different molecular mechanisms. However, synaptic diversity is also observed among synapses established by molecularly and morphologically uniform presynaptic cells on molecularly and morphologically uniform postsynaptic cells. Our hypothesis is that quantitative molecular differences underlie the functional diversity of such synapses. We will focus on hippocampal CA1 pyramidal cell (PC) to mGluR1α O-LM cell synapses, which show remarkable functional and molecular heterogeneity. In vitro multiple cell patch-clamp recordings followed by quantal analysis will be performed to quantify well-defined biophysical properties of these synapses. The molecular composition of the functionally characterized single synapses will be determined following the development of a novel postembedding immunolocalization method. Correlations between the molecular content and functional properties will be established and genetic up- and downregulation of individual synaptic proteins will be conducted to reveal causal relationships. Finally, correlations of the activity history and the functional properties of the synapses will be established by performing in vivo two-photon Ca2 imaging in head-fixed behaving animals followed by in vitro functional characterization of their synapses. Our results will reveal quantitative molecular fingerprints of functional properties, allowing us to render dynamic behaviour to billions of synapses when the connectome of the hippocampal circuit is created using array tomography.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "FUNCTIONALPROTEOMICS" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "FUNCTIONALPROTEOMICS" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

DISINTEGRATION (2019)

The Mass Politics of Disintegration

Read More  

PROGRESS (2019)

The Enemy of the Good: Towards a Theory of Moral Progress

Read More  

HyperBio (2019)

Vis-NIR Hyperspectral imaging for biomaterial quality control

Read More