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PathEVome SIGNED

Do Pathogen Extracellular Vesicles Deliver Crop Disease?

Total Cost €

0

EC-Contrib. €

0

Partnership

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 PathEVome project word cloud

Explore the words cloud of the PathEVome project. It provides you a very rough idea of what is the project "PathEVome" about.

proteins    cytoplasmic    effector    resolve    fusion    workpackage    throughput    causing    oomycetes    pathogens    routes    wp1    cell    question    vesicles    revealed    transport    wp    cells    pathogen    genome    pathevome    dimensional    wp3    food    transgenic    disease    final    plant    vital    destination    effectors    translocated    immunity    delivered    endocytic    threaten    debated    laboratory    biology    infection    diseases    suppress    filamentous    significantly    automated    microscopy    proteomics    evs    breakthrough    extracellular    critical    global    traffic    establishes    formed    crop    determined    broadly    biogenesis    biological    innovative    components    vesicular    endocytosis    corresponding    molecular    electron    living    brings    interface    security    ground    proteome    secretory    secreted    them    scientific    wp2    tools    discovery    arsenal    reside    route    fungi    inside    implicating    hotly    host    breaking    editing    ev    devastating    answered    pathology    accumulate    organisation    packaged    virulence    roles   

Project "PathEVome" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF DUNDEE 

Organization address
address: Nethergate
city: DUNDEE
postcode: DD1 4HN
website: www.dundee.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 2˙468˙260 €
 EC max contribution 2˙468˙260 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-ADG
 Funding Scheme ERC-ADG
 Starting year 2018
 Duration (year-month-day) from 2018-10-01   to  2023-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF DUNDEE UK (DUNDEE) coordinator 2˙130˙541.00
2    THE JAMES HUTTON INSTITUTE UK (DUNDEE) participant 337˙719.00

Map

 Project objective

Filamentous plant pathogens (fungi and oomycetes) cause the most devastating crop diseases and thus significantly threaten global food security. Essential components of their virulence arsenal are proteins called cytoplasmic effectors that are delivered inside plant cells to suppress immunity. One of the major scientific challenges in this field is understanding how effectors are secreted and translocated into host cells; a question that is hotly debated. An exciting breakthrough in my laboratory revealed that cytoplasmic effectors accumulate in extracellular vesicles (EVs), implicating this as a delivery route. This critical discovery establishes a vital need to address: • What proteins reside in EVs and how do EVs traffic them between pathogen and host cells? • How are EVs formed and how are effectors packaged into them? • What are the routes for uptake of cytoplasmic effectors into host cells and how do they reach their destination?

Each question will be answered by a corresponding workpackage (WP) that brings challenging, innovative approaches to the study of molecular plant pathology. In WP1 proteomics and transgenic approaches will allow the EV proteome to be determined and high-throughput automated electron microscopy will resolve the 3-dimensional organisation of the interface between plant and pathogen. In WP2, new molecular cell biological approaches and genome editing will facilitate an understanding of effector secretory routes and EV biogenesis. In WP3, fusion or endocytosis of EVs with plant cells will be studied and the endocytic routes to delivery of effectors to their final destination will be defined. PathEVome will develop a ground-breaking understanding of effector delivery from filamentous pathogens to the inside of living plant cells. It will provide tools and approaches beyond the current state-of-the-art in infection cell biology that can be broadly adopted to study the roles of vesicular transport in causing disease.

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The information about "PATHEVOME" are provided by the European Opendata Portal: CORDIS opendata.

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