Explore the words cloud of the REPLICHROMA project. It provides you a very rough idea of what is the project "REPLICHROMA" about.
The following table provides information about the project.
TECHNISCHE UNIVERSITEIT DELFT
|Coordinator Country||Netherlands [NL]|
|Total cost||2˙388˙100 €|
|EC max contribution||2˙388˙100 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2018-09-01 to 2023-08-31|
Take a look of project's partnership.
|1||TECHNISCHE UNIVERSITEIT DELFT||NL (DELFT)||coordinator||2˙388˙100.00|
DNA replication is essential to cellular function. During a lifetime, each of us synthesizes a light-year’s length of DNA, but this process is so robust that few of us will develop cancer. In eukaryotes, DNA is packed into chromatin, a hierarchical DNA-protein assembly of which the nucleosome forms the basic unit. Chromatin replication convolves DNA replication with the duplication and reassembly of all DNA-associated proteins. Understanding the coupling between these processes has fundamental implications for epigenetic inheritance and cancer. The goal of this proposal is to gain spatiotemporal insight into chromatin replication by using our biophysical expertise in replication and chromosomal dynamics to build up a mechanistic timeline of the process. We will harness recent advances in the reconstitution of the yeast replisome alongside our novel, high-throughput single-molecule approach to visualize and quantify the collaboration between a single yeast replisome and the histone chaperones to achieve chromatin replication. We will: •Monitor the assembly of the replisome on chromatin and visualize how nucleosomes impact its progression. •Quantify how the replisome and histone chaperones disrupt nucleosomes and retain histones for further processing. •Detect the deposition of newly synthesized histones behind the replisome and reveal the interactions between replisome components and histone chaperones that couple replication to nucleosome assembly. •Report on the phenomenon of epigenetic inheritance by imaging histone recycling between parental and daughter DNA. We will examine its timing and efficiency, the conformations of reassembled nucleosomes, and any preferential recycling to either daughter DNA. This proposal places us in a unique position to make major contributions to the field of chromatin replication, and to provide the field with a powerful tool to investigate topics from fundamental questions in molecular biology to the performance of new cancer drugs.
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "REPLICHROMA" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (email@example.com) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "REPLICHROMA" are provided by the European Opendata Portal: CORDIS opendata.
Quantum Coherent Control: Self–Interference of Electron Beams with NanostructuresRead More
Fast, Flexible, and Convenient: a simple insert system for the in situ NMR analysis of very fast reactions on a modern open-access FT NMR spectrometerRead More
A new platform technology for the on-demand access to large acenesRead More