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DISCOVER SIGNED

Death receptor signalling in tumour immune editing

Total Cost €

0

EC-Contrib. €

0

Partnership

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Project "DISCOVER" data sheet

The following table provides information about the project.

Coordinator
NATIONAL UNIVERSITY OF IRELAND GALWAY 

Organization address
address: UNIVERSITY ROAD
city: Galway
postcode: H91
website: www.nuigalway.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Total cost 904˙500 €
 EC max contribution 904˙500 € (100%)
 Programme 1. H2020-EU.1.3.3. (Stimulating innovation by means of cross-fertilisation of knowledge)
 Code Call H2020-MSCA-RISE-2017
 Funding Scheme MSCA-RISE
 Starting year 2018
 Duration (year-month-day) from 2018-01-01   to  2021-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    NATIONAL UNIVERSITY OF IRELAND GALWAY IE (Galway) coordinator 121˙500.00
2    CELL STRESS DISCOVERIES LIMITED IE (GALWAY) participant 207˙000.00
3    ENIOS APPLICATIONS IDIOTIKI KEFALAIOUCHIKI ETAIREIA EL (KALLITHEA) participant 189˙000.00
4    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) participant 148˙500.00
5    DOKUZ EYLUL UNIVERSITESI TR (ALSANCAK IZMIR) participant 103˙500.00
6    APOFAS BIOTECH FR (RENNES) participant 67˙500.00
7    UNIVERSITAET BERN CH (BERN) participant 67˙500.00
8    IZMIR BIYOTIP VE GENOM MERKEZI TR (IZMIR) participant 0.00

Map

 Project objective

During tumour development there is a bi-directional communication between cancer cells and immune cells; the process termed tumour immune editing. The impact is reciprocal, shaping both the visibility and susceptibility of the tumour to immune eradication as well as the ability of the immune effector cells to recognise and launch an immune response against tumour cells. Death ligand-death receptor signalling is a key mechanism to kill tumour cells during the early stages of tumour development (tumour immune surveillance). However, the role of this signalling pathway in evolved tumours is poorly understood. Recent pioneering results from DISCOVER consortium members highlighted non-canonical signal tranduction pathways mediated by death receptors, which regulates both tumour cell behaviour (motility, invasion) and effector immune cell function in the tumour microenvironment. The aim of the DISCOVER proposal is to bring a collaborative research network together to determine the role of death ligand-death receptor signalling in tumour - immune cell interactions. The DISCOVER programme will determine how non-canonical signal transduction pathways driven by death receptors control effector immnue cell functions and tumour cell behaviour. The outputs of the research will be used to develop informed therapeutic strategies to interfere with non-canonical death receptor signalling in order to re-activate anti-tumour immune attack and sensitise tumour cells to this attack. The DISCOVER proposal will integrate the research activity of seven beneficiary organisations from 5 European countries, including 3 companies and create a framework for knowledge and reagent exchange for early stage and experienced researchers. The consortium will bring together scientists from immunology and cancer cell biology and combines these with expertise in systems biology, drug discovery and pre-clinical drug development thus forging a consortium where scientific discoveries drive innovation.

 Deliverables

List of deliverables.
DISCOVER Facebook &Twitter accounts Websites, patent fillings, videos etc. 2020-02-11 14:31:56
DISCOVER website Websites, patent fillings, videos etc. 2020-02-11 14:31:56

Take a look to the deliverables list in detail:  detailed list of DISCOVER deliverables.

 Publications

year authors and title journal last update
List of publications.
2019 Ludmila Cardoso Alves Michael D Berger Thodoris Koutsandreas Nick Kirschke Christoph Lauer Roman Spörri Aristotelis Chatziioannou Nadia Corazza Philippe Krebs
Non‐apoptotic TRAIL function modulates NK cell activity during viral infection
published pages: pages 1-17, ISSN: 1469-221X, DOI: 10.15252/embr.201948789
EMBO reports e48789 2020-02-11
2019 Agathe Dubuisson, Cécile Favreau, Eric Fourmaux, Sabrina Lareure, Rafael Rodrigues-Saraiva, Catherine Pellat-Deceunynck, Said El Alaoui, Olivier Micheau
Generation and characterization of novel anti-DR4 and anti-DR5 antibodies developed by genetic immunization
published pages: , ISSN: 2041-4889, DOI: 10.1038/s41419-019-1343-5
Cell Death & Disease 10/2 2020-02-11
2018 Olivier Micheau
Regulation of TNF-Related Apoptosis-Inducing Ligand Signaling by Glycosylation
published pages: 715, ISSN: 1422-0067, DOI: 10.3390/ijms19030715
International Journal of Molecular Sciences 19/3 2020-02-11

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The information about "DISCOVER" are provided by the European Opendata Portal: CORDIS opendata.

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