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DISCOVER SIGNED

Death receptor signalling in tumour immune editing

Total Cost €

EC-Contrib. €

Partnership

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DISCOVER project word cloud

Explore the words cloud of the DISCOVER project. It provides you a very rough idea of what is the project "DISCOVER" about.

tranduction integrate anti strategies mechanism countries drive shaping framework cell effector network regulates outputs motility immune scientific members re function ligand expertise immnue companies interactions stages discovery biology collaborative create combines cells bi interfere mediated launch therapeutic stage receptors tumour editing signal pioneering during microenvironment seven exchange cancer drug informed susceptibility surveillance sensitise functions discoveries signalling reciprocal directional tumours reagent eradication invasion receptor canonical forging termed innovation activate kill attack communication transduction scientists discover highlighted clinical recognise immunology visibility poorly death beneficiary

Project "DISCOVER" data sheet

The following table provides information about the project.

Coordinator	NATIONAL UNIVERSITY OF IRELAND GALWAY Organization address address: UNIVERSITY ROAD city: Galway postcode: H91 website: www.nuigalway.ie contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Ireland [IE]
Total cost	904˙500 €
EC max contribution	904˙500 € (100%)
Programme	1. H2020-EU.1.3.3. (Stimulating innovation by means of cross-fertilisation of knowledge)
Code Call	H2020-MSCA-RISE-2017
Funding Scheme	MSCA-RISE
Starting year	2018
Duration (year-month-day)	from 2018-01-01 to 2021-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	NATIONAL UNIVERSITY OF IRELAND GALWAY NATIONAL UNIVERSITY OF IRELAND GALWAY Organization address address: UNIVERSITY ROAD city: Galway postcode: H91 website: www.nuigalway.ie contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IE (Galway)	coordinator	121˙500.00
2	CELL STRESS DISCOVERIES LIMITED CELL STRESS DISCOVERIES LIMITED Organization address address: UNIT 204, NUIG BUSINESS INNOVATION CENTRE, NEWCASTLE ROAD city: GALWAY postcode: n.a. website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IE (GALWAY)	participant	207˙000.00
3	ENIOS APPLICATIONS IDIOTIKI KEFALAIOUCHIKI ETAIREIA ENIOS APPLICATIONS IDIOTIKI KEFALAIOUCHIKI ETAIREIA Organization address address: AL. PANTOU 25 city: KALLITHEA postcode: 17671 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	EL (KALLITHEA)	participant	189˙000.00
4	INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Organization address address: RUE DE TOLBIAC 101 city: PARIS postcode: 75654 website: www.inserm.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	148˙500.00
5	DOKUZ EYLUL UNIVERSITESI DOKUZ EYLUL UNIVERSITESI Organization address address: CUMHURIYET BULVARI 144 city: ALSANCAK IZMIR postcode: 35210 website: http://www.deu.edu.tr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	TR (ALSANCAK IZMIR)	participant	103˙500.00
6	APOFAS BIOTECH APOFAS BIOTECH Organization address address: 2 RUE DU PROFESSEUR LEON BERNARD CAMPUS DE VILLEJE BAT 8 BIOSIT city: RENNES postcode: 35043 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (RENNES)	participant	67˙500.00
7	UNIVERSITAET BERN UNIVERSITAET BERN Organization address address: HOCHSCHULSTRASSE 6 city: BERN postcode: 3012 website: http://www.unibe.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (BERN)	participant	67˙500.00
8	IZMIR BIYOTIP VE GENOM MERKEZI IZMIR BIYOTIP VE GENOM MERKEZI Organization address address: MITHATPASA CAD. NO:58/5 BALCOVA city: IZMIR postcode: 35340 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	TR (IZMIR)	participant	0.00

Map

Project objective

During tumour development there is a bi-directional communication between cancer cells and immune cells; the process termed tumour immune editing. The impact is reciprocal, shaping both the visibility and susceptibility of the tumour to immune eradication as well as the ability of the immune effector cells to recognise and launch an immune response against tumour cells. Death ligand-death receptor signalling is a key mechanism to kill tumour cells during the early stages of tumour development (tumour immune surveillance). However, the role of this signalling pathway in evolved tumours is poorly understood. Recent pioneering results from DISCOVER consortium members highlighted non-canonical signal tranduction pathways mediated by death receptors, which regulates both tumour cell behaviour (motility, invasion) and effector immune cell function in the tumour microenvironment. The aim of the DISCOVER proposal is to bring a collaborative research network together to determine the role of death ligand-death receptor signalling in tumour - immune cell interactions. The DISCOVER programme will determine how non-canonical signal transduction pathways driven by death receptors control effector immnue cell functions and tumour cell behaviour. The outputs of the research will be used to develop informed therapeutic strategies to interfere with non-canonical death receptor signalling in order to re-activate anti-tumour immune attack and sensitise tumour cells to this attack. The DISCOVER proposal will integrate the research activity of seven beneficiary organisations from 5 European countries, including 3 companies and create a framework for knowledge and reagent exchange for early stage and experienced researchers. The consortium will bring together scientists from immunology and cancer cell biology and combines these with expertise in systems biology, drug discovery and pre-clinical drug development thus forging a consortium where scientific discoveries drive innovation.

Deliverables

List of deliverables.
DISCOVER Facebook &Twitter accounts	Websites, patent fillings, videos etc.	2020-02-11 14:31:56
DISCOVER website	Websites, patent fillings, videos etc.	2020-02-11 14:31:56

Take a look to the deliverables list in detail: detailed list of DISCOVER deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2019	Ludmila Cardoso Alves Michael D Berger Thodoris Koutsandreas Nick Kirschke Christoph Lauer Roman SpÃ¶rri Aristotelis Chatziioannou Nadia Corazza Philippe Krebs Nonâ€apoptotic TRAIL function modulates NK cell activity during viral infection published pages: pages 1-17, ISSN: 1469-221X, DOI: 10.15252/embr.201948789	EMBO reports e48789	2020-02-11
2019	Agathe Dubuisson, CÃ©cile Favreau, Eric Fourmaux, Sabrina Lareure, Rafael Rodrigues-Saraiva, Catherine Pellat-Deceunynck, Said El Alaoui, Olivier Micheau Generation and characterization of novel anti-DR4 and anti-DR5 antibodies developed by genetic immunization published pages: , ISSN: 2041-4889, DOI: 10.1038/s41419-019-1343-5	Cell Death & Disease 10/2	2020-02-11
2018	Olivier Micheau Regulation of TNF-Related Apoptosis-Inducing Ligand Signaling by Glycosylation published pages: 715, ISSN: 1422-0067, DOI: 10.3390/ijms19030715	International Journal of Molecular Sciences 19/3	2020-02-11

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The information about "DISCOVER" are provided by the European Opendata Portal: CORDIS opendata.

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