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SMR SIGNED

Stroke Management through RGTA®: SMR

Total Cost €

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EC-Contrib. €

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Partnership

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Project "SMR" data sheet

The following table provides information about the project.

Coordinator
ORGANES TISSUS REGENERATION REPARATION REMPLACEMENT 

Organization address
address: RUE FRANCAISE 4
city: PARIS
postcode: 75001
website: www.otr3.com

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 3˙404˙200 €
 EC max contribution 2˙382˙940 € (70%)
 Programme 1. H2020-EU.3. (PRIORITY 'Societal challenges)
2. H2020-EU.2.3. (INDUSTRIAL LEADERSHIP - Innovation In SMEs)
3. H2020-EU.2.1. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies)
 Code Call H2020-SMEInst-2018-2020-2
 Funding Scheme SME-2
 Starting year 2018
 Duration (year-month-day) from 2018-10-01   to  2022-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ORGANES TISSUS REGENERATION REPARATION REMPLACEMENT FR (PARIS) coordinator 2˙382˙940.00

Map

 Project objective

Stroke is the 2nd cause of death and major handicaps in industrialized countries. At present, the only available treatment for ischemic stroke are thrombolysis and thrombectomy. However, very few patients are eligible, and it is therefore absolutely urgent to find an alternative. RGTA® are synthetic polysaccharides, mimicking endogenous macro-molecules called heparan sulphates, that make up the biological networks in which our cells live and reproduce: the extracellular matrix. We have recently investigated the neuroprotective potential of a novel specific RGTA® (OTR41H-1) at the preclinical level using a rodent model of transient focal cerebral ischemia The i.v. administration of OTR41H-1 elicited a reduction of 39,6% of the volume of infarction at 48 hours following the insult. Interestingly, this RGTA®-induced reduction of brain damage persisted up to the chronic stage and RGTA®-treated animals showed a significant improvement of functional recovery (motor and sensorial) when compared to control animals. Translational stroke studies in rodent models have thus already demonstrated the beneficial effects of RGTA® in acute phase and the project is now ready for next stages of its route to market introduction, including clinical validation and product registration. The objective of the SMR project is to translate experimental findings into medical innovation, leading to a quick benefit for stroke patients. Positive outcomes of the project will lead rapidly to a EU medical device registration of OTR41H-1 injectable solution and its market introduction in Europe for the stroke indication.

 Publications

year authors and title journal last update
List of publications.
2018 Yacine Khelif, Jérôme Toutain, Marie-Sophie Quittet, Sandrine Chantepie, Xavier Laffray, Samuel Valable, Didier Divoux, Fernando Sineriz, Emanuelle Pascolo-Rebouillat, Dulce Papy-Garcia, Denis Barritault, Omar Touzani, Myriam Bernaudin
A heparan sulfate-based matrix therapy reduces brain damage and enhances functional recovery following stroke
published pages: 5814-5827, ISSN: 1838-7640, DOI: 10.7150/thno.28252
Theranostics 8/21 2020-03-05

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The information about "SMR" are provided by the European Opendata Portal: CORDIS opendata.

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