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SRIMEM SIGNED

Super-Resolution Imaging and Mapping of Epigenetic Modifications

Total Cost €

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EC-Contrib. €

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Partnership

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Project "SRIMEM" data sheet

The following table provides information about the project.

Coordinator
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV 

Organization address
address: HOFGARTENSTRASSE 8
city: MUENCHEN
postcode: 80539
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 171˙460 €
 EC max contribution 171˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-09-01   to  2020-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) coordinator 171˙460.00

Map

 Project objective

Epigenetic marks are posttranslational modifications of chromatin that act as gene regulators. Although every cell-type contains the same DNA sequence, the epigenetic marks dictate specific function of each cell-type. Epigenetic modifications are both heritable and dynamic, and can be treated enzymatically to reverse. The dynamic marks sometimes lead to aberrant gene regulation in cells, causing diseases such as cancer, Alzheimer’s, and diabetes. Therefore, epigenetic state of individual genes can be used to identify the aberrant genes to reverse them.

In this project, a novel assay for simultaneous identification of epigenetic marks and their genomic position is proposed. State-of-the-art DNA-PAINT super-resolution microscopy, developed by Prof. Jungmann, in combination with immunofluorescence in situ hybridization (iFISH) will be used to identify the epigenetic marks in human cells with very high precision (<5 nm). The novelty of this assay is that, for the first time, it will allow to read the epigenetic marks, their genomic and 3D position in the nucleus simultaneously, for precise mapping of the epigenetic state of genes in individual cells. The assay can be used as a tool to identify aberrant marks in cells for diagnosing diseases caused by these modifications. Therefore, it has a high potential for both research in biotechnology and diagnostics.

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The information about "SRIMEM" are provided by the European Opendata Portal: CORDIS opendata.

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