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Set-to-change SIGNED

Set to change: early life factors restricting and promoting neurocognitive plasticity through life

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 Set-to-change project word cloud

Explore the words cloud of the Set-to-change project. It provides you a very rough idea of what is the project "Set-to-change" about.

disentangle    total    longitudinally    environmental    variation    crossover    functioned    lies    individuals    bw    points    degrees    certain    spread    huge    adult    tested    nature    virtual    ba    neurodevelopmentally    mono    progress    twins    functional    months    prenatal    brain    constitution    predicted    function    discordance    genetic    origins    lifespan    memory    variability    younger    varying    training    mri    time    locomotion    mz    ecologically    demands    remarkable    differences    cognitive    unknown    mediators    ab    utilizing    correlated    dizygotic    breaking    substantial    variance    health    indexed    navigation    birth    prospective    individual    shows    adulthood    young    cognition    400    ways    me    employ    weight    novelty    setting    acknowledged    intrinsically    lifestyle    neurocognitive    valid    true    regulate    age    ground    older    makeup    synthesis    intervention    epigenetic    interact    post    hypothesize    multiple    neurodevelopmental    influences    environment    plasticity    experimental    life   

Project "Set-to-change" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITETET I OSLO 

Organization address
address: PROBLEMVEIEN 5-7
city: OSLO
postcode: 313
website: www.uio.no

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Norway [NO]
 Total cost 1˙999˙996 €
 EC max contribution 1˙999˙996 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-COG
 Funding Scheme ERC-COG
 Starting year 2018
 Duration (year-month-day) from 2018-10-01   to  2023-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITETET I OSLO NO (OSLO) coordinator 1˙999˙996.00

Map

 Project objective

Cognitive function in old age can be predicted from how you functioned when you were young. This is remarkable, as there are substantial cognitive age changes. Are we neurodevelopmentally set to change through life in certain ways? The objective of Set-to-change is to test whether and how early life environmental factors and genetic makeup interact to regulate neurocognitive plasticity through the lifespan. Neurocognitive plasticity; i.e. changes in brain and cognition in response to environmental demands over time, shows huge individual variability, for unknown reasons. Neurodevelopmental origins of functional variation through the lifespan are acknowledged, but the pathways need to be identified. As individual constitution and environment are intrinsically correlated, to make progress beyond state of the art, this can only be tested in an experimental setting.

The novelty and ground-breaking nature of the project lies in the synthesis of a targeted experimental approach testing differences in neurocognitive plasticity by training of younger and older adult mono- (MZ) and dizygotic twins (total n = 400 individuals), with varying degrees of prenatal environmental variance, as indexed by their extent of discordance in birth weight (BW). BW discordance in MZ twins enables me to disentangle early environmental and genetic influences on neurocognitive plasticity. I will employ a novel ecologically valid memory intervention utilizing navigation with true locomotion and prospective memory in virtual reality. Twins will be assessed with brain MRI, cognitive, health and epigenetic measures at multiple time points spread across 2.5 years pre- and post- 3 months intervention in a AB/BA crossover design, to investigate neurocognitive plasticity and age change longitudinally, as well as possible lifestyle and epigenetic mediators. I hypothesize that early life environmental influences will interact with genetic makeup in determining neurocognitive plasticity in adulthood.

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The information about "SET-TO-CHANGE" are provided by the European Opendata Portal: CORDIS opendata.

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