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REACT SIGNED

REsponsive theranostic nanosystems for Advanced Cancer Treatment

Total Cost €

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EC-Contrib. €

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Partnership

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 REACT project word cloud

Explore the words cloud of the REACT project. It provides you a very rough idea of what is the project "REACT" about.

deadly    despite    hardly    inorganic    therapy    environmental    milieu    proportional    drugs    vitro    modified    tool    diagnostic    cues    mathematical    nanomedicines    dramatically    environment    disease    tumors    molecules    consist    biological    porous    tumor    vivo    survival    stimuli    drug    reduce    doses    human    proteins    cancer    sense    nanomedicine    benefits    carriers    changing    matrix    diagnosis    nanoparticles    anti    adapt    biology    surface    effort    clinically    potentially    efficacy    react    pathophysiological    agents    exquisite    locally    unparalleled    patients    metabolites    tools    gels    genes    expert    glioblastoma    prognostic    therapies    engineered    nanosystems    selectivity    risk    ultrasensitive    implicated    employed    pi    organic    utilize    cargo    implanted    local    chemotherapeutics    sustained    injectable    release    urgent    intends    hybrid    screening    improvement    carrier    triggered    exists    candidates    translated    treatment    efforts    neuroblastoma    chemotherapeutic    responsive   

Project "REACT" data sheet

The following table provides information about the project.

Coordinator
THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN 

Organization address
address: College Green
city: DUBLIN
postcode: 2
website: www.tcd.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Total cost 1˙498˙345 €
 EC max contribution 1˙498˙345 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN IE (DUBLIN) coordinator 1˙498˙345.00

Map

 Project objective

REACT aims to dramatically impact the targeted release of diagnostic agents and drugs with nanomedicines that respond to biological cues or changing pathophysiological conditions, thus enabling ultrasensitive diagnosis and exquisite therapy selectivity. Nanomedicine research against cancer focuses on the local targeted delivery of chemotherapeutics to enhance drug efficacy and reduce side effects. Despite all the efforts in the design of chemotherapeutic agents as nanomedicines, hardly any improvement has been translated into benefits for patients’ survival. There is an urgent need for improved carrier systems able to deliver high doses of diagnostic agents and anti-cancer drugs to the tumor. Stimuli responsive carriers are promising candidates since the release of the cargo can be triggered locally in the tumor environment. Currently, there exists an unparalleled effort to identify genes, proteins and metabolites implicated in human disease and utilize systems biology and mathematical approaches in order to develop new prognostic tools for the treatment of cancer and develop more targeted therapies for patients. As an expert in drug delivery systems, the PI intends to bring all these efforts and advances into the design of stimuli responsive organic-inorganic hybrid nanoparticles that can adapt their response to the biological milieu. The novel engineered delivery systems will consist of an inorganic porous matrix surface-modified with tumor-specific molecules with the ability to sense changes in the environmental conditions and react by providing a proportional release. These nanosystems can potentially be employed for early in vitro diagnosis through effective screening of deadly tumors, such as neuroblastoma and glioblastoma. Moreover, through the sustained delivery of the nanosystems from injectable gels that can be locally implanted in patients at risk of developing a tumor, a clinically relevant tool for in vivo diagnosis and targeted therapy can be achieved.

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The information about "REACT" are provided by the European Opendata Portal: CORDIS opendata.

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