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REACT SIGNED

REsponsive theranostic nanosystems for Advanced Cancer Treatment

Total Cost €

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EC-Contrib. €

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Partnership

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 REACT project word cloud

Explore the words cloud of the REACT project. It provides you a very rough idea of what is the project "REACT" about.

implicated    human    inorganic    urgent    deadly    local    clinically    unparalleled    molecules    engineered    injectable    consist    carrier    modified    release    tumors    despite    hybrid    utilize    patients    improvement    neuroblastoma    environment    vitro    intends    doses    nanomedicine    glioblastoma    anti    ultrasensitive    screening    potentially    biological    tools    tumor    environmental    reduce    prognostic    metabolites    sustained    survival    benefits    disease    agents    nanosystems    efforts    locally    pi    candidates    therapies    proportional    efficacy    surface    react    chemotherapeutic    vivo    triggered    drugs    porous    biology    mathematical    cues    genes    cargo    effort    responsive    diagnostic    changing    employed    translated    implanted    therapy    matrix    stimuli    drug    treatment    carriers    nanoparticles    diagnosis    adapt    tool    organic    cancer    sense    milieu    hardly    chemotherapeutics    nanomedicines    gels    proteins    pathophysiological    exists    selectivity    expert    risk    exquisite    dramatically   

Project "REACT" data sheet

The following table provides information about the project.

Coordinator
THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN 

Organization address
address: College Green
city: DUBLIN
postcode: 2
website: www.tcd.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Total cost 1˙498˙345 €
 EC max contribution 1˙498˙345 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN IE (DUBLIN) coordinator 1˙498˙345.00

Map

 Project objective

REACT aims to dramatically impact the targeted release of diagnostic agents and drugs with nanomedicines that respond to biological cues or changing pathophysiological conditions, thus enabling ultrasensitive diagnosis and exquisite therapy selectivity. Nanomedicine research against cancer focuses on the local targeted delivery of chemotherapeutics to enhance drug efficacy and reduce side effects. Despite all the efforts in the design of chemotherapeutic agents as nanomedicines, hardly any improvement has been translated into benefits for patients’ survival. There is an urgent need for improved carrier systems able to deliver high doses of diagnostic agents and anti-cancer drugs to the tumor. Stimuli responsive carriers are promising candidates since the release of the cargo can be triggered locally in the tumor environment. Currently, there exists an unparalleled effort to identify genes, proteins and metabolites implicated in human disease and utilize systems biology and mathematical approaches in order to develop new prognostic tools for the treatment of cancer and develop more targeted therapies for patients. As an expert in drug delivery systems, the PI intends to bring all these efforts and advances into the design of stimuli responsive organic-inorganic hybrid nanoparticles that can adapt their response to the biological milieu. The novel engineered delivery systems will consist of an inorganic porous matrix surface-modified with tumor-specific molecules with the ability to sense changes in the environmental conditions and react by providing a proportional release. These nanosystems can potentially be employed for early in vitro diagnosis through effective screening of deadly tumors, such as neuroblastoma and glioblastoma. Moreover, through the sustained delivery of the nanosystems from injectable gels that can be locally implanted in patients at risk of developing a tumor, a clinically relevant tool for in vivo diagnosis and targeted therapy can be achieved.

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The information about "REACT" are provided by the European Opendata Portal: CORDIS opendata.

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