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ActinSensor SIGNED

Identification and characterization of a novel damage sensor for cytoskeletal proteins in Drosophila

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 ActinSensor project word cloud

Explore the words cloud of the ActinSensor project. It provides you a very rough idea of what is the project "ActinSensor" about.

stat    dcs    elicits    sensing    candidate    noxious    immunobiology    mediated    atp    melanogaster    sterile    rnai    insights    secondary    signalling    modulate    independently    serve    extracellular    mammals    discovered    release    mediating    sudden    evolution    genetic    gain    contributor    fruit    screens    function    sensors    vertebrates    organisms    infection    return    endogenous    receptor    anticipate    homeostasis    damp    dead    actin    molecules    jak    lectin    drosophila    sensor    vivo    silico    vitro    conduct    dngr    functional    fly    tissues    thought    acid    patterns    signals    recruit    presentation    functionally    myocardial    screen    innate    antigen    inflammatory    cross    death    biochemical    dendritic    host    damps    cells    dependent    transduction    cd8    list    immune    conserved    infarction    validate    recognised    give    implicated    expressed    diversity    serves    dngr1    multiple    cytoskeletal    injury    homolog    damaged    stimuli    obscure    transplantation    cell    laboratory    stroke    inflammation    molecular    evolutionary    uric    tissue    damage    candidates    counteract    elicit   

Project "ActinSensor" data sheet

The following table provides information about the project.

Coordinator
THE FRANCIS CRICK INSTITUTE LIMITED 

Organization address
address: 1 MIDLAND ROAD
city: LONDON
postcode: NW1 1AT
website: www.crick.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2020-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE FRANCIS CRICK INSTITUTE LIMITED UK (LONDON) coordinator 195˙454.00

Map

 Project objective

Inflammation is a host response that evolved to counteract noxious stimuli that result from infection or tissue injury, and serves to return the affected tissue to homeostasis. Cell death-associated sterile inflammation is a major contributor to secondary tissue damage associated with multiple conditions such as myocardial infarction, transplantation, and stroke. Damaged tissues are thought to elicit their inflammatory effects through the sudden release from cells of endogenous Damage-Associated Molecular patterns (DAMPs) that serve to recruit and modulate the function of immune cells. In vertebrates, a diversity of molecules have been implicated as DAMPs, including ATP, uric acid, and F-actin. In mammals, F-actin is recognised as a DAMP by the C-type lectin receptor DNGR1, expressed on CD8 Dendritic cells (DCs), that signals to favour the cross-presentation of dead-cell antigen to CD8 T-cells. Independently of its work on DNGR-1, the host laboratory discovered that extracellular actin elicits a JAK-STAT-dependent inflammatory response in the fruit fly (Drosophila melanogaster). DNGR-1 does not have a functional homolog in fly, therefore the actin sensor remains obscure. In order to identify the molecular sensor of extracellular actin we have conducted an in silico-based screen to identify a candidate list of potential sensors. To functionally evaluate these candidates, we will conduct in vivo RNAi and in vitro gain-of-function screens in Drosophila. We will validate the role for this novel sensor in mediating sensing of extracellular actin through multiple genetic and biochemical approaches. We expect our proposal to give novel insights into the signalling transduction and immunobiology of host responses to evolutionary conserved DAMPs. We anticipate that by understanding cytoskeletal-mediated innate inflammatory responses in fly, it will provide important insights into the evolution of similar damage sensor response pathways in higher organisms

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The information about "ACTINSENSOR" are provided by the European Opendata Portal: CORDIS opendata.

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