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ActinSensor SIGNED

Identification and characterization of a novel damage sensor for cytoskeletal proteins in Drosophila

Total Cost €


EC-Contrib. €






 ActinSensor project word cloud

Explore the words cloud of the ActinSensor project. It provides you a very rough idea of what is the project "ActinSensor" about.

recruit    candidate    vertebrates    acid    stroke    organisms    innate    mediated    conserved    mediating    dngr1    elicits    sensors    sudden    conduct    receptor    antigen    contributor    homolog    transduction    silico    dendritic    candidates    discovered    cytoskeletal    implicated    validate    extracellular    dead    dcs    damaged    tissues    transplantation    sensing    genetic    drosophila    immune    thought    secondary    actin    vivo    infection    sterile    recognised    counteract    gain    sensor    multiple    noxious    rnai    list    damp    vitro    stimuli    release    damps    biochemical    atp    give    laboratory    signalling    molecules    inflammation    presentation    cell    evolution    modulate    independently    uric    infarction    fly    dependent    cells    functionally    endogenous    patterns    serves    function    molecular    anticipate    functional    immunobiology    stat    dngr    mammals    return    melanogaster    death    elicit    evolutionary    tissue    host    myocardial    lectin    screen    screens    jak    homeostasis    insights    damage    serve    cd8    inflammatory    injury    signals    diversity    obscure    fruit    cross    expressed   

Project "ActinSensor" data sheet

The following table provides information about the project.


Organization address
address: 1 MIDLAND ROAD
city: LONDON
postcode: NW1 1AT

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2020-12-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Inflammation is a host response that evolved to counteract noxious stimuli that result from infection or tissue injury, and serves to return the affected tissue to homeostasis. Cell death-associated sterile inflammation is a major contributor to secondary tissue damage associated with multiple conditions such as myocardial infarction, transplantation, and stroke. Damaged tissues are thought to elicit their inflammatory effects through the sudden release from cells of endogenous Damage-Associated Molecular patterns (DAMPs) that serve to recruit and modulate the function of immune cells. In vertebrates, a diversity of molecules have been implicated as DAMPs, including ATP, uric acid, and F-actin. In mammals, F-actin is recognised as a DAMP by the C-type lectin receptor DNGR1, expressed on CD8 Dendritic cells (DCs), that signals to favour the cross-presentation of dead-cell antigen to CD8 T-cells. Independently of its work on DNGR-1, the host laboratory discovered that extracellular actin elicits a JAK-STAT-dependent inflammatory response in the fruit fly (Drosophila melanogaster). DNGR-1 does not have a functional homolog in fly, therefore the actin sensor remains obscure. In order to identify the molecular sensor of extracellular actin we have conducted an in silico-based screen to identify a candidate list of potential sensors. To functionally evaluate these candidates, we will conduct in vivo RNAi and in vitro gain-of-function screens in Drosophila. We will validate the role for this novel sensor in mediating sensing of extracellular actin through multiple genetic and biochemical approaches. We expect our proposal to give novel insights into the signalling transduction and immunobiology of host responses to evolutionary conserved DAMPs. We anticipate that by understanding cytoskeletal-mediated innate inflammatory responses in fly, it will provide important insights into the evolution of similar damage sensor response pathways in higher organisms

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The information about "ACTINSENSOR" are provided by the European Opendata Portal: CORDIS opendata.

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