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INTEGRATA SIGNED

Integrating chemical and biological approaches to target NAD production and signaling in cancer

Total Cost €

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EC-Contrib. €

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Partnership

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INTEGRATA project word cloud

Explore the words cloud of the INTEGRATA project. It provides you a very rough idea of what is the project "INTEGRATA" about.

biosynthesis signaling autocrine proof pro therapeutics of promotion public pharmacology nicotinic dna differentiation shared phd naprt space nampt smes vivo events phosphoribosyltransferase oncogenic haematological motility centres proven carcinogenesis solid training producing broad participation cancer dinucleotide courses upregulated newly interdisciplinary cells extracellular applicability expertise moonlight acid downstream encompasses roles cancers fuel exchange appear academic nicotinamide utilizing transferrable enzymes joint skills toxicity paracrine deregulated train escape geared scientific exerting adenine pharma models inhibitors overarching active nucleotide cell nad agents metabolic preclinical 14 de networking biosynthetic students demands education biotech immune underlies intense intersectoral integrata plan infrastructures repair

Project "INTEGRATA" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITA DEGLI STUDI DI GENOVA Organization address address: VIA BALBI 5 city: GENOVA postcode: 16126 website: www.unige.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Italy [IT]
Total cost	3˙738˙573 €
EC max contribution	3˙738˙573 € (100%)
Programme	1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
Code Call	H2020-MSCA-ITN-2018
Funding Scheme	MSCA-ITN-ETN
Starting year	2018
Duration (year-month-day)	from 2018-11-01 to 2022-10-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITA DEGLI STUDI DI GENOVA UNIVERSITA DEGLI STUDI DI GENOVA Organization address address: VIA BALBI 5 city: GENOVA postcode: 16126 website: www.unige.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (GENOVA)	coordinator	522˙999.00
2	THE UNIVERSITY OF SHEFFIELD THE UNIVERSITY OF SHEFFIELD Organization address address: FIRTH COURT WESTERN BANK city: SHEFFIELD postcode: S10 2TN website: www.shef.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (SHEFFIELD)	participant	303˙172.00
3	CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS Organization address address: RUE DU BUGNON 21 city: LAUSANNE postcode: 1011 website: www.chuv.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (LAUSANNE)	participant	281˙276.00
4	NOVIMMUNE SA NOVIMMUNE SA Organization address address: CHEMIN DES AULX 14 city: PLAN LES OUATES GENEVE postcode: 1228 website: www.novimmune.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (PLAN LES OUATES GENEVE)	participant	281˙276.00
5	UNIVERSITE DE GENEVE UNIVERSITE DE GENEVE Organization address address: RUE DU GENERAL DUFOUR 24 city: GENEVE postcode: 1211 website: www.unige.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (GENEVE)	participant	281˙276.00
6	UNIVERSITE DE MONTPELLIER UNIVERSITE DE MONTPELLIER Organization address address: 163 RUE AUGUSTE BROUSSONNET city: MONTPELLIER postcode: 34090 website: www.umontpellier.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (MONTPELLIER)	participant	274˙802.00
7	INNOVAMOL CONSULTING SRL INNOVAMOL CONSULTING SRL Organization address address: VIALE ALFEO CORASSORI 24 city: MODENA postcode: 41124 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (MODENA)	participant	261˙499.00
8	UNIVERSITA DEGLI STUDI DI TORINO UNIVERSITA DEGLI STUDI DI TORINO Organization address address: VIA GIUSEPPE VERDI 8 city: TORINO postcode: 10124 website: www.unito.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (TORINO)	participant	261˙499.00
9	UNIVERSITA DEGLI STUDI DI TRENTO UNIVERSITA DEGLI STUDI DI TRENTO Organization address address: VIA CALEPINA 14 city: TRENTO postcode: 38122 website: www.unitn.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (TRENTO)	participant	261˙499.00
10	HEIDELBERG PHARMA RESEARCH GMBH HEIDELBERG PHARMA RESEARCH GMBH Organization address address: SCHRIESHEIMER STRASSE 101 city: LADENBURG postcode: 68526 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (LADENBURG)	participant	252˙788.00
11	UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF Organization address address: Martinistrasse 52 city: HAMBURG postcode: 20251 website: www.uke.uni-hamburg.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (HAMBURG)	participant	252˙788.00
12	UNIVERSITATSKLINIKUM BONN UNIVERSITATSKLINIKUM BONN Organization address address: VENUSBERG-CAMPUS 1 city: BONN postcode: 53127 website: www.ukb.uni-bonn.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (BONN)	participant	252˙788.00
13	UNIVERSIDAD DE SEVILLA UNIVERSIDAD DE SEVILLA Organization address address: CALLE S. FERNANDO 4 city: SEVILLA postcode: 41004 website: www.us.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (SEVILLA)	participant	250˙904.00
14	INNOVATION ACTA S.R.L. INNOVATION ACTA S.R.L. Organization address address: VIA D.A. AZUNI, 9 city: ROMA postcode: 196 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (ROMA)	partner	0.00
15	UNIVERSITE DE LAUSANNE UNIVERSITE DE LAUSANNE Organization address address: Quartier Unil-Centre Bâtiment Unicentre city: LAUSANNE postcode: 1015 website: www.unil.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (LAUSANNE)	partner	0.00

Map

Project objective

Deregulated nicotinamide adenine dinucleotide (NAD) biosynthesis and signaling underlies many aspects of carcinogenesis. NAD biosynthetic enzymes, such as nicotinamide phosphoribosyltransferase (NAMPT) and nicotinic acid phosphoribosyltransferase (NAPRT), are commonly upregulated in cancer cells, where they fuel increased metabolic demands and downstream enzymes involved in DNA repair and in the promotion of cell growth, cell motility, de-differentiation and immune escape. In addition, NAD-producing enzymes, such as NAMPT, moonlight in the extracellular space, exerting strongly pro-oncogenic, autocrine and paracrine effects. Many of these roles of NAD-producing and NAD-utilizing enzymes appear to be shared between solid and haematological cancers. Thus, agents targeting NAD production or signaling are expected to have broad applicability. INTEGRATA will: 1. develop new NAD biosynthesis and NAD/nucleotide signaling inhibitors; 2. assess pharmacology and toxicity of the new therapeutics in preclinical models; 3. achieve the proof-of-concept of activity of the newly generated agents in relevant in vivo cancer models. INTEGRATA will train 14 PhD students in an overarching, interdisciplinary training programme that will include training-by-research, joint courses of technical, scientific, and transferrable skills, active participation to public scientific events, and an intense intersectoral networking exchange plan. The INTEGRATA Consortium encompasses academic institutions, research centres, and SMEs/biotech pharma, all with proven experience in higher education and training, and geared with state-of-the-art scientific and technical expertise and infrastructures.

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