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INTEGRATA SIGNED

Integrating chemical and biological approaches to target NAD production and signaling in cancer

Total Cost €

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EC-Contrib. €

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Partnership

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 INTEGRATA project word cloud

Explore the words cloud of the INTEGRATA project. It provides you a very rough idea of what is the project "INTEGRATA" about.

smes    newly    phd    phosphoribosyltransferase    cell    broad    exerting    acid    scientific    networking    pharma    training    of    deregulated    roles    nicotinic    nucleotide    intense    producing    shared    joint    pro    infrastructures    utilizing    events    autocrine    oncogenic    expertise    biosynthetic    demands    appear    fuel    promotion    nampt    proven    interdisciplinary    participation    naprt    escape    solid    moonlight    motility    nicotinamide    extracellular    geared    plan    applicability    dna    space    pharmacology    skills    academic    metabolic    inhibitors    encompasses    toxicity    carcinogenesis    public    transferrable    signaling    biosynthesis    education    proof    courses    active    14    adenine    biotech    underlies    preclinical    repair    agents    overarching    haematological    train    downstream    centres    cells    cancer    exchange    intersectoral    cancers    enzymes    de    therapeutics    nad    dinucleotide    paracrine    students    vivo    upregulated    differentiation    models    integrata    immune   

Project "INTEGRATA" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITA DEGLI STUDI DI GENOVA 

Organization address
address: VIA BALBI 5
city: GENOVA
postcode: 16126
website: www.unige.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 3˙738˙573 €
 EC max contribution 3˙738˙573 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2018
 Funding Scheme MSCA-ITN-ETN
 Starting year 2018
 Duration (year-month-day) from 2018-11-01   to  2022-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITA DEGLI STUDI DI GENOVA IT (GENOVA) coordinator 522˙999.00
2    THE UNIVERSITY OF SHEFFIELD UK (SHEFFIELD) participant 303˙172.00
3    CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS CH (LAUSANNE) participant 281˙276.00
4    NOVIMMUNE SA CH (PLAN LES OUATES GENEVE) participant 281˙276.00
5    UNIVERSITE DE GENEVE CH (GENEVE) participant 281˙276.00
6    UNIVERSITE DE MONTPELLIER FR (MONTPELLIER) participant 274˙802.00
7    INNOVAMOL CONSULTING SRL IT (MODENA) participant 261˙499.00
8    UNIVERSITA DEGLI STUDI DI TORINO IT (TORINO) participant 261˙499.00
9    UNIVERSITA DEGLI STUDI DI TRENTO IT (TRENTO) participant 261˙499.00
10    HEIDELBERG PHARMA RESEARCH GMBH DE (LADENBURG) participant 252˙788.00
11    UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF DE (HAMBURG) participant 252˙788.00
12    UNIVERSITATSKLINIKUM BONN DE (BONN) participant 252˙788.00
13    UNIVERSIDAD DE SEVILLA ES (SEVILLA) participant 250˙904.00
14    INNOVATION ACTA S.R.L. IT (ROMA) partner 0.00
15    UNIVERSITE DE LAUSANNE CH (LAUSANNE) partner 0.00

Map

 Project objective

Deregulated nicotinamide adenine dinucleotide (NAD) biosynthesis and signaling underlies many aspects of carcinogenesis. NAD biosynthetic enzymes, such as nicotinamide phosphoribosyltransferase (NAMPT) and nicotinic acid phosphoribosyltransferase (NAPRT), are commonly upregulated in cancer cells, where they fuel increased metabolic demands and downstream enzymes involved in DNA repair and in the promotion of cell growth, cell motility, de-differentiation and immune escape. In addition, NAD-producing enzymes, such as NAMPT, moonlight in the extracellular space, exerting strongly pro-oncogenic, autocrine and paracrine effects. Many of these roles of NAD-producing and NAD-utilizing enzymes appear to be shared between solid and haematological cancers. Thus, agents targeting NAD production or signaling are expected to have broad applicability. INTEGRATA will: 1. develop new NAD biosynthesis and NAD/nucleotide signaling inhibitors; 2. assess pharmacology and toxicity of the new therapeutics in preclinical models; 3. achieve the proof-of-concept of activity of the newly generated agents in relevant in vivo cancer models. INTEGRATA will train 14 PhD students in an overarching, interdisciplinary training programme that will include training-by-research, joint courses of technical, scientific, and transferrable skills, active participation to public scientific events, and an intense intersectoral networking exchange plan. The INTEGRATA Consortium encompasses academic institutions, research centres, and SMEs/biotech pharma, all with proven experience in higher education and training, and geared with state-of-the-art scientific and technical expertise and infrastructures.

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The information about "INTEGRATA" are provided by the European Opendata Portal: CORDIS opendata.

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