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INTEGRATA SIGNED

Integrating chemical and biological approaches to target NAD production and signaling in cancer

Total Cost €

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EC-Contrib. €

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Partnership

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 INTEGRATA project word cloud

Explore the words cloud of the INTEGRATA project. It provides you a very rough idea of what is the project "INTEGRATA" about.

pharmacology    appear    cell    exerting    roles    underlies    courses    agents    utilizing    centres    nicotinamide    promotion    acid    expertise    enzymes    education    carcinogenesis    cancer    skills    biosynthetic    dna    students    adenine    extracellular    escape    transferrable    intense    14    joint    de    shared    public    academic    haematological    networking    biotech    events    dinucleotide    differentiation    encompasses    proof    nampt    immune    participation    toxicity    training    newly    of    pro    nad    nicotinic    pharma    therapeutics    naprt    vivo    oncogenic    inhibitors    proven    producing    train    interdisciplinary    applicability    phosphoribosyltransferase    exchange    biosynthesis    nucleotide    overarching    space    demands    scientific    moonlight    metabolic    motility    active    cells    plan    smes    upregulated    fuel    deregulated    models    paracrine    autocrine    preclinical    phd    intersectoral    repair    downstream    signaling    integrata    geared    broad    infrastructures    cancers    solid   

Project "INTEGRATA" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITA DEGLI STUDI DI GENOVA 

Organization address
address: VIA BALBI 5
city: GENOVA
postcode: 16126
website: www.unige.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 3˙738˙573 €
 EC max contribution 3˙738˙573 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2018
 Funding Scheme MSCA-ITN-ETN
 Starting year 2018
 Duration (year-month-day) from 2018-11-01   to  2022-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITA DEGLI STUDI DI GENOVA IT (GENOVA) coordinator 522˙999.00
2    THE UNIVERSITY OF SHEFFIELD UK (SHEFFIELD) participant 303˙172.00
3    CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS CH (LAUSANNE) participant 281˙276.00
4    NOVIMMUNE SA CH (PLAN LES OUATES GENEVE) participant 281˙276.00
5    UNIVERSITE DE GENEVE CH (GENEVE) participant 281˙276.00
6    UNIVERSITE DE MONTPELLIER FR (MONTPELLIER) participant 274˙802.00
7    INNOVAMOL CONSULTING SRL IT (MODENA) participant 261˙499.00
8    UNIVERSITA DEGLI STUDI DI TORINO IT (TORINO) participant 261˙499.00
9    UNIVERSITA DEGLI STUDI DI TRENTO IT (TRENTO) participant 261˙499.00
10    HEIDELBERG PHARMA RESEARCH GMBH DE (LADENBURG) participant 252˙788.00
11    UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF DE (HAMBURG) participant 252˙788.00
12    UNIVERSITATSKLINIKUM BONN DE (BONN) participant 252˙788.00
13    UNIVERSIDAD DE SEVILLA ES (SEVILLA) participant 250˙904.00
14    INNOVATION ACTA S.R.L. IT (ROMA) partner 0.00
15    UNIVERSITE DE LAUSANNE CH (LAUSANNE) partner 0.00

Map

 Project objective

Deregulated nicotinamide adenine dinucleotide (NAD) biosynthesis and signaling underlies many aspects of carcinogenesis. NAD biosynthetic enzymes, such as nicotinamide phosphoribosyltransferase (NAMPT) and nicotinic acid phosphoribosyltransferase (NAPRT), are commonly upregulated in cancer cells, where they fuel increased metabolic demands and downstream enzymes involved in DNA repair and in the promotion of cell growth, cell motility, de-differentiation and immune escape. In addition, NAD-producing enzymes, such as NAMPT, moonlight in the extracellular space, exerting strongly pro-oncogenic, autocrine and paracrine effects. Many of these roles of NAD-producing and NAD-utilizing enzymes appear to be shared between solid and haematological cancers. Thus, agents targeting NAD production or signaling are expected to have broad applicability. INTEGRATA will: 1. develop new NAD biosynthesis and NAD/nucleotide signaling inhibitors; 2. assess pharmacology and toxicity of the new therapeutics in preclinical models; 3. achieve the proof-of-concept of activity of the newly generated agents in relevant in vivo cancer models. INTEGRATA will train 14 PhD students in an overarching, interdisciplinary training programme that will include training-by-research, joint courses of technical, scientific, and transferrable skills, active participation to public scientific events, and an intense intersectoral networking exchange plan. The INTEGRATA Consortium encompasses academic institutions, research centres, and SMEs/biotech pharma, all with proven experience in higher education and training, and geared with state-of-the-art scientific and technical expertise and infrastructures.

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The information about "INTEGRATA" are provided by the European Opendata Portal: CORDIS opendata.

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