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IVSTED TERMINATED

In vivo super-resolution imaging of synapses in the hippocampus

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 IVSTED project word cloud

Explore the words cloud of the IVSTED project. It provides you a very rough idea of what is the project "IVSTED" about.

me    limiting    significantly    mice    adaptive    microscopy    center    light    optics    behavior    expertise    behavioral    animals    realistic    underlying    surgery    opportunity    dynamics    density    size    super    diseases    view    synaptic    extremely    spine    capacity    resolution    neurodegenerative    weeks    longitudinal    hypothesized    vast    structures    hippocampal    animal    spines    optical    shedding    memory    sections    push    cellular    regulation    hippocampus    physiology    mechanisms    course    vivo    nanometric    neuroimaging    properly    dendritic    provides    dynamic    morphology    paradigm    things    builds    incomplete    correlating    leveraging    brain    framework    turnover    mammalian    imaging    deeply    performance    neuroscience    fixed    conventional    integrating    live    correlate    perform    electron    region    plasticity    structural    archetypical    neurons    correlates    function    living    places    inputs    postsynaptic    analyze    trace    fails    resolve    impairment    snapshots    remember    basis    biophysics    frontier    experimental    mouse    anatomical   

Project "IVSTED" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 185˙076 €
 EC max contribution 185˙076 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-05-01   to  2021-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 185˙076.00

Map

 Project objective

The hippocampus is a deeply embedded region in the mammalian brain that has long been considered the archetypical center for memory formation. Hippocampal neurons process information by integrating a vast number of synaptic inputs via dendritic spines. These postsynaptic structures are highly dynamic and their plasticity is hypothesized to be important structural correlate of the memory trace. However, due to their nanometric size and high density, it is extremely challenging to study the function and regulation of dendritic spines under realistic experimental conditions. Indeed, conventional light microscopy fails to properly resolve them while electron microscopy only provides snapshots from fixed brain sections. Therefore, our view of spine dynamics remains very incomplete, limiting our understanding of the synaptic mechanisms underlying brain physiology and animal behavior. Leveraging recent advances in optical microscopy, adaptive optics and mouse brain surgery, this project seeks to establish a new paradigm based on correlating super-resolution imaging of dendritic spines in living mice with behavioral analyses of the capacity of mice to learn and remember things. To this end, I will (1) establish super-resolution imaging of spines in the deeply embedded hippocampus, (2) perform longitudinal imaging to determine spine morphology and turnover over the course of weeks in live animals and (3) investigate how spine plasticity correlates with memory performance in the same animal. This project builds on my expertise in biophysics and advanced microscopy and will offer me a unique opportunity to contribute to a dynamic research field at one of the top places for neuroscience in Europe. Going significantly beyond the state-of-the-art, this project will push the frontier in neuroimaging, shedding new light on the anatomical basis of memory formation and providing a framework to analyze in vivo the cellular mechanisms of memory impairment in neurodegenerative diseases.

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The information about "IVSTED" are provided by the European Opendata Portal: CORDIS opendata.

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