Opendata, web and dolomites


In vivo super-resolution imaging of synapses in the hippocampus

Total Cost €


EC-Contrib. €






 IVSTED project word cloud

Explore the words cloud of the IVSTED project. It provides you a very rough idea of what is the project "IVSTED" about.

perform    leveraging    provides    correlates    remember    live    memory    neuroscience    imaging    me    resolution    dynamics    physiology    spine    snapshots    electron    neuroimaging    mechanisms    cellular    opportunity    turnover    adaptive    behavioral    basis    fails    structural    brain    things    properly    hippocampus    neurons    shedding    diseases    regulation    archetypical    inputs    course    push    density    hypothesized    plasticity    weeks    animals    fixed    optics    framework    center    conventional    paradigm    extremely    nanometric    correlate    sections    incomplete    surgery    spines    super    structures    synaptic    impairment    dynamic    biophysics    size    resolve    experimental    mammalian    places    capacity    performance    deeply    light    builds    postsynaptic    expertise    realistic    longitudinal    underlying    behavior    region    morphology    integrating    living    neurodegenerative    microscopy    trace    anatomical    frontier    dendritic    correlating    optical    function    hippocampal    vast    vivo    view    animal    analyze    significantly    limiting    mouse    mice   

Project "IVSTED" data sheet

The following table provides information about the project.


Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 185˙076 €
 EC max contribution 185˙076 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-05-01   to  2021-04-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

The hippocampus is a deeply embedded region in the mammalian brain that has long been considered the archetypical center for memory formation. Hippocampal neurons process information by integrating a vast number of synaptic inputs via dendritic spines. These postsynaptic structures are highly dynamic and their plasticity is hypothesized to be important structural correlate of the memory trace. However, due to their nanometric size and high density, it is extremely challenging to study the function and regulation of dendritic spines under realistic experimental conditions. Indeed, conventional light microscopy fails to properly resolve them while electron microscopy only provides snapshots from fixed brain sections. Therefore, our view of spine dynamics remains very incomplete, limiting our understanding of the synaptic mechanisms underlying brain physiology and animal behavior. Leveraging recent advances in optical microscopy, adaptive optics and mouse brain surgery, this project seeks to establish a new paradigm based on correlating super-resolution imaging of dendritic spines in living mice with behavioral analyses of the capacity of mice to learn and remember things. To this end, I will (1) establish super-resolution imaging of spines in the deeply embedded hippocampus, (2) perform longitudinal imaging to determine spine morphology and turnover over the course of weeks in live animals and (3) investigate how spine plasticity correlates with memory performance in the same animal. This project builds on my expertise in biophysics and advanced microscopy and will offer me a unique opportunity to contribute to a dynamic research field at one of the top places for neuroscience in Europe. Going significantly beyond the state-of-the-art, this project will push the frontier in neuroimaging, shedding new light on the anatomical basis of memory formation and providing a framework to analyze in vivo the cellular mechanisms of memory impairment in neurodegenerative diseases.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "IVSTED" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email ( and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "IVSTED" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

MathematicsAnalogies (2019)

Mathematics Analogies

Read More  

NaWaTL (2020)

Narrative, Writing, and the Teotihuacan Language: Exploring Language History Through Phylogenetics, Epigraphy and Iconography

Read More  

RegARcis (2020)

Role of the SWI/SNF complex in the Androgen Receptor cistrome regulation

Read More