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IVSTED TERMINATED

In vivo super-resolution imaging of synapses in the hippocampus

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 IVSTED project word cloud

Explore the words cloud of the IVSTED project. It provides you a very rough idea of what is the project "IVSTED" about.

basis    neuroimaging    things    properly    adaptive    structures    light    archetypical    significantly    realistic    paradigm    inputs    structural    experimental    trace    nanometric    turnover    vivo    mice    spine    mouse    region    brain    morphology    spines    electron    opportunity    cellular    remember    vast    imaging    optical    biophysics    correlating    behavioral    hippocampal    synaptic    weeks    correlate    correlates    hypothesized    size    live    conventional    animal    analyze    incomplete    plasticity    neuroscience    mechanisms    resolution    surgery    view    shedding    longitudinal    anatomical    impairment    animals    diseases    density    expertise    dynamics    fixed    memory    snapshots    optics    me    integrating    fails    course    leveraging    living    regulation    deeply    performance    physiology    resolve    sections    super    provides    perform    frontier    push    underlying    builds    mammalian    limiting    function    capacity    places    framework    center    dendritic    hippocampus    behavior    dynamic    neurodegenerative    neurons    extremely    microscopy    postsynaptic   

Project "IVSTED" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 185˙076 €
 EC max contribution 185˙076 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-05-01   to  2021-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 185˙076.00

Map

 Project objective

The hippocampus is a deeply embedded region in the mammalian brain that has long been considered the archetypical center for memory formation. Hippocampal neurons process information by integrating a vast number of synaptic inputs via dendritic spines. These postsynaptic structures are highly dynamic and their plasticity is hypothesized to be important structural correlate of the memory trace. However, due to their nanometric size and high density, it is extremely challenging to study the function and regulation of dendritic spines under realistic experimental conditions. Indeed, conventional light microscopy fails to properly resolve them while electron microscopy only provides snapshots from fixed brain sections. Therefore, our view of spine dynamics remains very incomplete, limiting our understanding of the synaptic mechanisms underlying brain physiology and animal behavior. Leveraging recent advances in optical microscopy, adaptive optics and mouse brain surgery, this project seeks to establish a new paradigm based on correlating super-resolution imaging of dendritic spines in living mice with behavioral analyses of the capacity of mice to learn and remember things. To this end, I will (1) establish super-resolution imaging of spines in the deeply embedded hippocampus, (2) perform longitudinal imaging to determine spine morphology and turnover over the course of weeks in live animals and (3) investigate how spine plasticity correlates with memory performance in the same animal. This project builds on my expertise in biophysics and advanced microscopy and will offer me a unique opportunity to contribute to a dynamic research field at one of the top places for neuroscience in Europe. Going significantly beyond the state-of-the-art, this project will push the frontier in neuroimaging, shedding new light on the anatomical basis of memory formation and providing a framework to analyze in vivo the cellular mechanisms of memory impairment in neurodegenerative diseases.

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The information about "IVSTED" are provided by the European Opendata Portal: CORDIS opendata.

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