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IVSTED TERMINATED

In vivo super-resolution imaging of synapses in the hippocampus

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 IVSTED project word cloud

Explore the words cloud of the IVSTED project. It provides you a very rough idea of what is the project "IVSTED" about.

morphology    sections    view    super    mice    conventional    inputs    electron    shedding    turnover    spine    impairment    function    underlying    dynamics    paradigm    brain    mammalian    archetypical    dendritic    places    realistic    living    course    analyze    biophysics    hippocampus    animals    resolve    resolution    perform    physiology    imaging    frontier    region    cellular    memory    live    plasticity    expertise    integrating    basis    adaptive    fixed    deeply    me    dynamic    postsynaptic    weeks    size    neuroscience    properly    trace    opportunity    structures    synaptic    hypothesized    neurodegenerative    surgery    hippocampal    neuroimaging    snapshots    behavioral    neurons    structural    animal    things    incomplete    microscopy    correlate    mechanisms    performance    significantly    fails    correlates    experimental    push    anatomical    extremely    leveraging    optics    density    mouse    limiting    builds    behavior    optical    vast    framework    vivo    remember    longitudinal    center    regulation    diseases    provides    nanometric    light    correlating    capacity    spines   

Project "IVSTED" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 185˙076 €
 EC max contribution 185˙076 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-05-01   to  2021-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 185˙076.00

Map

 Project objective

The hippocampus is a deeply embedded region in the mammalian brain that has long been considered the archetypical center for memory formation. Hippocampal neurons process information by integrating a vast number of synaptic inputs via dendritic spines. These postsynaptic structures are highly dynamic and their plasticity is hypothesized to be important structural correlate of the memory trace. However, due to their nanometric size and high density, it is extremely challenging to study the function and regulation of dendritic spines under realistic experimental conditions. Indeed, conventional light microscopy fails to properly resolve them while electron microscopy only provides snapshots from fixed brain sections. Therefore, our view of spine dynamics remains very incomplete, limiting our understanding of the synaptic mechanisms underlying brain physiology and animal behavior. Leveraging recent advances in optical microscopy, adaptive optics and mouse brain surgery, this project seeks to establish a new paradigm based on correlating super-resolution imaging of dendritic spines in living mice with behavioral analyses of the capacity of mice to learn and remember things. To this end, I will (1) establish super-resolution imaging of spines in the deeply embedded hippocampus, (2) perform longitudinal imaging to determine spine morphology and turnover over the course of weeks in live animals and (3) investigate how spine plasticity correlates with memory performance in the same animal. This project builds on my expertise in biophysics and advanced microscopy and will offer me a unique opportunity to contribute to a dynamic research field at one of the top places for neuroscience in Europe. Going significantly beyond the state-of-the-art, this project will push the frontier in neuroimaging, shedding new light on the anatomical basis of memory formation and providing a framework to analyze in vivo the cellular mechanisms of memory impairment in neurodegenerative diseases.

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The information about "IVSTED" are provided by the European Opendata Portal: CORDIS opendata.

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